Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Chris Tikellis"'
Autor:
Nordin M.J. Hanssen, Chris Tikellis, Raelene J. Pickering, Dragana Dragoljevic, Man Kit Sam Lee, Tomasz Block, Jean LJM Scheijen, Kristiaan Wouters, Toshio Miyata, Mark E. Cooper, Andrew J. Murphy, Merlin C. Thomas, Casper G. Schalkwijk
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 158, Iss , Pp 114211- (2023)
Methylglyoxal (MGO) is a reactive glucose metabolite linked to diabetic cardiovascular disease (CVD). MGO levels surge during intermittent hyperglycemia. We hypothesize that these MGO spikes contribute to atherosclerosis, and that pyridoxamine as a M
Externí odkaz:
https://doaj.org/article/780490df861446fbb2b17dfaf51ca12a
Autor:
Chris Tikellis, Gardner N. Robinson, Carlos J. Rosado, Duygu Batu, Maria A. Zuniga-Gutierrez, Raelene J. Pickering, Merlin C. Thomas
Publikováno v:
Antioxidants, Vol 11, Iss 5, p 987 (2022)
Circulating levels of soluble ACE2 are increased by diabetes. Although this increase is associated with the presence and severity of cardiovascular disease, the specific role of soluble ACE2 in atherogenesis is unclear. Previous studies suggested tha
Externí odkaz:
https://doaj.org/article/8055f66bf6ed4d62bf58da6cb400a7df
Autor:
Mayur Garg, Simon G. Royce, Chris Tikellis, Claire Shallue, Pavel Sluka, Hady Wardan, Patrick Hosking, Shaun Monagle, Merlin Thomas, John S. Lubel, Peter R. Gibson
Publikováno v:
Therapeutic Advances in Gastroenterology, Vol 12 (2019)
Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD). Methods: Colonoscopic biopsies and intestinal resection specimens from the terminal ileum, ascending and sigmoid colon
Externí odkaz:
https://doaj.org/article/0ab7f334e29d48daa8b1a4d4596715cd
Autor:
Elena Velkoska, Sheila K Patel, Karen Griggs, Raelene J Pickering, Chris Tikellis, Louise M Burrell
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0118758 (2015)
Angiotensin converting enzyme (ACE) 2 is an important modulator of the renin angiotensin system (RAS) through its role to degrade angiotensin (Ang) II. Depletion of kidney ACE2 occurs following kidney injury due to renal mass reduction and may contri
Externí odkaz:
https://doaj.org/article/0e7c4fc16b594813b464992358de9720
Publikováno v:
Journal of Hypertension. 39:e341-e342
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc4337ae7d8e8260bf598f8b44e4944b
https://doi.org/10.1097/01.hjh.0000748476.77597.de
https://doi.org/10.1097/01.hjh.0000748476.77597.de
Autor:
Eoin P. Brennan, Monica de Gaetano, Raelene Pickering, Sinda Derouiche, Bo Wang, Patrick J. Guiry, Muthukumar Mohan, Phillip Kantharidis, Catherine Godson, Stephen P. Gray, Karin Jandeleit-Dahm, Orina Belton, Mark E. Cooper, Ophelie Beuscart, Chris Tikellis, Mary Barry, Mariam Marai, Aaron McClelland, Syed Tasadaque Ali-Shah
Publikováno v:
Diabetes. 66:2266-2277
The let-7 miRNA family plays a key role in modulating inflammatory responses. Vascular smooth muscle cell (SMC) proliferation and endothelial cell (EC) dysfunction are critical in the pathogenesis of atherosclerosis, including in the setting of diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a65ae42d2f92878d2f29d86ccc6b681b
https://doi.org/10.2337/db16-1405
https://doi.org/10.2337/db16-1405
Autor:
Paul Norman, Susan K. Morton, Corey S. Moran, Chris Tikellis, Louise M Burrell, Merlin C. Thomas, Smriti M. Krishna, Jonathan Golledge, Erik Biros, Yutang Wang, Joseph V. Moxon, Mark E. Cooper
Publikováno v:
Arteriosclerosis, thrombosis, and vascular biology. 37(11)
Objective— Recent evidence suggests an important role for angiotensin-converting enzyme 2 (ACE2) in limiting abdominal aortic aneurysm (AAA). This study examined the effect of ACE2 deficiency on AAA development and the efficacy of resveratrol to up
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98b6d4a95d703e76ff647fa280ffbded
https://pubmed.ncbi.nlm.nih.gov/28935757
https://pubmed.ncbi.nlm.nih.gov/28935757
Autor:
Karin Jandeleit-Dahm, Chris Tikellis, Raelene Pickering, Mark E. Cooper, Merlin C. Thomas, Olivier Huet, Despina Tsorotes
Publikováno v:
Diabetes. 63:3915-3925
The deleterious effects of high glucose levels and enhanced metabolic flux on the vasculature are thought to be mediated by the generation of toxic metabolites, including reactive dicarbonyls like methylglyoxal (MG). In this article, we demonstrate t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23e03b43bef2f3432aead56f0841db16
https://doi.org/10.2337/db13-0932
https://doi.org/10.2337/db13-0932
Publikováno v:
American Journal of Physiology-Renal Physiology. 306:F773-F780
The degradation of ANG II by angiotensin-converting enzyme 2 (ACE2), leading to the formation of ANG(1–7), is an important step in the regulation of the renin-angiotensin-aldosterone system (RAAS), and one that is significantly altered in the diabe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb1e9b48a1f88d9cae730c4f2d280b88
https://doi.org/10.1152/ajprenal.00264.2013
https://doi.org/10.1152/ajprenal.00264.2013
Autor:
John S Lubel, Shaun Monagle, Simon G. Royce, Patrick Hosking, Chris Tikellis, Merlin C. Thomas, Hady Wardan, Mayur Garg, Claire Shallue, Peter R. Gibson, Pavel Sluka
Publikováno v:
Therapeutic Advances in Gastroenterology
Therapeutic Advances in Gastroenterology, Vol 12 (2019)
Therapeutic Advances in Gastroenterology, Vol 12 (2019)
Background: The intestinal vitamin D receptor (VDR) remains poorly characterized in patients with inflammatory bowel disease (IBD). Methods: Colonoscopic biopsies and intestinal resection specimens from the terminal ileum, ascending and sigmoid colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00b293bf7f9a235b1815be90823ed8b0
https://doi.org/10.1177/1756284818822566
https://doi.org/10.1177/1756284818822566