Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Chris-Anne McKenzie"'
Autor:
Raphael Hesse, Maica Llavero Hurtado, Rosemary J. Jackson, Samantha L. Eaton, Abigail G. Herrmann, Marti Colom-Cadena, Makis Tzioras, Declan King, Jamie Rose, Jane Tulloch, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Douglas Lamont, Thomas M. Wishart, Tara L. Spires-Jones
Publikováno v:
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Abstract Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently observed that the strongest genetic risk factor for sporadic AD, ap
Externí odkaz:
https://doaj.org/article/ad825fe296684195b97f38283374885a
Autor:
Eleanor K. Pickett, Abigail G. Herrmann, Jamie McQueen, Kimberly Abt, Owen Dando, Jane Tulloch, Pooja Jain, Sophie Dunnett, Sadaf Sohrabi, Maria P. Fjeldstad, Will Calkin, Leo Murison, Rosemary J. Jackson, Makis Tzioras, Anna Stevenson, Marie d’Orange, Monique Hooley, Caitlin Davies, Marti Colom-Cadena, Alejandro Anton-Fernandez, Declan King, Iris Oren, Jamie Rose, Chris-Anne McKenzie, Elizabeth Allison, Colin Smith, Oliver Hardt, Christopher M. Henstridge, Giles E. Hardingham, Tara L. Spires-Jones
Publikováno v:
Cell Reports, Vol 29, Iss 11, Pp 3592-3604.e5 (2019)
Summary: A key knowledge gap blocking development of effective therapeutics for Alzheimer’s disease (AD) is the lack of understanding of how amyloid beta (Aβ) peptide and pathological forms of the tau protein cooperate in causing disease phenotype
Externí odkaz:
https://doaj.org/article/5c607706c23f4f7d92a682e925ca0372
Microbes in human brain and their potential contribution to neurodegenerative conditions such as Alzheimer’s disease (AD) have long been debated. We recently developed a new method (the electronic tree of life, eToL) based on small subunit ribosoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4e0f8b309474fec70beb113521598079
https://doi.org/10.1101/2023.02.06.527297
https://doi.org/10.1101/2023.02.06.527297
Autor:
Hebah Ali, Olusola Jumoke Daramola, Colin Smith, Chris-Anne McKenzie, Tom Solomon, Laura A Benjamin
Publikováno v:
Daramola, O, Ali, H, Mckenzie, C, Smith, C, Benjamin, L A & Solomon, T 2021, ' Pre-clinical atherosclerosis is found at post-mortem, in the brains of men with HIV ', Journal of NeuroVirology, vol. 27 . https://doi.org/10.1007/s13365-020-00917-1
Journal of Neurovirology
Journal of Neurovirology
The aim of this study is to ascertain the burden of pre-clinical atherosclerotic changes in the brains of young adult males with HIV and explore the impact of anti-retroviral therapy (ART). The study design is case-control, cross-sectional. Histologi
Autor:
Marc R. Dweck, Agne Stadulyte, Christophe Lucatelli, Ralph Bouhaidar, Adriana Tavares, Gillian A. Gray, Mark G. MacAskill, William Mungall, Carlos J. Alcaide-Corral, Nick Spath, Nikki L. Sloan, David E. Newby, Sally L. Pimlott, Andrew Sutherland, Catriona Wimberley, Tashfeen Walton, Lewis Williams, Chris-Anne McKenzie, Timaeus E. F. Morgan
Publikováno v:
Macaskill, M, Stadulyte, A, Williams, L, Morgan, T E F, Sloan, N L, Corral, C A, Walton, T, Wimberley, C, McKenzie, C-A, Spath, N, Mungall, W, Bouhaidar, R, Dweck, M R, Gray, G, Newby, D E, Lucatelli, C, Sutherland, A, Pimlott, S & Tavares, A A S 2020, ' Quantification of macrophage-driven inflammation during myocardial infarction with 18F-LW223, a novel TSPO radiotracer with binding independent of the rs6971 human polymorphism ', Journal of Nuclear Medicine . https://doi.org/10.2967/jnumed.120.243600
Journal of Nuclear Medicine
Journal of Nuclear Medicine
Visual Abstract
Myocardial infarction (MI) is one of the leading causes of death worldwide, and inflammation is central to tissue response and patient outcomes. The 18-kDa translocator protein (TSPO) has been used in PET as an inflammatory bioma
Myocardial infarction (MI) is one of the leading causes of death worldwide, and inflammation is central to tissue response and patient outcomes. The 18-kDa translocator protein (TSPO) has been used in PET as an inflammatory bioma
Autor:
Chris-Anne McKenzie, Keith M. Channon, Colin Smith, Lampson M. Fan, Gavin Brooks, Sarah Cahill-Smith, Fangfei Liu, Li Geng, Gillian Douglas, Jian-Mei Li
Publikováno v:
Fan, L M, Geng, L, Cahill-smith, S, Liu, F, Douglas, G, Mckenzie, C, Smith, C, Brooks, G, Channon, K M & Li, J 2019, ' Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature ', Journal of Clinical Investigation . https://doi.org/10.1172/JCI125173
