Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Chris Quan"'
Autor:
Ryan G. Lim, Chris Quan, Andrea M. Reyes-Ortiz, Sarah E. Lutz, Amanda J. Kedaigle, Theresa A. Gipson, Jie Wu, Gad D. Vatine, Jennifer Stocksdale, Malcolm S. Casale, Clive N. Svendsen, Ernest Fraenkel, David E. Housman, Dritan Agalliu, Leslie M. Thompson
Publikováno v:
Cell Reports, Vol 19, Iss 7, Pp 1365-1377 (2017)
Brain microvascular endothelial cells (BMECs) are an essential component of the blood-brain barrier (BBB) that shields the brain against toxins and immune cells. While BBB dysfunction exists in neurological disorders, including Huntington’s disease
Externí odkaz:
https://doaj.org/article/a4c8006ac0ea461986232304206450ef
Autor:
Narek Darabedian, Feimeng Zhou, Ernest Enriquez, Jamil Momand, Wang Zhao, Patrycja Magdziarz, Xiaoying Wang, Chris Quan
Publikováno v:
Analytical Biochemistry. 569:53-58
Docking on the p53-binding site of murine double minute 2 (MDM2) by small molecules restores p53's tumor-suppressor function. We previously assessed 3244 FDA-approved drugs via “computational conformer selection” for inhibiting MDM2 and p53 inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b732e71e558033536f0e481ac5f85501
https://doi.org/10.1016/j.ab.2019.01.012
https://doi.org/10.1016/j.ab.2019.01.012
Autor:
Ernest Fraenkel, Gad D. Vatine, Jie Wu, Dritan Agalliu, Ryan G. Lim, Malcolm Casale, Jennifer Stocksdale, Chris Quan, Clive N. Svendsen, Amanda J. Kedaigle, David E. Housman, Theresa A. Gipson, Sarah E. Lutz, Andrea M. Reyes-Ortiz, Leslie M. Thompson
Publikováno v:
Cell reports
Cell Reports, Vol 19, Iss 7, Pp 1365-1377 (2017)
Elsevier
Lim, RG; Quan, C; Reyes-Ortiz, AM; Lutz, SE; Kedaigle, AJ; Gipson, TA; et al.(2017). Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. CELL REPORTS, 19(7), 1365-1377. doi: 10.1016/j.celrep.2017.04.021. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6z1351tf
Cell Reports, Vol 19, Iss 7, Pp 1365-1377 (2017)
Elsevier
Lim, RG; Quan, C; Reyes-Ortiz, AM; Lutz, SE; Kedaigle, AJ; Gipson, TA; et al.(2017). Huntington's Disease iPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits. CELL REPORTS, 19(7), 1365-1377. doi: 10.1016/j.celrep.2017.04.021. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6z1351tf
Brain microvascular endothelial cells (BMECs) are an essential component of the blood-brain barrier (BBB) that shields the brain against toxins and immune cells. While BBB dysfunction exists in neurological disorders, including Huntington's disease (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1c143fdf0b8a6fc8d5f8ef0cb17a80a
https://pubmed.ncbi.nlm.nih.gov/28514657
https://pubmed.ncbi.nlm.nih.gov/28514657