Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chris Silvin"'
Autor:
James Hodge, Jay Friedman, Michelle R Padget, Yvette Robbins, Maxwell Y Lee, Cem Sievers, Paul E Clavijo, Nancy Judd, Edward Tsong, Chris Silvin, Christian Hinrichs, Clint Allen
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background As heterogeneous tumors develop in the face of intact immunity, tumor cells harboring genomic or expression defects that favor evasion from T-cell detection or elimination are selected. For patients with such tumors, T cell-based immunothe
Externí odkaz:
https://doaj.org/article/c6d86720da2e4d9396554cd7aa78e226
Autor:
Clint Allen, Carter Van Waes, Chris Silvin, Zhong Chen, Harrison Cash, Jay Friedman, Paul E. Clavijo, Ellen C. Moore, Ruth J. Davis
The supplemental figures demonstrate data supportive of the overall conclusions of this manuscript including MDSC flow cytometry gating strategy, evidence for moderate suppression of peripheral MDSC T-lymphocyte suppressive capacity after IPI-145 mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be2d62a9996ce9a40d930f82060185e
https://doi.org/10.1158/0008-5472.22413357.v1
https://doi.org/10.1158/0008-5472.22413357.v1
Autor:
Clint Allen, Carter Van Waes, Chris Silvin, Zhong Chen, Harrison Cash, Jay Friedman, Paul E. Clavijo, Ellen C. Moore, Ruth J. Davis
Checkpoint inhibitors are relatively inefficacious in head and neck cancers, despite an abundance of genetic alterations and a T-cell–inflamed phenotype. One significant barrier to efficacy may be the recruitment of myeloid-derived suppressor cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d258e30e44a79aec8e3c9cdc9d8a8ba
https://doi.org/10.1158/0008-5472.c.6508692.v1
https://doi.org/10.1158/0008-5472.c.6508692.v1
Autor:
Rita Das, John A. Zebala, Jeffrey Schlom, Lucas A. Horn, Claudia Palena, Clint T. Allen, Yvette Robbins, Chris Silvin, Sarah Greene, Jay Friedman, Priya Patel, Lillian Sun, Carter Van Waes, Dean Y. Maeda, Paul E. Clavijo
Publikováno v:
JCI Insight. 4
Recruitment of myeloid-derived suppressor cells (MDSCs) into tumors induces local immunosuppression in carcinomas. Here, we assessed whether SX-682, an orally bioavailable small-molecule inhibitor of CXCR1 and CXCR2, could block tumor MDSC recruitmen
Autor:
Maxwell Y Lee, Paul E. Clavijo, Chris Silvin, Patrick Soon-Shiong, Jeffrey Schlom, Michelle R Padget, Edward Tsong, James W. Hodge, Cem Sievers, Clint T. Allen, Jay Friedman, Houssein Abdul Sater, Christian S. Hinrichs, Nancy P. Judd, Yvette Robbins
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundAs heterogeneous tumors develop in the face of intact immunity, tumor cells harboring genomic or expression defects that favor evasion from T-cell detection or elimination are selected. For patients with such tumors, T cell-based immunother
Autor:
Jun Jeon, Xinping Yang, Carter Van Waes, Scott E. Martin, Pinar Ormanoglu, Shaleeka Cornelius, Hui Cheng, Anthony Saleh, Zhong Chen, Chris Silvin, Sophie Carlson
Publikováno v:
Cancer Research. 80:605-605
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide with five-year overall survival rate of about 50%. Analysis of The Cancer Genome Atlas (TCGA) dataset showed that one or more molecules linked to the tumor necros
Autor:
Ellen C. Moore, Chris Silvin, Ruth J. Davis, Clint T. Allen, Paul E. Clavijo, Zhong Chen, Carter Van Waes
Publikováno v:
Cancer Research. 76:1477-1477
BACKGROUND: IPI-145 (duvelisib) is an oral inhibitor of the p110δ/γ isoforms of phosphinositide 3-kinase (PI3K) that are differentially expressed in leukocytes. IPI-145 is currently under study in phase II/III trials for the treatment of hematologi
Publikováno v:
Advances in experimental medicine and biology. 723
Publikováno v:
Retinal Degenerative Diseases ISBN: 9781461406303
Choroideremia (CHM) is an X-linked form of retinal degeneration, caused by loss of function mutations in the CHM gene that encodes Rab Escort Protein 1 gene (REP1). REP1 is a key regulator of vesicular trafficking, phagosome fusion, and maturation. W
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b42a24b7495bc4076fe9e9987dd23acf
https://doi.org/10.1007/978-1-4614-0631-0_49
https://doi.org/10.1007/978-1-4614-0631-0_49