Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Chrissa A Dwyer"'
Autor:
Patricia Aguilar-Calvo, Adela Malik, Daniel R Sandoval, Christopher Barback, Christina D Orrù, Heidi G Standke, Olivia R Thomas, Chrissa A Dwyer, Donald P Pizzo, Jaidev Bapat, Katrin Soldau, Ryotaro Ogawa, Mckenzie B Riley, K Peter R Nilsson, Allison Kraus, Byron Caughey, Jeffrey J Iliff, David R Vera, Jeffrey D Esko, Christina J Sigurdson
Publikováno v:
PLoS Pathogens, Vol 19, Iss 9, p e1011487 (2023)
Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet how HS impacts fibrillar
Externí odkaz:
https://doaj.org/article/c83e6fca89c54c42855f3b68597d0988
Autor:
Linde F. Bouwman, Bianca den Hamer, Anita van den Heuvel, Marnix Franken, Michaela Jackson, Chrissa A. Dwyer, Stephen J. Tapscott, Frank Rigo, Silvère M. van der Maarel, Jessica C. de Greef
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 813-827 (2021)
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent skeletal muscle dystrophies. Skeletal muscle pathology in individuals with FSHD is caused by inappropriate expression of the transcription factor DUX4, which activates differe
Externí odkaz:
https://doaj.org/article/72b1e161cd6e4f43899a64fac88d86d4
Autor:
Kie Yoshida-Tanaka, Hidetoshi Kaburagi, Kotaro Yoshioka, Naoto Arimura, Takanori Yokota, Frank Rigo, Toshiki Uchihara, Takashi Ishii, Kensuke Ihara, Kenichi Miyata, Haruka Miyata, Takeshi Wada, Kanjiro Miyata, Chrissa A. Dwyer, Punit P. Seth, Tetsuya Nagata, Rintaro Iwata Hara, Syunsuke Yamamoto, Hideki Hirabayashi, Satoe Ebihara, Tomoko Igari, C. Frank Bennett, Masaki Ohyagi, Berit Powers
Publikováno v:
Nature Biotechnology. 39:1529-1536
Achieving regulation of endogenous gene expression in the central nervous system (CNS) with antisense oligonucleotides (ASOs) administered systemically would facilitate the development of ASO-based therapies for neurological diseases. We demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea20dbc680bd2292680a38bb270a82d4
https://doi.org/10.1038/s41587-021-00972-x
https://doi.org/10.1038/s41587-021-00972-x
Autor:
Miguel Tillo, William C. Lamanna, Chrissa A. Dwyer, Daniel R. Sandoval, Ariane R. Pessentheiner, Norah Al-Azzam, Stéphane Sarrazin, Jon C. Gonzales, Shih-Hsin Kan, Alexander Y. Andreyev, Nicholas Schultheis, Bryan E. Thacker, Charles A. Glass, Patricia I. Dickson, Raymond Y. Wang, Scott B. Selleck, Jeffrey D. Esko, Philip L.S.M. Gordts
Publikováno v:
The Journal of biological chemistry, vol 298, iss 8
Lysosomal storage diseases result in various developmental and physiological complications, including cachexia. To study the causes for the negative energy balance associated with cachexia, we assessed the impact of sulfamidase deficiency and heparan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aac85804ae2331b1d014955f84e8ad4
https://escholarship.org/uc/item/90c4v3np
https://escholarship.org/uc/item/90c4v3np
Autor:
Brendon E. Cook, Jonathan Archbold, Khaled Nasr, Sara Girmay, Stanley I. Goldstein, Pei Li, Sivaraman Dandapani, Nathan E. Genung, Sac-Pham Tang, Stuart McClusky, Christophe Plisson, Megan E. Afetian, Chrissa A. Dwyer, Michael Fazio, William J. Drury, Frank Rigo, Laurent Martarello, Maciej Kaliszczak
Publikováno v:
Molecular imaging and biology. 24(6)
The treatment of complex neurological diseases often requires the administration of large therapeutic drugs, such as antisense oligonucleotide (ASO), by lumbar puncture into the intrathecal space in order to bypass the blood-brain barrier. Despite th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e72f918165f8a07d9d8a09a98a8da8
https://pubmed.ncbi.nlm.nih.gov/35655109
https://pubmed.ncbi.nlm.nih.gov/35655109
Autor:
Marnix Franken, Stephen J. Tapscott, Chrissa A. Dwyer, Frank Rigo, Linde F. Bouwman, Silvère M. van der Maarel, Bianca den Hamer, Michaela Jackson, Anita van den Heuvel, Jessica C. de Greef
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 26, Iss, Pp 813-827 (2021)
Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids, 26, 813-827. CELL PRESS
Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids, 26, 813-827. CELL PRESS
Facioscapulohumeral muscular dystrophy (FSHD) is one of the most prevalent skeletal muscle dystrophies. Skeletal muscle pathology in individuals with FSHD is caused by inappropriate expression of the transcription factor DUX4, which activates differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2126e723fbeed02abda095604d0d04
https://hdl.handle.net/1887/3256609
https://hdl.handle.net/1887/3256609
Autor:
Frank Rigo, Thazha P. Prakash, Chrissa A. Dwyer, Michaela Jackson, Michael Tanowitz, Mehran Nikan, Eric E. Swayze, Hans Gaus, Punit P. Seth
Publikováno v:
Journal of medicinal chemistry. 63(15)
Despite recent advances, targeted delivery of therapeutic oligonucleotide to extra-hepatic tissues continues to be a challenging endeavor and efficient ligand-receptor systems need to be identified. To determine the feasibility of using neurotensin t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cededc0e3e4293a336b52691ffdb4a1
https://pubmed.ncbi.nlm.nih.gov/32677436
https://pubmed.ncbi.nlm.nih.gov/32677436
Autor:
Philip L.S.M. Gordts, Stéphane Sarrazin, Yitzhak Tor, Gentry N. Patrick, Wenyong Tong, Lara E. Dozier, Chrissa A. Dwyer, Jeffrey D. Esko, Jillian R. Brown, Bryan E. Thacker, Kristina M. Hamill, Kelley W. Moremen, Charles A. Glass
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy, vol 25, iss 12
Iduronidase (IDUA)-deficient mice accumulate glycosaminoglycans in cells and tissues and exhibit many of the same neuropathological symptoms of patients suffering from Mucopolysaccharidosis I. Intravenous enzyme-replacement therapy forMucopolysacchar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb6ba12ecb593e8234fbe539fa76018
https://doi.org/10.1016/j.ymthe.2017.08.007
https://doi.org/10.1016/j.ymthe.2017.08.007
Autor:
Jeffrey D. Esko, Chrissa A. Dwyer
Publikováno v:
Molecular Aspects of Medicine. 51:104-114
Idiopathic autism spectrum disorders (ASDs) are neurodevelopmental disorders with unknown etiology. An estimated 1:68 children in the U.S. are diagnosed with ASDs, making these disorders a substantial public health issue. Recent advances in genome se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d69a01bddb96ca41c2a8915ab68264
https://doi.org/10.1016/j.mam.2016.07.001
https://doi.org/10.1016/j.mam.2016.07.001
Publikováno v:
Journal of Biological Chemistry. 290:10256-10273
Protein O-mannosylation is a glycan modification that is required for normal nervous system development and function. Mutations in genes involved in protein O-mannosyl glycosylation give rise to a group of neurodevelopmental disorders known as congen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::485de17f1d3a85a648495fcc77571c3d
https://doi.org/10.1074/jbc.m114.614099
https://doi.org/10.1074/jbc.m114.614099