Výsledky vyhledávání - "Christa Trexler"

Akademický článek

Inositol 1,4,5‐Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation

Autor: Qingsong Lin, Lingyun Zhao, Ran Jing, Christa Trexler, Hong Wang, Yali Li, Huayuan Tang, Fang Huang, Fei Zhang, Xi Fang, Jie Liu, Nan Jia, Ju Chen, Kunfu Ouyang

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 4 (2019)

Background Endothelial NO synthase plays a central role in regulating vasodilation and blood pressure. Intracellular Ca2+ mobilization is a critical modulator of endothelial NO synthase function, and increased cytosolic Ca2+ concentration in endothel

Externí odkaz: https://doaj.org/article/c6b82a14265f49d38eef5c5a27cd2fec

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Atypical ALPK2 kinase is not essential for cardiac development and function

Autor: Matthew Daniel Yu, Ju Chen, Lunfeng Zhang, Simone Spinozzi, Wei Feng, Yusu Gu, Serena Huang, Christa Trexler, Julijus Bogomolovas

Publikováno v: Am J Physiol Heart Circ Physiol

Protein kinases play an integral role in cardiac development, function, and disease. Recent experimental and clinical data have implied that protein kinases belonging to a family of atypical α-protein kinases, including α-protein kinase 2 (ALPK2),

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ec5bdce7f36dd556da1c5d52ec2a124
https://doi.org/10.1152/ajpheart.00249.2020

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Deletion of heat shock protein 60 in adult mouse cardiomyocytes perturbs mitochondrial protein homeostasis and causes heart failure

Autor: Xi Fang, Lei Huang, Feili Yang, Ju Chen, Feifei Fan, Huayuan Tang, Christa Trexler, Yali Li, Yaoyun Duan, Gang Wang, Kunfu Ouyang, Nan Jia, Jie Liu, Hong Wang

Publikováno v: Cell death and differentiation, vol 27, iss 2
Cell Death and Differentiation

To maintain healthy mitochondrial enzyme content and function, mitochondria possess a complex protein quality control system, which is composed of different endogenous sets of chaperones and proteases. Heat shock protein 60 (HSP60) is one of these mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cac42db43bbf2b5ed47d684539e08f
https://doi.org/10.1038/s41418-019-0374-x

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Cardiac Fibroblasts Mediate a Sexually Dimorphic Fibrotic Response to β-Adrenergic Stimulation

Autor: Cierra J. Walker, Angela K. Peter, Christa Trexler, Amy R. Perry, Leslie A. Leinwand, Tova L. Ceccato, Kristi S. Anseth, Christopher D Ozeroff, Kimberly R Lugo

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 11 (2021)
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Biological sex is an important modifier of cardiovascular disease and women generally have better outcomes compared with men. However, the contribution of cardiac fibroblasts (CFs) to this sexual dimorphism is relatively unexplored. Method

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3fd82539390d3ec6c84c89c442f301f
https://pubmed.ncbi.nlm.nih.gov/34045726

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Deletion of IP3R1 by Pdgfrb-Cre in mice results in intestinal pseudo-obstruction and lethality

Autor: Siting Zhu, Kunfu Ouyang, Xi Fang, Beili Zhao, Huayuan Tang, Ju Chen, Ran Jing, Christa Trexler, Yali Li, Jie Liu, Hong Wang, Zhixiang Pan

Publikováno v: Journal of gastroenterology, vol 54, iss 5

BackgroundInositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of intracellular Ca2+ release channels located on the membrane of endoplasmic reticulum, which have been shown to play critical roles in various cellular and physiological function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::272b1cd726c6eb56ac94dde9ca8f28fb
https://doi.org/10.1007/s00535-018-1522-7

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Ushering in the cardiac role of Ubiquilin1

Autor: Christa Trexler, Xi Fang, Ju Chen

Publikováno v: Journal of Clinical Investigation. 128:5195-5197

Protein quality control (PQC) mechanisms are essential for maintaining cardiac function, and alterations in this pathway influence multiple forms of heart disease. Since heart disease is the leading cause of death worldwide, understanding how the del

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::038557ef0987f34d1cb83ef18a3090ce
https://doi.org/10.1172/jci124567

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Inositol 1,4,5‐Trisphosphate Receptors in Endothelial Cells Play an Essential Role in Vasodilation and Blood Pressure Regulation

Autor: Ju Chen, Kunfu Ouyang, Xi Fang, Nan Jia, Christa Trexler, Yali Li, Fei Zhang, Jie Liu, Hong Wang, Lingyun Zhao, Qingsong Lin, Ran Jing, Fang Huang, Huayuan Tang

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

Background Endothelial NO synthase plays a central role in regulating vasodilation and blood pressure. Intracellular Ca 2+ mobilization is a critical modulator of endothelial NO synthase function, and increased cytosolic Ca 2+ concentration in endoth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f3c494a79d438fd889ed7599c17ce56
http://europepmc.org/articles/PMC6405661

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Deletion of IP

Autor: Hong, Wang, Ran, Jing, Christa, Trexler, Yali, Li, Huayuan, Tang, Zhixiang, Pan, Siting, Zhu, Beili, Zhao, Xi, Fang, Jie, Liu, Ju, Chen, Kunfu, Ouyang

Publikováno v: J Gastroenterol

BACKGROUND: Inositol 1,4,5-trisphosphate receptors (IP(3)Rs) are a family of intracellular Ca(2+) release channels located on the membrane of endoplasmic reticulum, which have been shown to play critical roles in various cellular and physiological fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fcfebcfca112674d2c12ee3dd5352ba0
https://pubmed.ncbi.nlm.nih.gov/30382364

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Abstract 266: Sex Differences in Survival and Pathological Responses of Hearts, Cardiac Myocytes and Fibroblasts

Autor: Leslie A. Leinwand, Kimberly R Lugo, Kristi S. Anseth, Angela K. Peter, Christopher D Ozeroff, Tova Christensen, Amy R. Perry, Cierra J. Walker, Christa Trexler

Publikováno v: Circulation Research. 123

Introduction: Biological sex is an important modifier of cardiovascular disease (CVD). However, women and female animals have traditionally been excluded from clinical trials and most preclinical research studies, resulting in therapeutics that are n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0f0a16bf306069278b1eb26519ba098
https://doi.org/10.1161/res.123.suppl_1.266

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Transcriptome and Functional Profile of Cardiac Myocytes Is Influenced by Biological Sex

Autor: Mark Y. Jeong, Robin D. Dowell, Aaron T. Odell, Leslie A. Leinwand, Christa Trexler

Publikováno v: Circulation: Cardiovascular Genetics. 10

Background— Although cardiovascular disease is the primary killer of women in the United States, women and female animals have traditionally been omitted from research studies. In reports that do include both sexes, significant sexual dimorphisms h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef640ab86f554153f32bd43f4ff6fc69
https://doi.org/10.1161/circgenetics.117.001770

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