Výsledky vyhledávání - "Chris S. LeButt"

Increasing the Potency of an Alhydrogel-Formulated Anthrax Vaccine by Minimizing Antigen-Adjuvant Interactions

Autor: Thomas R. Fuerst, Peter C. Fusco, Ashok Ganesan, Jeremy H. Lakey, Karie J. Hirst, Allan Watkinson, Chris S. LeButt, Kelly J. Fleetwood, Andrei Soliakov

Publikováno v: Clinical and Vaccine Immunology. 20:1659-1668

Aluminum salts are the most widely used vaccine adjuvants, and phosphate is known to modulate antigen-adjuvant interactions. Here we report an unexpected role for phosphate buffer in an anthrax vaccine (SparVax) containing recombinant protective anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b72c49becb2e896fe46f09cc73f9c3ed
https://doi.org/10.1128/cvi.00320-13

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Efficient Analysis of Dose—Time—Response Assays

Autor: Chris S. LeButt, Peter C. Fusco, Karie J. Hirst, Kelly J. Fleetwood, Ann Yellowlees

Publikováno v: BioScience. 63:490-498

Two approaches to the estimation of relative potency for dose—time—response assays are compared: the application of a generalized linear model to the dichotomized responses and survival analysis of the time to response. Survival analysis is widel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61c01cc52238a65fddcca6a75946bc6a
https://doi.org/10.1525/bio.2013.63.6.11

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Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax

Autor: Hans Westra, E. Diane Williamson, Chris S. LeButt, Helen C. Flick-Smith, Han Li, Les Baillie, Alfred J. Mateczun, Conrad P. Quinn, Stanley Goldman, Mark T. Albrecht, Darrell R. Galloway, Herman Groen

Publikováno v: Infection and Immunity, 75(11), 5425-5433. AMER SOC MICROBIOLOGY

The unpredictable nature of bioterrorism and the absence of real-time detection systems have highlighted the need for an efficient postexposure therapy forBacillus anthracisinfection. One approach is passive immunization through the administration of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::718f8fcc3bb576c794d2b5ca1c3252d3
https://research.rug.nl/en/publications/1fb0c810-57d5-4235-83a7-eecc337d3e46

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Immunogenicity of Recombinant Protective Antigen and Efficacy against Aerosol Challenge with Anthrax

Autor: Nicola J. Walker, A. W. Topping, I. Hodgson, Ethel Diane Williamson, J. M. Mott, Han Li, H. E. Jones, Conrad P. Quinn, Jim Estep, M. G. Duchars, Helen C. Flick-Smith, Chris S. LeButt

Publikováno v: Infection and Immunity. 73:5978-5987

Immunization with a recombinant form of the protective antigen (rPA) fromBacillus anthracishas been carried out with rhesus macaques. Rhesus macaques immunized with 25 μg or more ofB. subtilis-expressed rPA bound to alhydrogel had a significantly in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12f7079060edddd8f7982bd0b7eee1f
https://doi.org/10.1128/iai.73.9.5978-5987.2005

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Human Immune Response to a Plague Vaccine Comprising Recombinant F1 and V Antigens

Autor: E. L. Waters, Steven M. Jones, Caroline A. Rowland, Helen C. Flick-Smith, Chris S. LeButt, Julie Miller, P. J. Packer, E. D. Williamson, R. J. Gwyther, M. Irving

Publikováno v: Infection and Immunity. 73:3598-3608

The human immune response to a new recombinant plague vaccine, comprising recombinant F1 (rF1) and rV antigens, has been assessed during a phase 1 safety and immunogenicity trial in healthy volunteers. All the subjects produced specific immunoglobuli

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a99a82d0d377991443da393d5b7845
https://doi.org/10.1128/iai.73.6.3598-3608.2005

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Immunisation against plague by transcutaneous and intradermal application of subunit antigens

Autor: E. D. Williamson, Angie Westwood, Stephen J. Elvin, S Somavarapu, Chris S. LeButt, Jim E. Eyles, H.O. Alpar

Publikováno v: Vaccine. 22(31-32)

We have investigated immunological responses in BALB/c mice following transcutaneous (TC) delivery of fraction 1 (F1) and V subunits from Yersinia pestis in conjunction with an enterotoxin-derived adjuvant (cholera toxin, CT). It was found that two o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6de9cbd2d8373590cbc0d48073bfd9
https://pubmed.ncbi.nlm.nih.gov/15474730

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