Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Chris Siebel"'
1
Fibrosis and Immune Cell Infiltration Are Separate Events Regulated by Cell-Specific Receptor Notch3 Expression
Autor: Chris Siebel, Delia Salaru, Tobias M. Ballhause, Lars Philipsen, Mahmoud M. Ibrahim, Anja Bernhardt, Robert Geffers, Sabine Brandt, Yan Fu, Hien Minh Le-Deffge, Annika Becker, Peter R. Mertens, Jonathan A. Lindquist, Sonja Djudjaj, Berend Isermann, Rafael Kramann, Andreas Müller, Florian H. Heidel, Alexander Fehr
Publikováno v: Journal of the American Society of Nephrology, 31(11), 2589-2608. American Society of Nephrology
Journal of the American Society of Nephrology : JASN
United States
Journal of the American Society of Nephrology
J Am Soc Nephrol
Background Kidney injuries that result in chronic inflammation initiate crosstalk between stressed resident cells and infiltrating immune cells. In animal models, whole-body receptor Notch3 deficiency protects from leukocyte infiltration and organ fi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aa0f51fc596a3d67b2881eed9afd1d0
https://doi.org/10.1681/asn.2019121289
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3
Notch Signaling in Development, Tissue Homeostasis, and Disease
Autor: Chris Siebel, Urban Lendahl
Publikováno v: Physiological Reviews. 97:1235-1294
Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs via cell-cell communication, where transmembrane ligands on one cell
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af500a95ee907c2e57fb4ebc754623af
https://doi.org/10.1152/physrev.00005.2017
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4
Stromal Notch Ligands Drive Notch2-Dependent Transdifferentiation of Follicular B Cells into Marginal Zone-like B Cells in Lymphopenic Environments
Autor: Eric Perkey, Jennifer Londregan, Warren S. Pear, Daniela Gómez Atria, Chris Siebel, Russell J.H. Ryan, Samantha Kelly, Burkhard Ludewig, Brian T. Gaudette, Ivan Maillard, David Allman
Publikováno v: Blood. 136:38-39
In lymphopenic environments, secondary lymphoid organs regulate the size of B and T cell compartments by supporting homeostatic proliferation of mature lymphocytes. Although this process operates in multiple clinically relevant settings, including af
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c7d708a820bbc8acc3f78b0712ee5da
https://doi.org/10.1182/blood-2020-142474
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5
Modulation of Notch1 signaling regulates bone fracture healing
Autor: Kurt D. Hankenson, Brya G. Matthews, Sanja Novak, Emilie Roeder, Douglas J. Adams, Benjamin P. Sinder, Danka Grčević, Chris Siebel, Ivo Kalajzic
Publikováno v: J Orthop Res
Fracture healing involves interactions of different cell types, driven by various growth factors, and signaling cascades. Periosteal mesenchymal progenitor cells give rise to the majority of osteoblasts and chondrocytes in a fracture callus. Notch si
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f03afb25338114848f9df657279b234
https://pubmed.ncbi.nlm.nih.gov/32141629
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Plný text Recenzováno Digitální knihovna AV ČR
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