Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions

Autor: Tomás Sou, Fadi Soukarieh, Paul Williams, Michael J. Stocks, Miguel Cámara, Christel A. S. Bergström

Publikováno v: ACS Omega, Vol 5, Iss 40, Pp 25733-25746 (2020)

Externí odkaz: https://doaj.org/article/8fc0ab8dfe114ac9afca9ea00c4b3da8

Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin

Autor: Aleksei Kabedev, Xuezhi Zhuo, Donglei Leng, Vito Foderà, Min Zhao, Per Larsson, Christel A. S. Bergström, Korbinian Löbmann

Publikováno v: Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing mechanisms of β-lactoglobulin in amorphous solid dispersions of indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922-3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397
Kabedev, A, Zhuo, X, Leng, D, Foderà, V, Zhao, M, Larsson, P, Bergström, C A S & Löbmann, K 2022, ' Stabilizing Mechanisms of β-Lactoglobulin in Amorphous Solid Dispersions of Indomethacin ', Molecular Pharmaceutics, vol. 19, no. 11, pp. 3922–3933 . https://doi.org/10.1021/acs.molpharmaceut.2c00397

Proteins, and in particular whey proteins, have recently been introduced as a promising excipient class for stabilizing amorphous solid dispersions. However, despite the efficacy of the approach, the molecular mechanisms behind the stabilization of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde64920fa1849af9775aa78cee253cc
https://doi.org/10.1021/acs.molpharmaceut.2c00397

Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug–Drug Interactions

Autor: Irina E. Antonescu, Maria Karlgren, Maria L. Pedersen, Ivailo Simoff, Christel A. S. Bergström, Sibylle Neuhoff, Per Artursson, Bente Steffansen, Carsten Uhd Nielsen

Publikováno v: Pharmaceutics, Vol 12, Iss 4, p 390 (2020)

Acamprosate is an anionic drug substance widely used in treating symptoms of alcohol withdrawal. It was recently shown that oral acamprosate absorption is likely due to paracellular transport. In contrast, little is known about the eliminating mechan

Externí odkaz: https://doaj.org/article/98594dfdbdd9410b820f985d165d6cfa

Intrinsic lipolysis rate for systematic design of lipid-based formulations

Autor: Ann-Christin, Jacobsen, Aleksei, Kabedev, Patrick D, Sinko, Johan E, Palm, Christel A S, Bergström, Alexandra, Teleki

Publikováno v: Drug delivery and translational research.

Lipid-based formulations (LBFs) are used by the pharmaceutical industry in oral delivery systems for both poorly water-soluble drugs and biologics. Digestibility is key for the performance of LBFs and in vitro lipolysis is commonly used to compare th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8d50b3f592308eec9105d1cfcb3d1017
https://pubmed.ncbi.nlm.nih.gov/36209313

Celebrating Women in the Pharmaceutical Sciences

Autor: Feng Qian, Christel A. S. Bergström, Raj Suryanarayanan, Kristofer J. Thurecht, Lynne S. Taylor, Afsaneh Lavasanifar

Publikováno v: Molecular Pharmaceutics. 18:1487-1490

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4c5069354927a809a77b5e71817bfe
https://doi.org/10.1021/acs.molpharmaceut.0c01197