Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Chris T. M. Speakman"'
1
The colon-selective spasmolytic otilonium bromide inhibits muscarinic M3receptor-coupled calcium signals in isolated human colonic crypts
Autor: William Stebbings, Shaun Greer, Phillip A. Sharp, Mark Williams, Chris T. M. Speakman, Stefano Evangelista, Michael Lewis, James Hernon, Michael J. C. Rhodes, Ian T. Johnson, S. Addison, R Tighe, Susanne Lindqvist, Jean Mackay, Neil Johns, Mark A. Watson
Publikováno v: British Journal of Pharmacology. 137:1134-1142
1. Otilonium bromide (OB) is a smooth muscle relaxant used in the treatment of irritable bowel syndrome. Otilonium bromide has been shown to interfere with the mobilization of calcium in intestinal smooth muscle, but the effects on other intestinal t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed186785143c1421317ea47afdc2629a
https://doi.org/10.1038/sj.bjp.0704942
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2
Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor
Autor: Chris T. M. Speakman, William S.L. Stebbings, Mark A. Watson, Alexandre Loktionov, Sheila Bingham, Marc J. Gunter
Publikováno v: Carcinogenesis. 22:1053-1060
The distribution of polymorphisms in the glutathione S-transferase (GST) family genes has been studied in 355 healthy controls and 206 cancer (59 proximal and 147 distal) patients. All controls were subjected to flexible sigmoidoscopy. Odds ratios (O
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7209a06a600ecb9ca28923e205397ed9
https://doi.org/10.1093/carcin/22.7.1053
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3
Apolipoprotein E gene polymorphism and colorectal cancer: gender-specific modulation of risk and prognosis
Autor: Mark A. WATSON, Laura GAY, William S. L. STEBBINGS, Chris T. M. SPEAKMAN, Sheila A. BINGHAM, Alexandre LOKTIONOV
Publikováno v: Clinical science (London, England : 1979). 104(5)
Apolipoprotein E ( ApoE ) gene polymorphism is a major factor in lipid metabolism. It has been suggested that this polymorphism can modulate colorectal tumour risk. We tested this hypothesis for colorectal cancer (CRC). ApoE genotype was determined i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ccd8ee12ebb2f835ad1bda3dadfd6ac
https://pubmed.ncbi.nlm.nih.gov/12529167
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4
Plasminogen activator inhibitor-1 gene polymorphism and colorectal cancer risk and prognosis
Autor: Chris T. M. Speakman, Sheila Bingham, William Stebbings, Alexandre Loktionov, Mark A. Watson
Publikováno v: Cancer letters. 189(2)
Plasminogen activator inhibitor-1 (PAI-1) is a factor in urokinase-type plasminogen activator proteolytic system, which is important for tumour invasion and metastasis. Elevated PAI-1 levels in tumours are associated with poor prognosis. An insertion
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f4f641883b6ed3e13e249e546b418c
https://pubmed.ncbi.nlm.nih.gov/12490312
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5
K-ras mutations, rectal crypt cells proliferation, and meat consumption in patients with left-sided colorectal carcinoma
Autor: H J Kennedy, William Stebbings, Ian T. Johnson, J. M. Gee, M. Rhodes, J A Matthew, H. O'Brien, Chris T. M. Speakman, Mark Watson
Publikováno v: European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). 9(1)
It has been suggested that N-nitroso compounds derived from meat may increase the risk of K-ras mutations in the human colon. We sought evidence of associations between red meat consumption, frequency and type of K-ras mutations in resected tumours,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db4b42690079dc17697d80626a3c592
https://pubmed.ncbi.nlm.nih.gov/10777009
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