Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Christa M. Musial"'
Discovery, synthesis, and structure–activity studies of tetrazole based growth hormone secretagogues
Autor:
David A. Gordon, Christa M. Musial, R. Krishna Seethala, Leah Giupponi, Kenneth E.J. Dickinson, Jeffrey A. Robl, Peter T. W. Cheng, Neil Flynn, Mark A. Smith, Dorothy Slusarchyk, Joseph A. Tino, Brian J. Murphy, Stephen G. Swartz, Gary J. Grover, Andres S. Hernandez, R.J. George, Daniel Longhi, Scott A. Biller
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:5928-5933
A novel class of Growth Hormone Secretagogues (GHS), based on a tetrazole template, has been discovered. In vitro SAR and in vivo potency within this new class of GHS are described. The tetrazole 9q exhibits good oral bioavailability in rats and dogs
Autor:
Neil Flynn, Hongjian Zhang, Leah Giupponi, Joseph A. Tino, Dorothy Slusarchyk, Steve Swartz, Haixia Wang, James J. Li, Ramakrishna Seethala, Shiwei Tao, Christa M. Musial, Brian J. Murphy, William G. Humphreys, Gary J. Grover, Andres A. Hernandez, Kenneth E.J. Dickinson, Mujing Yan, David A. Gordon, Jeffrey A. Robl, Blake C. Beehler, Stephanie Y. Chen, Paul G. Sleph, William R. Ewing, Jun Li
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(6)
The structure-activity relationship of the O-benzyl serine side chain was investigated based on the tetrazole-based growth hormone secretagogue BMS-317180 (2). The ortho position of the benzyl moiety was found to be favorable for introduction of subs
Autor:
Mujing Yan, Jeffrey A. Robl, Hongjian Zhang, Haixia Wang, Ramakrishna Seethala, Christa M. Musial, Bharat P. Patel, David A. Gordon, Terry R. Stouch, James J. Li, Kenneth E.J. Dickinson, Peter T. W. Cheng, Blake C. Beehler, Brian J. Murphy, Jun Li, Leah Giupponi, Shiwei Tao, Fucheng Qu, Gary J. Grover, Joseph A. Tino, Sam T. Chao, Mark A. Smith, William G. Humphreys, Neil Flynn, Dorothy Slusarchyk, William R. Ewing, Stephanie Y. Chen, Andres S. Hernandez, Stephen G. Swartz, Mark D. Schwinden, Paul G. Sleph, Scott A. Biller
Publikováno v:
Journal of medicinal chemistry. 50(24)
A tetrazole-based peptidomimetic 2 (BMS-317180) was discovered as a human growth hormone secretagogue (GHS). Compound 2 is a potent, novel, orally effective GHS that shows an excellent safety profile in preclinical studies. The compound was advanced
Autor:
Brian J. Murphy, Melissa Kung, Fucheng Qu, James J. Li, Gary J. Grover, Kenneth E.J. Dickinson, Neil Flynn, Dorothy Slusarchyk, Haixia Wang, David A. Gordon, Joseph A. Tino, Paul G. Sleph, Robert H. Stoffel, Ramakrishna Seethala, Leah Giupponi, Jeffrey A. Robl, Christa M. Musial, Rajasree Golla
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(7)
Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized
Autor:
Jun Li, Stephanie Y. Chen, James J. Li, Haixia Wang, Andres S. Hernandez, Shiwei Tao, Christa M. Musial, Fucheng Qu, Stephen Swartz, Sam T. Chao, Neil Flynn, Brian J. Murphy, Dorothy A. Slusarchyk, Ramakrishna Seethala, Mujing Yan, Paul Sleph, Gary Grover, Mark A. Smith, Blake Beehler, Leah Giupponi
Publikováno v:
Journal of Medicinal Chemistry; Nov2007, Vol. 50 Issue 24, p5890-5893, 4p