Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Christel Kroigaard"'
Autor:
Ole Frøbert, Ulf Simonsen, Vladimir V. Matchkov, Susie Mogensen, Berit Dalsgaard Nielsen, Attila Kun, Elise R. Hedegaard, Alun D. Hughes, Christel Kroigaard
Publikováno v:
British Journal of Pharmacology. 171:69-82
Background and Purpose Hypoxia causes vasodilatation of coronary arteries, but the underlying mechanisms are poorly understood. We hypothesized that hypoxia reduces intracellular Ca2+ concentration ([Ca2+]i) by opening of K channels and release of H2
Autor:
Søren-Peter Olesen, Thomas Dalsgaard, Christel Kroigaard, Olga Kudryavtseva, Christine Wandall-Frostholm, Ulf Simonsen
Publikováno v:
Experimental Physiology. 98:957-969
Calcium-activated potassium channels of small (K(Ca)2, SK) and intermediate (K(Ca)3.1, IK) conductance are involved in endothelium-dependent relaxation of pulmonary arteries. We hypothesized that the function and expression of K(Ca)2 and K(Ca)3.1 inc
Autor:
Gorm Nielsen, Hans K. Pilegaard, Thomas Dalsgaard, Britt Elmedal Laursen, Ulf Simonsen, Ralf Köhler, Christel Kroigaard
Publikováno v:
British Journal of Pharmacology. 167:37-47
BACKGROUND AND PURPOSE Small (KCa2) and intermediate (KCa3.1) conductance calcium-activated potassium channels (KCa) may contribute to both epithelium- and endothelium-dependent relaxations, but this has not been established in human pulmonary arteri
Publikováno v:
British Journal of Pharmacology. 160:1496-1508
Background and purpose: Small (SKCa or KCa2) and intermediate (IKCa or KCa3.1) conductance calcium-activated potassium channels are involved in regulation of vascular tone and blood pressure. The present study investigated whether NS309 (6,7-dichloro
Publikováno v:
Krøigaard, C, Dalsgaard, T & Simonsen, U 2010, ' Mechanisms underlying epithelium-dependent relaxation in rat bronchioles: analogy to EDHF-type relaxation in rat pulmonary arteries ', American Journal of Physiology: Lung Cellular and Molecular Physiology, vol. 298, no. 4, pp. L531-42 . https://doi.org/10.1152/ajplung.00220.2009
This study investigated the mechanisms underlying epithelium-derived hyperpolarizing factor (EpDHF)-type relaxation in rat bronchioles. Immunohistochemistry was performed, and rat bronchioles and pulmonary arteries were mounted in microvascular myogr
Autor:
Christel, Kroigaard, Olga, Kudryavtseva, Thomas, Dalsgaard, Christine, Wandall-Frostholm, Søren-Peter, Olesen, Ulf, Simonsen
Publikováno v:
Experimental physiology. 98(4)
Calcium-activated potassium channels of small (K(Ca)2, SK) and intermediate (K(Ca)3.1, IK) conductance are involved in endothelium-dependent relaxation of pulmonary arteries. We hypothesized that the function and expression of K(Ca)2 and K(Ca)3.1 inc
Autor:
Christel, Kroigaard, Thomas, Dalsgaard, Gorm, Nielsen, Britt E, Laursen, Hans, Pilegaard, Ralf, Köhler, Ulf, Simonsen
Publikováno v:
British journal of pharmacology. 167(1)
Small (K(Ca) 2) and intermediate (K(Ca) 3.1) conductance calcium-activated potassium channels (K(Ca) ) may contribute to both epithelium- and endothelium-dependent relaxations, but this has not been established in human pulmonary arteries and bronchi
Autor:
Gorm Nielsen, Ebbe Boedtkjer, Thomas Dalsgaard, Christel Kroigaard, Mikkel Misfeldt, Olav L. Schjørring, Lilliana Beck, Alun D. Hughes, Edgaras Stankevičius, Ulf Simonsen
Publikováno v:
Stankevicius, E, Dalsgaard, T, Kroigaard, C, Beck, L, Bødtkjer, E, Misfeldt, M W, Nielsen, G, Schjorring, O, Hughes, A & Simonsen, U 2011, ' Opening of Small and Intermediate Calcium-Activated Potassium Channels Induces Relaxation Mainly Mediated by Nitric-Oxide Release in Large Arteries and Endothelium-Derived Hyperpolarizing Factor in Small Arteries from Rat ', Journal of Pharmacology and Experimental Therapeutics, vol. 339, no. 3, pp. 842-850 . https://doi.org/10.1124/jpet.111.179242
Stankevicius, E, Dalsgaard, T, Krøigaard, C, Beck, L, Boedtkjer, E, Misfeldt, M W, Nielsen, G, Schjørring, O, Hughes, A & Simonsen, U 2011, ' Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat ', Journal of Pharmacology and Experimental Therapeutics, vol. 339, no. 3, pp. 842-850 .
Aarhus University
Stankevicius, E, Dalsgaard, T, Krøigaard, C, Beck, L, Boedtkjer, E, Misfeldt, M W, Nielsen, G, Schjørring, O, Hughes, A & Simonsen, U 2011, ' Opening of small and intermediate calcium-activated potassium channels induces relaxation mainly mediated by nitric-oxide release in large arteries and endothelium-derived hyperpolarizing factor in small arteries from rat ', Journal of Pharmacology and Experimental Therapeutics, vol. 339, no. 3, pp. 842-850 .
Aarhus University
This study was designed to investigate whether calcium-activated potassium channels of small (SK(Ca) or K(Ca)2) and intermediate (IK(Ca) or K(Ca) 3.1) conductance activated by 6,7-dichloro-1H-indole-2,3-dione 3-oxime (NS309) are involved in both nitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0213fae65de7683a21ebe608f16a61d3
https://portal.findresearcher.sdu.dk/da/publications/2b9d0794-5366-4f5f-9c04-ca5d8251e78e
https://portal.findresearcher.sdu.dk/da/publications/2b9d0794-5366-4f5f-9c04-ca5d8251e78e
Publikováno v:
Dalsgaard, T, Krøigaard, C & Simonsen, U 2010, ' Calcium-activated potassium channels-a therapeutic target for modulating nitric oxide in cardiovascular disease? ', Expert Opinion On Therapeutic Targets, vol. 14, no. 8, pp. 1-13 . https://doi.org/10.1517/14728222.2010.500616
Udgivelsesdato: 2010-Jun-19 Importance of the field: Cardiovascular risk factors are often associated with endothelial dysfunction, which is also prognostic for occurrence of cardiovascular events. Endothelial dysfunction is reflected by blunted vaso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a35eb3b25cb7ed38ab41f6ad3605e7
https://pure.au.dk/portal/da/publications/calciumactivated-potassium-channels--a-therapeutic-target-for-modulating-nitric-oxide-in-cardiovascular-disease(ab474390-843d-11df-8c1a-000ea68e967b).html
https://pure.au.dk/portal/da/publications/calciumactivated-potassium-channels--a-therapeutic-target-for-modulating-nitric-oxide-in-cardiovascular-disease(ab474390-843d-11df-8c1a-000ea68e967b).html
Publikováno v:
The FASEB Journal. 23
Purpose Endothelial dysfunction and impaired vasodilation may be involved in the pathogenesis of retinal vascular diseases. In the present study, the mechanisms underlying bradykinin vasodilation were examined and whether calcium-activated potassium