Výsledky vyhledávání - "Christa Litschko"

Akademický článek

Mix-and-Match System for the Enzymatic Synthesis of Enantiopure Glycerol-3-Phosphate-Containing Capsule Polymer Backbones from Actinobacillus pleuropneumoniae , Neisseria meningitidis , and Bibersteinia trehalosi

Autor: Christa Litschko, Insa Budde, Monika Berger, Andrea Bethe, Julia Schulze, E. Alberto Alcala Orozco, Reza Mahour, Peter Goettig, Jana Indra Führing, Thomas Rexer, Rita Gerardy-Schahn, Mario Schubert, Timm Fiebig

Publikováno v: mBio, Vol 12, Iss 3 (2021)

Economic synthesis platforms for the production of animal vaccines could help reduce the overuse and misuse of antibiotics in animal husbandry, which contributes greatly to the increase of antibiotic resistance. Here, we describe a highly versatile,

Externí odkaz: https://doaj.org/article/5722c046760342c281fde9f8456cbd10

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Akademický článek

Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinant Escherichia coli using high cell density cultivation

Autor: Bastian Bartling, Nora C. Brüchle, Johanna S. Rehfeld, Daniel Boßmann, Timm Fiebig, Christa Litschko, Jörg Fohrer, Rita Gerardy-Schahn, Thomas Scheper, Sascha Beutel

Publikováno v: Biotechnology Reports, Vol 28, Iss , Pp e00562- (2020)

Polysialic acid (polySia) are α2,8- and/or α2,9-linked homopolymers with interesting properties for meningococcal vaccine development or the cure of human neurodegenerative disorders.With the goal to avoid large scale production of pathogenic bacte

Externí odkaz: https://doaj.org/article/4abf18cab69c4f63a199e0ddfaf6e1d0

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Akademický článek

A New Family of Capsule Polymerases Generates Teichoic Acid-Like Capsule Polymers in Gram-Negative Pathogens

Autor: Christa Litschko, Davide Oldrini, Insa Budde, Monika Berger, Jochen Meens, Rita Gerardy-Schahn, Francesco Berti, Mario Schubert, Timm Fiebig

Publikováno v: mBio, Vol 9, Iss 3 (2018)

ABSTRACT Group 2 capsule polymers represent crucial virulence factors of Gram-negative pathogenic bacteria. They are synthesized by enzymes called capsule polymerases. In this report, we describe a new family of polymerases that combine glycosyltrans

Externí odkaz: https://doaj.org/article/6c00b5c8ad3940f2af66b90fac7376c3

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Accelerated production of α2,8- and α2,9-linked polysialic acid in recombinant Escherichia coli using high cell density cultivation

Autor: Daniel Boßmann, Nora C. Brüchle, Jörg Fohrer, Timm Fiebig, Christa Litschko, Rita Gerardy-Schahn, Bastian Bartling, Johanna S. Rehfeld, Thomas Scheper, Sascha Beutel

Publikováno v: Biotechnology Reports, Vol 28, Iss, Pp e00562-(2020)

Polysialic acid (polySia) are α2,8- and/or α2,9-linked homopolymers with interesting properties for meningococcal vaccine development or the cure of human neurodegenerative disorders. With the goal to avoid large scale production of pathogenic bact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144d08c4c08bf87f6aa975ceb61b31f9
http://www.sciencedirect.com/science/article/pii/S2215017X2030597X

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Erratum for Litschko et al., 'A New Family of Capsule Polymerases Generates Teichoic Acid-Like Capsule Polymers in Gram-Negative Pathogens'

Autor: Monika Berger, Insa Budde, Davide Oldrini, Timm Fiebig, Mario Schubert, Francesco Berti, Christa Litschko, Jochen Meens, Rita Gerardy-Schahn

Publikováno v: mBio, Vol 11, Iss 5 (2020)
mBio

Group 2 capsule polymers represent crucial virulence factors of Gram-negative pathogenic bacteria. They are synthesized by enzymes called capsule polymerases. In this report, we describe a new family of polymerases that combine glycosyltransferase an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eefb55db341faff3132abff604c67c6
https://journals.asm.org/doi/10.1128/mBio.02433-20

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Exploitation of Capsule Polymerases for Enzymatic Synthesis of Polysaccharide Antigens Used in Glycoconjugate Vaccines

Autor: Christa, Litschko, Insa, Budde, Monika, Berger, Timm, Fiebig

Publikováno v: Methods in molecular biology (Clifton, N.J.). 2183

The exploitation of recombinant enzymes for the synthesis of complex carbohydrates is getting increasing attention. Unfortunately, the analysis of the resulting products often requires advanced methods like nuclear magnetic resonance spectroscopy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cc624c39375bb56278d473fc7a58897b
https://pubmed.ncbi.nlm.nih.gov/32959251

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An enzyme-based protocol for cell-free synthesis of nature-identical capsular oligosaccharides from

Autor: Insa, Budde, Christa, Litschko, Jana I, Führing, Rita, Gerardy-Schahn, Mario, Schubert, Timm, Fiebig

Publikováno v: J Biol Chem

Actinobacillus pleuropneumoniae (App) is the etiological agent of acute porcine pneumonia and responsible for severe economic losses worldwide. The capsule polymer of App serotype 1 (App1) consists of [4)-GlcNAc-β(1,6)-Gal-α-1-(PO(4)-] repeating un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::222457c68bcabd5654535b34addf64f7
https://pubmed.ncbi.nlm.nih.gov/32152227

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