Výsledky vyhledávání - "Christel Drewke"

Akademický článek

The Key Role of Peltate Glandular Trichomes in Symbiota Comprising Clavicipitaceous Fungi of the Genus Periglandula and Their Host Plants

Autor: Ulrike Steiner, Sabine Hellwig, Mahalia A. Ahimsa-Müller, Nicola Grundmann, Shu-Ming Li, Christel Drewke, Eckhard Leistner

Publikováno v: Toxins, Vol 7, Iss 4, Pp 1355-1373 (2015)

Clavicipitaceous fungi producing ergot alkaloids were recently discovered to be epibiotically associated with peltate glandular trichomes of Ipomoea asarifolia and Turbina corymbosa, dicotyledonous plants of the family Convolvulaceae. Mediators of th

Externí odkaz: https://doaj.org/article/cbb5184dd4934208bc5e4368e5afd998

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The experimental power of FR900359 to study Gq-regulated biological processes

Publikováno v: Nature Communications

Despite the discovery of heterotrimeric αβγ G proteins ∼25 years ago, their selective perturbation by cell-permeable inhibitors remains a fundamental challenge. Here we report that the plant-derived depsipeptide FR900359 (FR) is ideally suited t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b26f05dca16b186dc13b71425c09af5
https://eprints.gla.ac.uk/115886/1/115886.pdf

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Applying label-free dynamic mass redistribution technology to frame signaling of G protein–coupled receptors noninvasively in living cells

Autor: Jesus Gomeza, Evi Kostenis, Johannes Schmidt, Ralf Schröder, Dorina Kaufel, Graeme Milligan, Nicole Janssen, Manuel Grundmann, Nicole Merten, Wiebke K. Seemann, Klaus Mohr, Stefanie Blättermann, Christel Drewke, Lucas Peters

Publikováno v: Nature Protocols. 6:1748-1760

Label-free dynamic mass redistribution (DMR) is a cutting-edge assay technology that enables real-time detection of integrated cellular responses in living cells. It relies on detection of refractive index alterations on biosensor-coated microplates

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f33df705eb45f4b85346c40ac779e3b
https://doi.org/10.1038/nprot.2011.386

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Ginkgo biloba and Ginkgotoxin

Autor: Eckhard Leistner, Christel Drewke

Publikováno v: Journal of Natural Products. 73:86-92

Products prepared from Ginkgo biloba are top-selling phytopharmaceuticals especially in Europe and major botanical dietary supplements in the United States. In European medicine, G. biloba medications are used to improve memory, to treat neuronal dis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::771401c1f2c91aba0c607a077f5c3406
https://doi.org/10.1021/np9005019

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The C-terminal Tail of CRTH2 Is a Key Molecular Determinant That Constrains Gαi and Downstream Signaling Cascade Activation

Autor: Nicole Merten, Jesper Mosolff Mathiesen, Friederike Krop, Andree Blaukat, Christel Drewke, Lene Martini, Anamarija Kruljac-Letunic, Ralf Schröder, Jennifer L. Whistler, Leonardo Pardo, Trond Ulven, Elizabeth Tran, Jesus Gomeza, Evi Kostenis, Ye Fang

Publikováno v: Schroeder, R, Merten, N, Mathiesen, J M, Martini, L, Letunic, A K, Krop, F, Blaukat, A, Fang, Y, Tran, E, Ulven, T, Drewke, C, Whistler, J, Pardo, L, Gomeza, J & Kostenis, E 2009, ' The C-terminal tail of CRTH2 is a key molecular determinant that constrains GalphaI-and downstream-signaling cascade activation ', Journal of Biological Chemistry, vol. 284, no. 2, pp. 1324-1336 . https://doi.org/10.1074/jbc.M806867200

Prostaglandin D(2) activation of the seven-transmembrane receptor CRTH2 regulates numerous cell functions that are important in inflammatory diseases, such as asthma. Despite its disease implication, no studies to date aimed at identifying receptor d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a348a20c4df6c040f9cd7ddb85d759
https://doi.org/10.1074/jbc.m806867200

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Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes

Autor: Andreas Spinrath, Christian Urban, Andrew D. Bond, Elisabeth Christiansen, Evi Kostenis, Matthias U. Kassack, Nicole Merten, Alexandra Hamacher, Trond Ulven, Christel Drewke, Susanne Ullrich, Kasper K. Karlsen, Kathrin Liebscher

Publikováno v: Christiansen, E, Urban, C, Merten, N, Liebscher, K, Karlsen, K, Hamacher, A, Spinrath, A, Bond, A, Drewke, C, Ullrich, S, Kassack, M, Kostenis, E & Ulven, T 2008, ' Discovery of Potent and Selective Agonists for the Free Fatty Acid Receptor 1 (FFA1/GPR40), a Potential Target for the Treatment of Type II Diabetes ', Journal of Medicinal Chemistry, vol. 51, no. 22, pp. 7061-7064 . https://doi.org/10.1021/jm8010178

Udgivelsesdato: 2008-Oct-24 A series of 4-phenethynyldihydrocinnamic acid agonists of the free fatty acid receptor 1 (FFA 1) has been discovered and explored. The preferred compound 20 (TUG-424, EC 50 = 32 nM) significantly increased glucose-stimulat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a32d41d73bd05040f7c78cb0d77936e
https://doi.org/10.1021/jm8010178

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Biosynthesis and Accumulation of Ergoline Alkaloids in a Mutualistic Association between Ipomoea asarifolia (Convolvulaceae) and a Clavicipitalean Fungus

Autor: Christel Drewke, Anne Markert, Nicola Steffan, Sabine Hellwig, Ulrike Steiner, Shu-Ming Li, Wilhelm Boland, Eckhard Leistner, Kerstin Ploss

Publikováno v: Plant Physiology

Ergoline alkaloids occur in taxonomically unrelated taxa, such as fungi, belonging to the phylum Ascomycetes and higher plants of the family Convolvulaceae. The disjointed occurrence can be explained by the observation that plant-associated epibiotic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5944471529ceda0eb7c85e2ea87f867
https://doi.org/10.1104/pp.108.116699

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The Pdx1 family is structurally and functionally conserved between Arabidopsis thaliana and Ginkgo biloba

Autor: Christel Drewke, Hanjo Hellmann, Sutton Mooney, Agnieszka Szewczyk, Andreas Genau, Jan Erik Leuendorf, Eckhard Leistner

Publikováno v: FEBS Journal. 275:960-969

Vitamin B6 is one of the most important compounds in living organisms, and its biosynthesis has only recently been understood. Because it is required for more than 100 biochemical reactions, lack of the vitamin is fatal. This is of special importance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1c8bb152002c981005b79ae46cdd9db
https://doi.org/10.1111/j.1742-4658.2008.06275.x

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The human pyridoxal kinase, a plausible target for ginkgotoxin fromGinkgo biloba

Autor: Michael Wiese, Uta Kästner, Christian Hallmen, Christel Drewke, Eckhard Leistner

Publikováno v: The FEBS Journal. 274:1036-1045

Ginkgotoxin (4′-O-methylpyridoxine) occurring in the seeds and leaves of Ginkgo biloba, is an antivitamin structurally related to vitamin B6. Ingestion of ginkgotoxin triggers epileptic convulsions and other neuronal symptoms. Here we report on stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2a2006893b68b90a705794cc54cbe65d
https://doi.org/10.1111/j.1742-4658.2007.05654.x

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