Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Chris Soon Heng TAN"'
Autor:
Siyuan Sun, Zhenxiang Zheng, Jun Wang, Fengming Li, An He, Kunjia Lai, Shuang Zhang, Jia-Hong Lu, Ruijun Tian, Chris Soon Heng Tan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Cellular activities are carried out vastly by protein complexes but large repertoire of protein complexes remains functionally uncharacterized which necessitate new strategies to delineate their roles in various cellular processes and diseas
Externí odkaz:
https://doaj.org/article/c7fd81b0a2864247833b6591421da0f1
Autor:
Qi Zhu, Juxian Song, Jia-Yue Chen, Zhenwei Yuan, Liangfeng Liu, Li-Ming Xie, Qiwen Liao, Richard D. Ye, Xiu Chen, Yepiao Yan, Jieqiong Tan, Chris Soon Heng Tan, Min Li, Jia-Hong Lu
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 6, Pp 2701-2714 (2023)
Parkinson's disease (PD) is the most common neurodegenerative movement disease. It is featured by abnormal alpha-synuclein (α-syn) aggregation in dopaminergic neurons in the substantia nigra. Macroautophagy (autophagy) is an evolutionarily conserved
Externí odkaz:
https://doaj.org/article/f4a392529025494f9c26577ce4358079
Publikováno v:
Chinese Medicine, Vol 17, Iss 1, Pp 1-14 (2022)
Abstract Background Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast cancer that develops resistance to chemotherapy frequently. Autophagy has been reported as a pro-survival response to chemotherapeutic drugs in TNBC, an
Externí odkaz:
https://doaj.org/article/c3f86beebc584ef0a9b7452a26b3cff2
Autor:
Yan Ting Lim, Nayana Prabhu, Lingyun Dai, Ka Diam Go, Dan Chen, Lekshmy Sreekumar, Louise Egeblad, Staffan Eriksson, Liyan Chen, Saranya Veerappan, Hsiang Ling Teo, Chris Soon Heng Tan, Johan Lengqvist, Andreas Larsson, Radoslaw M Sobota, Pär Nordlund
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0208273 (2018)
Metabolite-protein interactions define the output of metabolic pathways and regulate many cellular processes. Although diseases are often characterized by distortions in metabolic processes, efficient means to discover and study such interactions dir
Externí odkaz:
https://doaj.org/article/dcb759615b25496c939a0c9fb00a7898
Vast majority of cellular activities are carried out by protein complexes that assembled dynamically in response to cellular needs and environmental cues. Large scale efforts had uncovered a large repertoire of functionally uncharacterized protein co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c75454c63e48e408c3bae93ddb4fab21
https://doi.org/10.1101/2023.02.13.528386
https://doi.org/10.1101/2023.02.13.528386
Autor:
Sebastian Maurer-Stroh, Ashar Malik, Dimitar Kenanov, Cheng-Shoong Chong, Mert Burak Ozturk, Maxime Hebrard, Ying Swan Ho, Zhenxun Wang, Vachiranee Limviphuvadh, Jhoann Miyajima, Roberto Magallanes, Xueling Sim, Jin Fang Chai, Sonia Davila, Khung Keong Yeo, Khai Pang Leong, Liuh Ling Goh, Neerja Karnani, Johan Gunnar Eriksson, Ching-Yu Cheng, Tien Wong, Marie Loh, Rinkoo Dalan, Chiea Chuen Khor, Guo-Liang Chew, Weng Khong Lim, Joanne Ngeow, John Chambers, E Shyong Tai, Nicolas Bertin, Chris Soon Heng Tan, Judice Koh, Patrick Tan, Chandra Verma
One of the promises of precision medicine is to understand and act on inter-individual genetic differences in drug responses. SNPdrug3D contains the complete genomic landscape of missense single nucleotide variants (SNV) across the human proteome and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dea066a53ae7a448d8ac2483b836a175
https://doi.org/10.21203/rs.3.rs-2377190/v1
https://doi.org/10.21203/rs.3.rs-2377190/v1
Autor:
Er-jin Wang, Ming-Yue Wu, Zheng-yu Ren, Ying Zheng, Richard D Ye, Chris Soon Heng TAN, Yitao Wang, Jia-Hong Lu
Publikováno v:
Burns & Trauma. 11
Inflammatory bowel disease (IBD) is a chronic, non-specific, recurrent inflammatory disease, majorly affecting the gastrointestinal tract. Due to its unclear pathogenesis, the current therapeutic strategy for IBD is focused on symptoms alleviation. A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d4c29ac6dc0e896cecb71e52b25fa8e
https://doi.org/10.1093/burnst/tkad004
https://doi.org/10.1093/burnst/tkad004
Autor:
Yuh Fen Pung, Saiful Effendi Syafruddin, Adaikkalam Vellaichamy, M. Aiman Mohtar, Nisa Syakila A Rahman, Teck Yew Low, Chris Soon Heng Tan
Publikováno v:
Cellular and Molecular Life Sciences
Protein-protein interactions are fundamental to various aspects of cell biology with many protein complexes participating in numerous fundamental biological processes such as transcription, translation and cell cycle. MS-based proteomics techniques a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a293c4a875a79c687c72a73a0145059
http://europepmc.org/articles/PMC8159249
http://europepmc.org/articles/PMC8159249
Publikováno v:
Computers in Biology and Medicine. 159:106936
Detecting protein complexes is critical for studying cellular organizations and functions. The accumulation of protein-protein interaction (PPI) data enables the identification of protein complexes computationally. Although various computational appr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67ba64b6e918365cf15d8bd18a788487
https://doi.org/10.1016/j.compbiomed.2023.106936
https://doi.org/10.1016/j.compbiomed.2023.106936
Publikováno v:
Briefings in Bioinformatics. 23
The Cellular Thermal Shift Assay (CETSA) plays an important role in drug-target identification, and statistical analysis is a crucial step significantly affecting conclusion. We put forward ProSAP (Protein Stability Analysis Pod), an open-source, cro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca13bbb1e261072c7d5c0fde4987c647
https://doi.org/10.1093/bib/bbac057
https://doi.org/10.1093/bib/bbac057