Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christèle Frémaux"'
Publikováno v:
SLAS Discovery. 14:1008-1016
Kinases are key targets for drug discovery. In the field of screening in general and especially in the kinase area, because of considerations of efficiency and cost, radioactivity-based assays tend to be replaced by alternative, mostly fluorescenceba
Publikováno v:
ASSAY and Drug Development Technologies. 4:185-196
In the field of screening in general and especially in the kinase area, taking into consideration throughput and cost, fluorescence- and luminescence-based assays have been developed as alternatives to radioactivity-based assays. However, fluorescenc
Publikováno v:
Expert opinion on drug discovery. 5(1)
Importance of the field: Microfluidic electrophoretic mobility shift assays are becoming increasingly popular with screening groups throughout the pharmaceutical industry due to their excellent data quality and target flexibility.Areas covered in thi
Autor:
Gordon Campbell, Anna Quattropani, Agnes Bombrun, Christophe Cleva, Marilène Gaudet, Gwenaelle Bouscary-Desforges, Marc Missotten, Stefano Crosignani, Hamina Daff, Kamel El Harkani, Tania Grippi-Vallotton, Nada Abla, Christèle Frémaux, Catherine Jorand-Lebrun, Zoë Johnson, Yves Humbert, Olivier Schott, Jean-François Arrighi, Charles G. Bradshaw, Mikaël Pâquet, Adeline Pretre, Pittet Pierre-Andre
Publikováno v:
ACS medicinal chemistry letters. 2(12)
Antagonism of the CRTH2 receptor represents a very attractive target for a variety of allergic diseases. Most CRTH2 antagonists known to date possess a carboxylic acid moiety, which is essential for binding. However, potential acid metabolites O-acyl
Autor:
Dominique Perrin, Lara Joubert, Catherine Salvat, Isabelle Foucault, Bernard Françon, Hadi Abderrahim, Marc Lamarine, Catherine Jorand-Lebrun, Francisca Zanoguera, Rosanna Pescini Gobert, Marie Laure Curchod, Helene Peixoto, Agnes Bombrun, Lilia Bernasconi, Christian Rommel, Chantal Alliod, Rob Hooft van Huijsduijnen, Chloé Vignaud, Thérèse Jomotte, Christèle Frémaux
Publikováno v:
Molecular and cellular biology. 29(6)
Inadequate remyelination of brain white matter lesions has been associated with a failure of oligodendrocyte precursors to differentiate into mature, myelin-producing cells. In order to better understand which genes play a critical role in oligodendr
Autor:
Alexander Scheer, Christèle Frémaux, Wolfgang H. B. Sauer, Dominique Perrin, Dominique Besson
Publikováno v:
Journal of biomolecular screening. 11(8)
Protein tyrosine phosphatases (PTPs) play key roles in regulating tyrosine phosphorylation levels in cells. Since the discovery of PTP1B as a major drug target for diabetes and obesity, PTPs have emerged as a new and promising class of signaling targ
A homogeneous 384-well high-throughput binding assay for a TNF receptor using alphascreen technology
Autor:
Marie Kosco-Vilbois, Claudia Pena Rossi, Susanna Carboni, Claudio Soto, Dominique Perrin, Christèle Frémaux, Alexander Scheer, Janet Wilson
Publikováno v:
Journal of biomolecular screening. 8(5)
To take advantage of the growing knowledge of cellular signaling pathways, modern-daydrug discoveryfaces an increasing challenge to develop assays to screen for compounds that modulate protein-protein interactions. One bottleneck in achieving this go
Publikováno v:
Assay & Drug Development Technologies; Apr2006, Vol. 4 Issue 2, p185-196, 12p