Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Christa L Hladik"'
Autor:
Jack M Raisanen, Christa L. Hladik, Charles L. White, Emily Herndon, Ping Shang, Dennis K. Burns
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 68:250-261
A pathologic hallmark of Huntington disease (HD) is the presence of intraneuronal aggregates of polyglutamine-containing huntingtin protein fragments. Monoclonal antibody 1C2 is a commercial antibody to normal human TATA-binding protein that detects
Autor:
Manuel Buttini, Takeshi Iwatsubo, Ronald L. Hamilton, Federico Roncaroli, James B. Leverenz, Charles H. Adler, Joseph V. Noorigian, Thomas G. Beach, Dennis W. Dickson, Christa L. Hladik, Charles L. White, Lucia I. Sue, John E. Duda
Publikováno v:
Acta Neuropathologica. 116:277-288
The use of alpha-synuclein immunohistochemistry has altered our concepts of the cellular pathology, anatomical distribution and prevalence of Lewy body disorders. However, the diversity of methodology between laboratories has led to some inconsistenc
Autor:
Ampa Luangpirom, Ingrid Mudrak, Lisa Montgomery, Christa L. Hladik, Estelle Sontag, Charles L. White, Egon Ogris
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 63:1080-1091
ABalphaC, a major protein phosphatase 2A (PP2A) heterotrimeric enzyme, binds to and regulates the microtubule cytoskeleton and tau. We have shown that ABalphaC protein expression levels are selectively reduced in Alzheimer disease (AD). Notably, the
Autor:
Ampa Luangpirom, Samuel G. Speciale, Christa L. Hladik, Charles L. White, Ingrid Mudrak, Egon Ogris, Estelle Sontag
Publikováno v:
Journal of Neuropathology & Experimental Neurology. 63:287-301
The formation of amyloid-containing senile plaques and tau-rich neurofibrillary tangles are central events in Alzheimer disease (AD) pathogenesis. Significantly, ABalphaC, a major protein phosphatase 2A (PP2A) holoenzyme, specifically binds to and de
Publikováno v:
Ophthalmology. 111:822-827
Objective The pathologic markers of nonaccidental injury (NAI) of the central nervous system (CNS) of infants and young children include subdural, subarachnoid, and retinal hemorrhages. Immunohistochemical staining for β-amyloid precursor protein (
Publikováno v:
Journal of Neurotrauma. 20:347-355
Immunohistochemical staining for beta-amyloid precursor protein (betaAPP) is a well-established marker of traumatic axonal injury in adults. Recent studies have used similar techniques to evaluate nonaccidental central nervous system injury (NAI) in
Autor:
James A. Richardson, Susana Velasco-Miguel, Tianshu Gao, Wayne C. Lai, Errol C. Friedberg, Lonnie D. Russell, Christa L. Hladik, Charles L. White, Valerie L. Gerlach
Publikováno v:
DNA Repair. 2:91-106
A recently discovered group of novel polymerases are characterized by significantly reduced fidelity of DNA synthesis in vitro. This feature is consistent with the relaxed fidelity required for the replicative bypass of various types of base damage t
Autor:
Dominik Schenten, Susana Velasco-Miguel, Christa L. Hladik, Charles L. White, Klaus Rajewsky, Gloria Esposito, Caixia Guo, Errol C. Friedberg, Valerie L. Gerlach
Publikováno v:
European Journal of Immunology. 32:3152-3160
Somatic hypermutation (SH) in B cells undergoing T cell-dependent immune responses generates high-affinity antibodies that provide protective immunity. Most current models of SH postulate the introduction of a nick into the DNA and subsequent replica
Autor:
Daniel F. Brown, Erin Welch, Richard C. Risser, Ashley Stiegler, Kathleen P. Eagan, Patrick Tripp, Eileen H. Bigio, Christa L. Hladik, Charles L. White
Publikováno v:
Journal of Neuropathology and Experimental Neurology. 57:955-960
Substantial numbers of cortical and subcortical Lewy bodies are seen in approximately one quarter of patients whose brains show sufficient histopathologic changes for a neuropathologic diagnosis of definite Alzheimer disease (AD). This subset of case
Autor:
Joseph B. Joie, Christa L. Hladik, Freida L. Carson, William W. Stigliano, Bonnie P. Whitaker, Joseph A. Lynn, Roxana J. Robinson
Publikováno v:
Journal of Histotechnology. 17:105-109
An 0.1 125% zinc chloride, 50% isopropyl alcoholic, 10% unbuffered formalin postfixative for routine surgical pathology tissues is described. Integration of this zinc isopropyl alcoholic formalin postfixative into all automated routine tissue process