Výsledky vyhledávání - "Christa F. Nagy"

Safety, Pharmacokinetics, and Immunogenicity of Obiltoxaximab After Intramuscular Administration to Healthy Humans

Autor: Robert Guttendorf, Timothy S. Leach, Alex King, Christa F. Nagy

Publikováno v: Clinical Pharmacology in Drug Development

Inhalational anthrax is a highly lethal infection caused by Bacillus anthracis and a serious bioterrorism threat. Protective antigen (PA) is a critical component required for the virulence of Bacillus anthracis. Obiltoxaximab, a high‐affinity monoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa12649140788907f215ef9f5089c010
https://pubmed.ncbi.nlm.nih.gov/29125719

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Steady-state pharmacokinetics and safety of donepezil HCl in subjects with moderately impaired renal function

Autor: H. Wayne Hutman, Thomas Marbury, W. Kline Bolton, Dinesh Kumar, Christa F. Nagy, Maria Gutierrez, Raymond D. Pratt, Edward I. Cullen

Publikováno v: British Journal of Clinical Pharmacology. 58:18-24

To characterize the pharmacokinetic, pharmacodynamic and safety profiles of donepezil in subjects with moderate renal impairment and matched healthy controls during single-dose and multiple-dose phases.This open-label study enrolled subjects with mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40477e476f98c7f23677c2f1e6a029f1
https://doi.org/10.1111/j.1365-2125.2004.01803.x

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Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses

Autor: Dinesh Kumar, Edward I. Cullen, Carlos Perdomo, Christa F. Nagy, Raymond D. Pratt, Suman Wason

This study evaluated the safety and pharmacokinetics (PK) of donepezil HCl and sertraline HCl when administered separately and in combination.This was a randomized, open-label, three-period crossover study. In consecutive dosing periods separated by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7fa4eb040ecb0a5b8c6223216ce5571
https://europepmc.org/articles/PMC1884554/

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Pharmacokinetics and Tolerability of Obiltoxaximab: A Report of 5 Healthy Volunteer Studies

Autor: Christa F. Nagy, Robert Guttendorf, Arthur Czech, Joseph H. Hoffman, Timothy S. Leach, Sarah E. Carpenter

Publikováno v: Clinical Therapeutics. (9):2083-2097.e7

Purpose This report describes the safety, immunogenicity, and pharmacokinetic results of obiltoxaximab treatment in healthy subjects from 5 clinical trials. Methods Healthy men and women were enrolled in randomized, double-blind studies of obiltoxaxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f577a1f174ec4de991ca3c6c419b0bd

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