Výsledky vyhledávání - "Chris Schindler"

Regulation of IFN‐α/β genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN‐α/β

Autor: Tomohiro Takasugi, Chris Schindler, Yasuo Kashiwazaki, Shigeru Noguchi, Mitsuharu Sato, Tadatsugu Taniguchi, Tohru Kimura, Masahito Matsumoto, Motoo Kitagawa, Robert D. Schreiber, Hisashi Harada, Rosemary Sok-Pin Tan, Yuzo Kadokawa, Taeko Yokochi

Publikováno v: Genes to Cells. 1:995-1005

Background: Efficient production of interferons (IFNs) in virally infected cells is an essential aspect of the host defence. The transcription factor complex ISGF3 (IFN-stimulated gene factor 3) was originally identified as a critical mediator of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f57f8dd502b9025dff8e48015cae8d3
https://doi.org/10.1046/j.1365-2443.1996.870287.x

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Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein

Autor: J. T. E. Lim, Hai Yan, Kartik Krishnan, Sanjay Gupta, R. D. Schreiber, John J. Krolewski, Chris Schindler, A. C. Greenlund

Publikováno v: The EMBO Journal. 15:1064-1074

Interferon-alpha (IFN alpha) induces rapid tyrosine phosphorylation of its receptors, two JAK kinases and three STAT transcription factors. One kinase, p135tyk2, is complexed with the IFNaR1 receptor, and may catalyze some of these phosphorylation ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::070fe61a76101b1e15330bf9196c7836
https://doi.org/10.1002/j.1460-2075.1996.tb00444.x

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Distribution of the Mammalian Stat Gene Family in Mouse Chromosomes

Autor: James E. Darnell, Alice L.-F. Mui, Chris Schindler, Zhong Zhong, Atsushi Miyajima, Zilong Wen, Neal G. Copeland, Nancy A. Jenkins, James N. Ihle, Frederick W. Quelle, Debra J. Gilbert

Publikováno v: Genomics. 29:225-228

Studies of transcriptional activation by interferons and a variety of cytokines have led to the identification of a family of proteins that serve as signal transducers and activators of transcription, Stats. Here, we report that the seven mouse Stat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5315a01ed1ed0806f3109dace505ecf8
https://doi.org/10.1006/geno.1995.1235

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Differentiation-Regulated Serine Phosphorylation of STAT1 Promotes GAF Activation in Macrophages

Autor: Andrew F. Wilks, Ailsa G. Harpur, Chris Schindler, D Georgellis, Thomas Decker, A Eilers, Andrew Ziemiecki, B. Klose

Publikováno v: Scopus-Elsevier

Gamma interferon (IFN-gamma), a macrophage-activating cytokine, modulates gene expression through the activity of a transcription factor designated IFN-gamma activation factor (GAF). GAF is formed after phosphorylation on tyrosine and dimerization of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9146cb34d88cc76b646cc1965ba91187
https://doi.org/10.1128/mcb.15.7.3579

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γ Chain-associated Cytokine Receptors Signal through Distinct Transducing Factors

Autor: James Yopp, Evan Garfein, Sanjay Gupta, Chris Schindler, Helena Kashleva, Alessandra B. Pernis, Paul B. Rothman

Publikováno v: Journal of Biological Chemistry. 270:14517-14522

The IL-2, IL-4, and IL-7 signaling pathways have been shown to utilize shared components. The receptors for these cytokines are composed of ligand-specific binding chains that associate with a shared signaling subunit, the common gamma (gamma c) chai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ef4a94dd5e26401a08a0c1a55178e8
https://doi.org/10.1074/jbc.270.24.14517

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Interleukin-6-induced serine phosphorylation of transcription factor APRF: evidence for a role in interleukin-6 target gene induction

Autor: Friedemann Horn, Claudia Schwartz, Eric Caldenhoven, Juping Yuan, Peter C. Heinrich, Paul J. Coffer, Chris Schindler, Claudia Lütticken, Wiebe Kruijer

Publikováno v: FEBS Letters, 360(2), 137-143. Wiley

The cytokine interleukin-6 (IL-6) rapidly activates a latent cytoplasmic transcription factor, acute-phase response factor (APRF), by tyrosine phosphorylation. Activation and DNA binding of APRF are inhibited by inhibitors of protein tyrosine kinases

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f10d0621cb63998844e25cabd8c8d250
https://doi.org/10.1016/0014-5793(95)00076-l

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Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein

Autor: Ian M. Kerr, Teresa Improta, George Stark Stark, Curt M. Horvath, Chris Schindler, James E. Darnell

Publikováno v: Proceedings of the National Academy of Sciences. 91:4776-4780

Transcription factor ISGF-3 is a multiprotein, interferon alpha-activated transcription complex consisting of a 48-kDa DNA-binding protein and two proteins termed Stats (for signal transducers and activators of transcription) that become phosphorylat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bb87676957217aba3a6bcd4388c4a91
https://doi.org/10.1073/pnas.91.11.4776

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A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene

Autor: B. Klose, Chris Schindler, Thomas Decker, I Strehlow, David E. Levy, D Seegert

Publikováno v: Journal of Biological Chemistry. 269:8590-8595

We have investigated the transcriptional response of the IFP53/tryptophanyl-tRNA synthetase gene to interferon-alpha (IFN-alpha). A single gamma-interferon activation site (GAS) in proximity to the transcription start sites was found to mediate the r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::401ac651873f4ca52e67b8f8b4a0782f
https://doi.org/10.1016/s0021-9258(17)37235-6

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A factor induced by differentiation signals in cells of the macrophage lineage binds to the gamma interferon activation site

Autor: Manuela Baccarini, Friedemann Horn, Thomas Decker, Chris Schindler, R A Hipskind, A Eilers

Publikováno v: Europe PubMed Central

Rapid transcriptional induction of genes in response to gamma interferon (IFN-gamma) is mediated by the IFN-gamma activation site (GAS) and its cognate protein, the IFN-gamma activation factor (GAF). We describe a GAS-associated, differentiation-indu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec882db97beafe443cd41c34788f51e
https://doi.org/10.1128/mcb.14.2.1364

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Association of Transcription Factor APRF and Protein Kinase Jak1 with the Interleukin-6 Signal Transducer gp130

Autor: Andrew Ziemiecki, Giovanna Barbieri, Tetsuya Taga, J. Buschmann, Friedemann Horn, Ailsa G. Harpur, Michael Sendtner, Claudia Lütticken, Chris Schindler, Sandra Pellegrini, Peter C. Heinrich, Andrew F. Wilks, Juping Yuan, Kiyoshi Yasukawa, Tadamitsu Kishimoto, U. M. Wegenka

Publikováno v: Scopus-Elsevier

Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, interleukin-11, and ciliary neurotrophic factor bind to receptor complexes that share the signal transducer gp130. Upon binding, the ligands rapidly activate DNA binding of acute-phase r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ed7db58e723dd7093b04988525357e6
https://doi.org/10.1126/science.8272872

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