Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Christa Hegele-Hartung"'
Autor:
Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, Derek J. Leishman
Publikováno v:
Clinical Pharmacology and Therapeutics
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide. In use for over 15 years
Autor:
Stefan Gradl, Sooncheol Lee, Martin Lange, Xiaoyun Wu, Silvia Goldoni, Timothy Lewis, Charlotte Kopitz, Colin Garvie, Philip Lienau, Stephanie Hoyt, Henrik Seidel, Stephan Kaulfuss, Manuel Ellermann, Luc de Waal, Adrian Tersteegen, Sven Golfier, Detlev Suelzle, Christa Hegele-Hartung, James Carr, Frederick Brookfield, Michael Bruening, Melanie Berthold, Thibaud Jourdan, Monica Schenone, Galen Gao, Joseph McGaunn, Antje Wengner, Elisa Aquilanti, Franziska Siegel, Marine Garrido, Annette Walter, Isabelle Genvresse, Andrew Cherniack, Stuart Schreiber, Knut Eis, Ashley Eheim, Matthew Meyerson, Heidi Greulich
Publikováno v:
Cancer Research. 82:ND04-ND04
Velcrin compounds are a class of small molecules that induce complex formation between PDE3A and SLFN12, killing cancer cells that express elevated levels of these two proteins by a mechanism independent of PDE3A enzymatic inhibition. Instead, PDE3A
Autor:
Christoph Stephan Hilger, Hubertus Pietsch, Markus Berger, Christian Neis, Christa Hegele-Hartung, Kaspar Hegetschweiler, Björn Riefke, Thomas Frenzel, Gregor Jost, Detlev Suelzle, Marcus Bauser
Publikováno v:
Investigative Radiology. 51:776-785
Characterization of BAY-576, a new x-ray contrast agent which is not based on iodine, but rather on the heavy metal hafnium. Compared with iodine, hafnium provides better x-ray absorption in the energy range of computed tomography (CT) and allows ima
Autor:
Olaf Döhr, Christa Hegele-Hartung, Ursula Mönning, Keith Graham, Ralf Lesche, Georg Kettschau, Ludger Dinkelborg, Sandra Borkowski, Alexey Gromov, Niels Böhnke
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 41:89-101
Prostate-specific membrane antigen (PSMA) is a transmembrane protein overexpressed in prostate cancer and is therefore being explored as a biomarker for diagnosing and staging of the disease. Here we report preclinical data on BAY 1075553 (a 9:1 mixt
Autor:
Hartmut Blode, Georg Ertl, Melanie Muehlfelder, Susan A. Elmore, Kai Hu, Robert R. Maronpot, Theo Pelzer, Paula-Anahi Arias-Loza, K. H. Fritzemeier, Christa Hegele-Hartung
Publikováno v:
Toxicologic Pathology. 37:969-982
Elevated mineralocorticoid levels and female sex hormones have been shown to confer opposing effects on renal injury, but their combined effects are still unknown. Objective: Identify the function of estrogens and of different synthetic progestins on
Autor:
Johann Bauersachs, K. H. Fritzemeier, Christa Hegele-Hartung, Theo Pelzer, Julian Widder, Ludwig Neyses, Christine von Poser-Klein, Georg Ertl, Virginija Jazbutyte, Kai Hu, Paula Anahi Arias-Loza, Vijayakumar Govindaraj
Publikováno v:
Cardiovascular Research. 77:774-781
The biological effects of oestrogens are mediated by two different oestrogen receptor (ER) subtypes, ERalpha and ERbeta, which might play different, redundant, or opposing roles in cardiovascular disease. Previously, we have shown that the selective
Publikováno v:
European Journal of Pharmacology. 566:222-225
We investigated the effects of hyperosmolar solutions on human ether-a-go-go related gene (hERG) potassium currents in chinese hamster ovary (CHO) cells. The addition of d-mannitol to the external solution caused cell shrinkage and reduced current am
Autor:
E. Vogt, B. Lindenthal, Christa Hegele-Hartung, Ursula Eichenlaub-Ritter, G. Michel, I. Betzendahl, S. Cukurcam
Publikováno v:
Human Reproduction. 22:815-828
BACKGROUND: Follicular fluid meiosis-activating sterol (FF-MAS) protects young oocytes from precocious chromatid separation (predivision). Reduced expression of cohesion and checkpoint proteins and predivision has been hypothesized to occur in age-re
Autor:
Johann Bauersachs, Jan Galle, Virginija Jazbutyte, Theo Pelzer, Andreas Schäfer, Christa Hegele-Hartung, Thomas Quaschning, Karl-Heinrich Fritzemeier, Georg Ertl, Kai Hu, Paula Anahi Arias-Loza, Ludwig Neyses
Publikováno v:
Hypertension. 48:994-1001
Controversial results obtained from human and animal studies on the prevention of heart disease by estrogens and progestins warrant a better understanding of nuclear hormone receptor function and interaction. To address this issue and taking into acc
Autor:
Jenny Muck, Stephan Segerer, Theo Pelzer, K. H. Fritzemeier, Christa Hegele-Hartung, Ludwig Neyses, Virginija Jazbutyte, Andreas Bonz, Peter Nordbeck, Georg Ertl, Matthias Nahrendorf, Kai Hu
Publikováno v:
Cardiovascular Research. 67:604-612
Cardiac mass increases with age and with declining estradiol serum levels in postmenopausal women. Although the non-selective estrogen receptor-alpha and -beta agonist 17beta-estradiol attenuates cardiac hypertrophy in animal models and in observatio