Inflammatory Kidney and Liver Tissue Response to Different Hydroxyethylstarch (HES) Preparations in a Rat Model of Early Sepsis.

Autor: Ralph C Schimmer, Martin Urner, Stefanie Voigtsberger, Christa Booy, Birgit Roth Z'Graggen, Beatrice Beck-Schimmer, Martin Schläpfer

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0151903 (2016)

Tissue hypoperfusion and inflammation in sepsis can lead to organ failure including kidney and liver. In sepsis, mortality of acute kidney injury increases by more than 50%. Which type of volume replacement should be used is still an ongoing debate.

Externí odkaz: https://doaj.org/article/c39a64e413e649848a35f16eea07646c

Hypoxia sensing by hepatic stellate cells leads to VEGF-dependent angiogenesis and may contribute to accelerated liver regeneration

Autor: Erik Schadde, Roland H. Wenger, Donat R. Spahn, Christa Booy, Vartan Kurtcuoglu, Rita Fatzer, Martin Schläpfer, Costica Aloman, Birke Bartosch, Romain Parent, Beatrice Beck Schimmer, Diane de Zélicourt, Konstantin Dirscherl, Birgit Roth Z'graggen, Renata Flury-Frei

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2020, 10 (1), pp.4392. ⟨10.1038/s41598-020-60709-9⟩
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, 2020, 10 (1), pp.4392. ⟨10.1038/s41598-020-60709-9⟩

Portal vein ligation (PVL) induces liver growth prior to resection. Associating liver partition and portal vein ligation (PVL plus transection=ALPPS) or the addition of the prolyl-hydroxylase inhibitor dimethyloxalylglycine (DMOG) to PVL both acceler

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799d356d45dcbec7cf9a268409b023c6
https://www.hal.inserm.fr/inserm-02510401/file/s41598-020-60709-9.pdf

Sevoflurane attenuates systemic inflammation compared with propofol, but does not modulate neuro-inflammation

Autor: Martin Schläpfer, Beatrice Beck-Schimmer, Christa Booy, Lukas Baumann, Melanie Hasler, Tanja Restin, Philipp Eugster

Publikováno v: European Journal of Anaesthesiology. 34:764-775

Septic encephalopathy is believed to be a result of neuro-inflammation possibly triggered by endotoxins, such as lipopolysaccharides (LPS). Modulation of the immune system is a property of volatile anaesthetics.We aimed to investigate the systemic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1802356b3aeca64775389c6b3d17396
https://doi.org/10.1097/eja.0000000000000668

Insight into the beneficial immunomodulatory mechanism of the sevoflurane metabolite hexafluoro-2-propanol in a rat model of endotoxaemia

Autor: Wendelin J. Stark, Richard D. Minshall, Martin Urner, Martin Schläpfer, R. R. Schimmer, B Roth Z'graggen, F. Aigner, Melanie Hasler, Christa Booy, Inge K. Herrmann, Beatrice Beck-Schimmer, Hubert Rehrauer

Publikováno v: Clinical and experimental immunology

Summary Volatile anaesthetics such as sevoflurane attenuate inflammatory processes, thereby impacting patient outcome significantly. Their inhalative administration is, however, strictly limited to controlled environments such as operating theatres,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0543d512c8c7c756e5cee20c155da81d
https://doi.org/10.1111/cei.12648

Sevoflurane abolishes oxygenation impairment in a long-term rat model of acute lung injury

Autor: Tobias Piegeler, Beatrice Beck-Schimmer, Patrick Kellner, Martin Schläpfer, Christa Booy, Philipp Eugster, Mattia Müller

BACKGROUND Patients experiencing acute lung injury (ALI) often need mechanical ventilation for which sedation may be required. In such patients, usually the first choice an intravenously administered drug. However, growing evidence suggests that vola

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3428ae6989fd839b234c891a06dd53d8
https://doi.org/10.5167/uzh-126974