The Journal of Clinical Investigation
The Journal of Clinical Investigation
Oxidative stress plays an important role in aging-related neurodegeneration. This study used littermates of WT and Nox2-knockout (Nox2KO) mice plus endothelial cell–specific human Nox2 overexpression–transgenic (HuNox2Tg) mice to investigate Nox2
Autor:
Christopher M. Henstridge, Raphael Hesse, Douglas J. Lamont, Martí Colom-Cadena, Jane Tulloch, Jamie Rose, Samantha L. Eaton, Tara L. Spires-Jones, Chris-Anne McKenzie, Abigail G. Herrmann, Thomas M. Wishart, Makis Tzioras, Declan King, Colin Smith, Rosemary J. Jackson, Maica Llavero Hurtado
Publikováno v:
Acta Neuropathologica Communications
Hesse, R, Llavero Hurtado, M, Jackson, R J, Eaton, S L, Herrmann, A G, Colom-Cadena, M, Tzioras, M, King, D, Rose, J, Tulloch, J, McKenzie, C-A, Smith, C, Henstridge, C M, Lamont, D, Wishart, T M & Spires-Jones, T L 2019, ' Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype ', Acta Neuropathologica Communications, vol. 7, 214 . https://doi.org/10.1186/s40478-019-0847-7
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Hesse, R, Llavero Hurtado, M, Jackson, R J, Eaton, S L, Herrmann, A G, Colom-Cadena, M, Tzioras, M, King, D, Rose, J, Tulloch, J, McKenzie, C-A, Smith, C, Henstridge, C M, Lamont, D, Wishart, T M & Spires-Jones, T L 2019, ' Comparative profiling of the synaptic proteome from Alzheimer’s disease patients with focus on the APOE genotype ', Acta Neuropathologica Communications, vol. 7, 214 . https://doi.org/10.1186/s40478-019-0847-7
Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-18 (2019)
Degeneration of synapses in Alzheimer’s disease (AD) strongly correlates with cognitive decline, and synaptic pathology contributes to disease pathophysiology. We recently discovered that the strongest genetic risk factor for sporadic AD, apolipopr
Autor:
Sanziana Rotariu, Thomas H. Gillingwater, Judith Newton, Siddharthan Chandran, Colin Smith, Elaine M. Cleary, Christine A. F. von Arnim, Danielle Leighton, Jon Warner, Tara L. Spires-Jones, Dimitrios I Sideris, Makis Tzioras, Dorothée Lulé, Robert Swingler, Chris-Anne McKenzie, Albert C. Ludolph, Emily Carroll, Sharon Abrahams, Sally Salomonsson, Christopher M. Henstridge
Publikováno v:
Henstridge, C M, Sideris, D I, Carroll, E, Rotariu, S, Salomonsson, S, Tzioras, M, McKenzie, C-A, Smith, C, von Arnim, C A F, Ludolph, A C, Lulé, D, Leighton, D, Warner, J, Cleary, E, Newton, J, Swingler, R, Chandran, S, Gillingwater, T H, Abrahams, S & Spires-Jones, T L 2018, ' Synapse loss in the prefrontal cortex is associated with cognitive decline in amyotrophic lateral sclerosis ', Acta Neuropathologica, vol. 135, no. 2, pp. 213-226 . https://doi.org/10.1007/s00401-017-1797-4
Acta Neuropathologica
Acta Neuropathologica
In addition to motor neurone degeneration, up to 50% of amyotrophic lateral sclerosis (ALS) patients present with cognitive decline. Understanding the neurobiological changes underlying these cognitive deficits is critical, as cognitively impaired pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84638ff2b8aaa1b3d1c9e77fdd16a679
https://www.pure.ed.ac.uk/ws/files/50603954/10.1007_2Fs00401_017_1797_4.pdf
https://www.pure.ed.ac.uk/ws/files/50603954/10.1007_2Fs00401_017_1797_4.pdf
Autor:
Ian J. Deary, Makis Tzioras, Tara L. Spires-Jones, Chris-Anne McKenzie, Colin Smith, Christopher M. Henstridge, Jacqueline Easter, Sarah E. Harris
Publikováno v:
Tzioras, M, Easter, J, Harris, S, McKenzie, C-A, Smith, C, Deary, I, Henstridge, C & Spires-Jones, T 2017, ' Assessing amyloid-β, tau, and glial features in Lothian Birth Cohort 1936 participants post-mortem ', Science Matters, pp. 1-8 . https://doi.org/10.19185/matters.201708000003
Decline in cognitive function is one of the most feared aspects of ageing. We are yet to fully understand why some people age with relatively intact cognition, while others experience subtle cognitive decline or even dementia. The Lothian Birth Cohor
Autor:
Wei Wei, Michael J. Keogh, Ian Wilson, Jonathan Coxhead, Sarah Ryan, Sara Rollinson, Helen Griffin, Marzena Kurzawa-Akanbi, Mauro Santibanez-Koref, Kevin Talbot, Martin R. Turner, Chris-Anne McKenzie, Claire Troakes, Johannes Attems, Colin Smith, Safa Al Sarraj, Christopher M. Morris, Olaf Ansorge, Stuart Pickering-Brown, James W. Ironside, Patrick F Chinnery
Publikováno v:
Acta Neuropathologica Communications