Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christa Mattern"'
Autor:
John J. Renger, Joyce Stellabott, Swati P. Mercer, Wei Lemaire, Thomas S. Reger, Christopher D. Cox, Pamela L. Tannenbaum, Christopher J. Winrow, Joanne Stevens, Donghui Cui, Joseph G. Bruno, Susan L. Garson, Rowena V. Cube, M. Christa Mattern, Dansu Li, C. Meacham Harrell, Paul J. Coleman, John D. Schreier, Tamara D. Cabalu, George D. Hartman, Anthony L. Gotter, Steven V. Fox, Jeffrey M. Bergman, Anthony J. Roecker, Thomayant Prueksaritanont, Steven D. Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:4884-4890
Orexin receptor antagonists have demonstrated clinical utility for the treatment of insomnia. The majority of clinical efforts to date have focused on the development of dual orexin receptor antagonists (DORAs), small molecules that antagonize both t
Autor:
Rowena V. Cube, Cindy E. Nuss, Thomayant Prueksaritanont, Scott M. Doran, Jim Small, Wei Zeng, Julie Ann Luk, Cynthia Chavez-Eng, William O. Cook, T Laethem, Victor N. Uebele, Susan L. Garson, Thomas S. Reger, Richard L. Kraus, Yuhsin Kuo, Christa Mattern, Wei Fang, Cuyue Tang, John J. Renger, Paul J. Coleman, Kelly Ann S. Schlegel, Adekemi B. Taylor, Yuxing Li, Zhi Qiang Yang, James C. Barrow, Shu Youheng, Jeanine E. Ballard, Matthew D. Troyer, George D. Hartman, Steven V. Fox
Publikováno v:
ACS Medicinal Chemistry Letters. 1:504-509
A novel phenyl acetamide series of short-acting T-type calcium channel antagonists has been identified and evaluated using in vitro and in vivo assays. Heterocycle substitutions of the 4-position of the phenyl acetamides afforded potent and selective
Autor:
Cindy E. Nuss, Thomayant Prueksaritanont, Jeanine E. Ballard, John J. Renger, Yuhsin Kuo, Steven V. Fox, Rowena V. Cube, Thomas S. Reger, Shu Youheng, James C. Barrow, Kelly Ann S. Schlegel, George D. Hartman, Cuyue Tang, Georgia B. McGaughey, Yuxing Li, Zhi Qiang Yang, Victor N. Uebele, Christa Mattern, Scott M. Doran, Susan L. Garson, Richard L. Kraus, Kenneth E. Rittle
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(6)
A novel series of amide T-type calcium channel antagonists were prepared and evaluated using in vitro and in vivo assays. Optimization of the screening hit 3 led to identification of the potent and selective T-type antagonist 37 that displayed in viv
Autor:
Lee C. Speight, Robert J. Hinkle, Yajing Lian, Heather E. Stevenson, Melissa M. Sprachman, M. Christa Mattern, Lauren A. Katkish
Publikováno v:
Tetrahedron. 65(34)
The rapid synthesis of cis-2,6-disubstituted dihydropyrans is achieved in a three-component, one-pot cascade reaction. BiBr(3)-ediated addition of ketene silyl acetals or silyl enol ethers to beta,gamma-unsaturated cis-4-trimethylsilyl-3-butenal prov
Autor:
Lee C. Speight, M. Christa Mattern, Melissa M. Sprachman, Lauren A. Katkish, Yajing Lian, Heather E. Stevenson, Robert J. Hinkle
Publikováno v:
ChemInform. 40
The rapid synthesis of cis-2,6-disubstituted dihydropyrans is achieved in a three-component, one-pot cascade reaction. BiBr(3)-ediated addition of ketene silyl acetals or silyl enol ethers to beta,gamma-unsaturated cis-4-trimethylsilyl-3-butenal prov