Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Chris R. Evelyn"'
Autor:
Richard R. Neubig, Sofia D. Merajver, Jorge A. Iñiguez-Lluhí, Mei Wu, Qin Wang, Susan M. Wade, Chris R. Evelyn
Lysophosphatidic acid receptors stimulate a Gα12/13/RhoA-dependent gene transcription program involving the serum response factor (SRF) and its coactivator and oncogene, megakaryoblastic leukemia 1 (MKL1). Inhibitors of this pathway could serve as u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434ab8fcd3429745e1f9e1aa5ec3c02e
https://doi.org/10.1158/1535-7163.c.6532116.v1
https://doi.org/10.1158/1535-7163.c.6532116.v1
Autor:
Jarek Meller, Fukun Guo, Xun Shang, Ahmad Rayes, Nicolas Nassar, Wei Du, Lei Wang, Wei Liu, Yi Zheng, Xueheng Zhao, Chris R. Evelyn, Qishen Pang, Kenneth D.R. Setchell, Maria Carolina Florian, Hartmut Geiger, Marnie A. Ryan
Publikováno v:
Leukemia. 33:749-761
Mobilization of hematopoietic stem cells (HSCs) from bone marrow (BM) to peripheral blood (PB) by cytokine granulocyte colony-stimulating factor (G-CSF) or the chemical antagonist of CXCR4, AMD3100, is important in the treatment of blood diseases. Du
Publikováno v:
Chemistry & Biology. 21:1618-1628
SummaryRas GTPases regulate intracellular signaling involved in cell proliferation. Elevated Ras signaling activity has been associated with human cancers. Ras activation is catalyzed by guanine nucleotide exchange factors (GEFs), of which SOS1 is a
Autor:
Xun Shang, Fillipo Marchioni, Chris R. Evelyn, Nisha Sipes, Xuan Zhou, William Seibel, Matthew Wortman, Yi Zheng
Publikováno v:
Proceedings of the National Academy of Sciences. 110:3155-3160
The G-protein–mediated Rho guanine nucleotide exchange factor (GEF)–Rho GTPase signaling axis has been implicated in human pathophysiology and is a potential therapeutic target. By virtual screening of chemicals that fit into a surface groove of
Autor:
Andrew J. Haak, Craig N. Johnson, Chris R. Evelyn, Erika M. Lisabeth, Susan M. Wade, Elizabeth R. Lawlor, Richard R. Neubig
Publikováno v:
Microarrays, Vol 5, Iss 2, p 13 (2016)
Microarrays; Volume 5; Issue 2; Pages: 13
Microarrays
Microarrays; Volume 5; Issue 2; Pages: 13
Microarrays
Metastasis is the major cause of cancer deaths and control of gene transcription has emerged as a critical contributing factor. RhoA- and RhoC-induced gene transcription via the actin-regulated transcriptional co-activator megakaryocytic leukemia (MK
Autor:
Mei Wu, Sofia D. Merajver, Qin Wang, Richard R. Neubig, Chris R. Evelyn, Jorge A. Iñiguez-Lluhí, Susan M. Wade
Publikováno v:
Molecular Cancer Therapeutics. 6:2249-2260
Lysophosphatidic acid receptors stimulate a Gα12/13/RhoA-dependent gene transcription program involving the serum response factor (SRF) and its coactivator and oncogene, megakaryoblastic leukemia 1 (MKL1). Inhibitors of this pathway could serve as u
Autor:
Erika Huber, Jarek Meller, Neil P. Shah, Zachary Kincaid, Meenu Kesarwani, Mohammad Azam, Yi Zheng, Chris R. Evelyn, Jacek Biesiada, Mahendra Thapa, Mark Rance
Publikováno v:
Scientific Reports
Emergence of genetic resistance against kinase inhibitors poses a great challenge for durable therapeutic response. Here, we report a novel mechanism of JAK2 kinase inhibition by fedratinib (TG101348) that prevents emergence of genetic resistance. Us
Autor:
Xun Shang, Chris R. Evelyn, Ruben Papoian, Sandra Nelson, Jacek Biesiada, Jaroslaw Meller, Hong Tang, Xin Duan, William L. Seibel, Yi Zheng
The Ras family small GTPases regulate multiple cellular processes, including cell growth, survival, movement, and gene expression, and are intimately involved in cancer pathogenesis. Activation of these small GTPases is catalyzed by a special class o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb66d65dfe9396646350537f5a3df29b
https://europepmc.org/articles/PMC4432303/
https://europepmc.org/articles/PMC4432303/
Autor:
William L. Seibel, Fillipo Marchioni, Stefan Duhr, Moran Jerabek-Willemsen, Xun Shang, Nisha Sipes, Yi Zheng, Matthew D. Wortman, Chris R. Evelyn
SummaryRho GTPases have been implicated in diverse cellular functions and are potential therapeutic targets. By virtual screening, we have identified a Rho-specific inhibitor, Rhosin. Rhosin contains two aromatic rings tethered by a linker, and it bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::676ec4cb1900c7a19e2cab3537955a9d
https://europepmc.org/articles/PMC3383629/
https://europepmc.org/articles/PMC3383629/
Autor:
Shanna J Smith, Matthew D. Wortman, Shan Lu, Chris R. Evelyn, Yi Zheng, Zongqing Tan, Zhongyun Dong, Kelsey Dillehay, Linda H. Malkas, William L. Seibel
Proliferating cell nuclear antigen (PCNA), a potential anticancer target, forms a homotrimer and is required for DNA replication and numerous other cellular processes. The purpose of this study was to identify novel small molecules that modulate PCNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a949402e0ddda6c988913c062c81ce
https://europepmc.org/articles/PMC3362894/
https://europepmc.org/articles/PMC3362894/