Engineering paralog-specific PSD-95 recombinant binders as minimally interfering multimodal probes for advanced imaging techniques

Autor: Charlotte Rimbault, Christelle Breillat, Benjamin Compans, Estelle Toulmé, Filipe Nunes Vicente, Monica Fernandez-Monreal, Patrice Mascalchi, Camille Genuer, Virginia Puente-Muñoz, Isabel Gauthereau, Eric Hosy, Stéphane Claverol, Gregory Giannone, Ingrid Chamma, Cameron D Mackereth, Christel Poujol, Daniel Choquet, Matthieu Sainlos

Publikováno v: eLife, Vol 13 (2024)

Despite the constant advances in fluorescence imaging techniques, monitoring endogenous proteins still constitutes a major challenge in particular when considering dynamics studies or super-resolution imaging. We have recently evolved specific protei

Externí odkaz: https://doaj.org/article/af2974b93e6049679cbad36b607c5248

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport

Autor: María-Victoria Hinckelmann, Amandine Virlogeux, Christian Niehage, Christel Poujol, Daniel Choquet, Bernard Hoflack, Diana Zala, Frédéric Saudou

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

How neurons produce energy to fuel fast axonal transport is only partially understood. Authors here report that most glycolytic enzymes are enriched in motile vesicles, and such glycolytic machinery can produce ATP autonomously to propel vesicle move

Externí odkaz: https://doaj.org/article/f0cf3b40a24c4fd88c6947f5f247fbd6

Engineering selective competitors for the discrimination of highly conserved protein-protein interaction modules

Autor: Daniel Choquet, Kashyap Maruthi, Christelle Breillat, Isabel Gauthereau, Matthieu Sainlos, Stéphane Claverol, Ségolène Antoine, Coraline Thibaut, Cameron D. Mackereth, Benjamin Dartigues, Christel Poujol, Charlotte Rimbault, Camille Genuer, Fabienne Wong Jun Tai, Sara Crespillo, Ingrid Chamma, Virginia Puente-Muñoz, Dolors Grillo-Bosch

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.4521. ⟨10.1038/s41467-019-12528-4⟩
DOAJ-Articles
Datacite
Hyper Article en Ligne
PubMed Central
Mémoires en Sciences de l'Information et de la Communication
UnpayWall
ORCID
Microsoft Academic Graph
HAL-Inserm
Nature Communications, 2019, 10 (1), pp.4521. ⟨10.1038/s41467-019-12528-4⟩

Developing inhibitors that target specific protein-protein interactions (PPIs) is challenging. Here, the authors show that target selectivity and PPI blocking can be achieved simultaneously with PPI inhibitors that contain two functional modules, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a0830dd8888ab0862373c88a22f40e1
https://doaj.org/article/bccf7dc6c979424398f916ba76abb566

Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport

Autor: Frédéric Saudou, Amandine Virlogeux, Christel Poujol, Christian Niehage, Daniel Choquet, Maria-Victoria Hinckelmann, Bernard Hoflack, Diana Zala

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications

The glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) facilitates fast axonal transport in neurons. However, given that GAPDH does not produce ATP, it is unclear whether glycolysis per se is sufficient to propel vesicles. Although ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4991fe9e8b7718218a07326502d15af
https://doaj.org/article/f0cf3b40a24c4fd88c6947f5f247fbd6

Neurexin-Neuroligin Adhesions Capture Surface-Diffusing AMPA Receptors through PSD-95 Scaffolds

Autor: Christel Poujol, Olivier Thoumine, Eric Hosy, Christophe Blanchet, Béatrice Tessier, Magali Mondin, Virginie F. Labrousse, Martin Heine, Florian Levet, Daniel Choquet

Publikováno v: Journal of Neuroscience

The mechanisms governing the recruitment of functional glutamate receptors at nascent excitatory postsynapses following initial axon-dendrite contact remain unclear. We examined here the ability of neurexin/neuroligin adhesions to mobilize AMPA-type

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed7d9d0f7efe1df9bf0dd72e4adf88b
https://doi.org/10.1523/jneurosci.6439-10.2011