Zobrazeno 1 - 10
of 256
pro vyhledávání: '"Chrishan S. Samuel"'
Autor:
Amlan Chakraborty, Chao Wang, Margeaux Hodgson-Garms, Brad R.S. Broughton, Jessica E. Frith, Kilian Kelly, Chrishan S. Samuel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 178, Iss , Pp 117259- (2024)
Idiopathic pulmonary fibrosis (IPF) is characterised by lung scarring and stiffening, for which there is no effective cure. Based on the immunomodulatory and anti-fibrotic effects of induced pluripotent stem cell (iPSC) and mesenchymoangioblast-deriv
Externí odkaz:
https://doaj.org/article/6363c9c052c0413480e5c6e789921b3d
Autor:
Tara E. Scott, Caitlin V. Lewis, Mingyu Zhu, Chao Wang, Chrishan S. Samuel, Grant R. Drummond, Barbara K. Kemp-Harper
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract In cardiovascular disease, pathological and protective roles are reported for the Th2 cytokines IL-4 and IL-13, respectively. We hypothesised that differential effects on macrophage function are responsible. Type I and II receptor subunit (I
Externí odkaz:
https://doaj.org/article/2a6a6a71d4aa43fea91cce8e51b240f8
Autor:
Amlan Chakraborty, Keshav Raj Paudel, Chao Wang, Gabriele De Rubis, Dinesh Kumar Chellappan, Philip Michael Hansbro, Chrishan S. Samuel, Kamal Dua
Publikováno v:
EXCLI Journal : Experimental and Clinical Sciences, Vol 22, Pp 1104-1108 (2023)
Externí odkaz:
https://doaj.org/article/53c10037cd564641abf92b9bc6c76ce1
Autor:
Mandy Li, Levi Nguyen, Dorota Ferens, Iresha Spizzo, Yan Wang, Kate M. Denton, Mark Del Borgo, Ketav Kulkarni, Marie-Isabel Aguilar, Chengxue Helena Qin, Chrishan S. Samuel, Tracey A. Gaspari, Robert E. Widdop
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115238- (2023)
Stimulation of the angiotensin II type 2 receptor (AT2R) evokes protective effects in various cardiovascular diseases. Thus, this study aimed to investigate the effects of AT2R stimulation, with or without AT1R blockade, in a model of hypertension wi
Externí odkaz:
https://doaj.org/article/b1d834f8402f4ea782bf61b6650ba215
Autor:
Tingfang Zhang, Yifang Li, Andrea F. Wise, Ketav Kulkarni, Marie-Isabel Aguilar, Chrishan S. Samuel, Mark Del Borgo, Robert E. Widdop, Sharon D. Ricardo
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 161, Iss , Pp 114556- (2023)
Background and purpose: This study investigated the reno-protective effects of a highly selective AT2R agonist peptide, β-Pro7Ang III in a mouse model of acute kidney injury (AKI). Methods: C57BL/6 J mice underwent either sham surgery or unilateral
Externí odkaz:
https://doaj.org/article/8f09833c4fcb4a20a16d01c85cdadc4a
Autor:
Fariha Alam, Tracey A. Gaspari, Barbara K. Kemp-Harper, Edward Low, Aaron Aw, Dorota Ferens, Iresha Spizzo, Ann-Maree Jefferis, Praveen Praveen, Robert E. Widdop, Ross A.D. Bathgate, Mohammed Akhter Hossain, Chrishan S. Samuel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 160, Iss , Pp 114370- (2023)
The hormone, relaxin (RLX), exerts various organ-protective effects independently of etiology. However, its complex two-chain and three disulphide bonded structure is a limitation to its preparation and affordability. Hence, a single chain-derivative
Externí odkaz:
https://doaj.org/article/5ab983e3650b46eba55d98f76cfcbf69
Autor:
Yifang Li, Gang Zheng, Ekaterina Salimova, Brad R.S. Broughton, Sharon D. Ricardo, Michael de Veer, Chrishan S. Samuel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114069- (2023)
Fibrosis is a hallmark of chronic hypertension and disrupts the viability of human bone marrow-derived mesenchymal stromal cells (BM-MSCs) post-transplantation. This study thus, determined whether the anti-fibrotic drug, serelaxin (RLX), could enhanc
Externí odkaz:
https://doaj.org/article/75a07e6e4dd34ed5af3fea4c13cc0caa
Autor:
Udari Eshani Perera, Louise Organ, Simon G. Royce, Chrishan S. Samuel, Habtamu B. Derseh, Sasika N. V. Dewage, Emmanuel Koumoundouros, Andrew Stent, Kenneth J. Snibson
Publikováno v:
Canadian Respiratory Journal, Vol 2023 (2023)
Idiopathic pulmonary fibrosis (IPF) is a chronic disease characterized by excessive deposition of extracellular matrix in the interstitial lung parenchyma, often manifested by dyspnea and progressive loss of lung function. The role of inflammation in
Externí odkaz:
https://doaj.org/article/c4cdbb816e0647ad8668c4493bf7d4c0
Autor:
Praveen Praveen, Chao Wang, Thomas N. G. Handley, Hongkang Wu, Chrishan S. Samuel, Ross A. D. Bathgate, Mohammed Akhter Hossain
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6616 (2023)
Human relaxin-2 (H2 relaxin) is therapeutically very important due to its strong anti-fibrotic, vasodilatory, and cardioprotective effects. Therefore, relaxin’s receptor, relaxin family peptide receptor 1 (RXFP1), is a potential target for the trea
Externí odkaz:
https://doaj.org/article/45351c93f2a044ac83108d99b7449121
Autor:
Yifang Li, Amlan Chakraborty, Brad R.S. Broughton, Dorota Ferens, Robert E. Widdop, Sharon D. Ricardo, Chrishan S. Samuel
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112256- (2021)
Fibrosis, a hallmark of chronic kidney disease (CKD), impairs the viability of human bone marrow derived-mesenchymal stromal cells (BM-MSCs) post-transplantation. To address this, we demonstrated that combining BM-MSCs with the anti-fibrotic drug, se
Externí odkaz:
https://doaj.org/article/b54d14cd5a744650955a465e368c1bac