Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Christa Geeke, Toenhake"'
Autor:
Christa Geeke Toenhake, Annemarie Voorberg-van der Wel, Haoyu Wu, Abhishek Kanyal, Ivonne Geessina Nieuwenhuis, Nicole Maria van der Werff, Sam Otto Hofman, Anne-Marie Zeeman, Clemens Hendricus Martinus Kocken, Richárd Bártfai
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112727- (2023)
Summary: Dormancy enables relapsing malaria parasites, such as Plasmodium vivax and cynomolgi, to survive unfavorable conditions. It is enabled by hypnozoites, parasites remaining quiescent inside hepatocytes before reactivating and establishing bloo
Externí odkaz:
https://doaj.org/article/40a2644ce2bf4f22b778e3abd9a5c5c5
Autor:
Eilidh Carrington, Roel Henrikus Martinus Cooijmans, Dominique Keller, Christa Geeke Toenhake, Richárd Bártfai, Till Steffen Voss
Publikováno v:
iScience, Vol 24, Iss 5, Pp 102444- (2021)
Summary: Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression. Most ApiAP2 factors studied to date
Externí odkaz:
https://doaj.org/article/0bd3b1c519bf49c881da51fc3f4c4e1b
Autor:
Jessica Kimmel, Marius Schmitt, Alexej Sinner, Pascal Jansen, Sheila Mainye, Gala Ramón-Zamorano, Christa Geeke Toenhake, Jan Stephan Wichers, Jakob Cronshagen, Ricarda Sabitzki, Paolo Mesén-Ramírez, Hannah Michaela Behrens, Richárd Bártfai, Tobias Spielmann
Taxa-specific proteins are key determinants defining the biology of all organisms and represent prime drug targets in pathogens. However, lacking comparability with proteins in other lineages makes them particularly difficult to study. In malaria par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c43c87faf2068491bb7d23b25482e1f1
https://doi.org/10.1101/2022.07.07.499005
https://doi.org/10.1101/2022.07.07.499005
Autor:
Rob Henderson, Liwang Cui, Sabine Schmidt, Jun Miao, Christa Geeke Toenhake, Sonja Ghidelli-Disse, Jakob Birnbaum, Gerard Drewes, Sony Shrestha, Hendrik G. Stunnenberg, Tobias Spielmann, Richárd Bártfai, Jeron Venhuizen, Wieteke A. M. Hoeijmakers
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 47, 11574-11588
Nucleic Acids Research, 47, 22, pp. 11574-11588
Nucleic Acids Research, 47, 11574-11588
Nucleic Acids Research, 47, 22, pp. 11574-11588
Epigenetic regulatory mechanisms are central to the development and survival of all eukaryotic organisms. These mechanisms critically depend on the marking of chromatin domains with distinctive histone tail modifications (PTMs) and their recognition
Autor:
Eilidh, Carrington, Roel Henrikus Martinus, Cooijmans, Dominique, Keller, Christa Geeke, Toenhake, Richárd, Bártfai, Till Steffen, Voss
Publikováno v:
iScience. 24(5)
Malaria parasites undergo a complex life cycle in the human host and the mosquito vector. The ApiAP2 family of DNA-binding proteins plays a dominant role in parasite development and life cycle progression. Most ApiAP2 factors studied to date act as t
Autor:
Dominique Keller, Eilidh Carrington, Roel H. M. Cooijmans, Christa Geeke Toenhake, Richárd Bártfai, Till S. Voss
Malaria parasites undergo a highly complex life cycle in the human host and the mosquito vector. The ApiAP2 family of sequence-specific DNA-binding proteins plays a dominant role in parasite development and life cycle progression. Of the ApiAP2 facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1249cc91713e2a7221b11b0f8564cbb
https://doi.org/10.1101/2020.11.06.370338
https://doi.org/10.1101/2020.11.06.370338
Autor:
Wieteke A. M. Hoeijmakers, Alexandra Blancke Soares, Ulrike Fröhlke, Sabine Schmidt, Hendrik Herrmann, Paolo Mesén-Ramírez, Sven Flemming, Bärbel Bergmann, Sarah Scharf, Ernst Jonscher, Ricarda Sabitzki, Tobias Spielmann, Christa Geeke Toenhake, Jakob Birnbaum, Richárd Bártfai, Marius Schmitt
Publikováno v:
Science, 367, 6473, pp. 51-59
Science, 367, 51-59
Science, 367, 51-59
An artemisinin resistance mechanism Species of the malaria parasite Plasmodium live in red blood cells and possess a highly conserved gene called kelch13 . Single point mutations in this gene are associated with resistance to the frontline artemisini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee08cf2c64ddd134e53fa052b79c7763
https://hdl.handle.net/2066/216019
https://hdl.handle.net/2066/216019
Autor:
Matthew Berriman, Lia Chappell, Maaike Bras, Philip R. Kensche, Christa Geeke Toenhake, Wieteke A. M. Hoeijmakers, Richárd Bártfai
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, 44, 5, pp. 2110-24
Nucleic Acids Research, 44, 2110-24
Nucleic Acids Research, 44, 5, pp. 2110-24
Nucleic Acids Research, 44, 2110-24
In eukaryotes, the chromatin architecture has a pivotal role in regulating all DNA-associated processes and it is central to the control of gene expression. For Plasmodium falciparum, a causative agent of human malaria, the nucleosome positioning pro
Autor:
Christa Geeke, Toenhake, Sabine Anne-Kristin, Fraschka, Mahalingam Shanmugiah, Vijayabaskar, David Robert, Westhead, Simon Jan, van Heeringen, Richárd, Bártfai
Publikováno v:
Cell hostmicrobe. 23(4)
Underlying the development of malaria parasites within erythrocytes and the resulting pathogenicity is a hardwired program that secures proper timing of gene transcription and production of functionally relevant proteins. How stage-specific gene expr
Autor:
Igor Niederwieser, Angela Zou, Suzette Moes, Richárd Bártfai, Rob Henderson, Nicole L. Bertschi, John Parkinson, Paul Jenoe, Christa Geeke Toenhake, Till S. Voss
Publikováno v:
Nature Microbiology, 2, 1-12
Nature Microbiology, 2, pp. 1-12
Nature Microbiology, 2, pp. 1-12
Telomere repeat-binding factors (TRFs) are essential components of the molecular machinery that regulates telomere function. TRFs are widely conserved across eukaryotes and bind duplex telomere repeats via a characteristic MYB-type domain. Here, we i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::765a1beb0d8653cafb11a3c5efe5d76e
http://hdl.handle.net/2066/168890
http://hdl.handle.net/2066/168890