Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chris Proffitt"'
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
Drug combination therapies are commonly used for the treatment of cancers to increase therapeutic efficacy, reduce toxicity, and decrease the incidence of drug resistance. Although drug combination therapies were originally devised primarily by empir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009230c7b846415ab8368b86d944ad43
https://doi.org/10.1158/1535-7163.c.6536134.v1
https://doi.org/10.1158/1535-7163.c.6536134.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 148K, The effects of CK2, MDC1 or XRCC1 depletion by siRNA on Gamma-H2AX levels induced by cisplatin or gemcitabine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fb6cb4e739d4f966916283f31a97e5
https://doi.org/10.1158/1535-7163.22499401.v1
https://doi.org/10.1158/1535-7163.22499401.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 63K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1724ae25a140fdf37ff1525f0a31ef0d
https://doi.org/10.1158/1535-7163.22499395
https://doi.org/10.1158/1535-7163.22499395
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 97K, Quantified western blots for Gamma-H2AX and cleaved PARP levels normalized to �eta-actin levels from cisplatin or gemcitabine combinations with CX-4945.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62e37083b780678c4a83fbc6e1748ed1
https://doi.org/10.1158/1535-7163.22499404.v1
https://doi.org/10.1158/1535-7163.22499404.v1
Autor:
Denis Drygin, William G. Rice, David M. Ryckman, Daniel D. Von Hoff, John K. C. Lim, Sean E. O'Brien, Chris Proffitt, Kenna Anderes, Caroline B. Ho, Nicole Streiner, Nanni Huser, Mayuko Omori, Diwata Macalino, Joshua Bliesath, Adam Siddiqui-Jain
PDF file - 1.0MB, The global role of CK2 in DNA repair and cancer therapies that potentially rely on CK2 mediated repair mechanisms.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d9190126d915dc4ca655ca09925838
https://doi.org/10.1158/1535-7163.22499398
https://doi.org/10.1158/1535-7163.22499398
Autor:
William G. Rice, Kenna Anderes, Daniel Von Hoff, John K. C. Lim, Jeffrey P. Whitten, Katy Trent, Chris Proffitt, Caroline B. Ho, Josh Bliesath, Amy Lin, Michael Schwaebe, Sean O'Brien, Adam Siddiqui-Jain, Denis Drygin
Supplementary Methods and Materials from Anticancer Activity of CX-3543: A Direct Inhibitor of rRNA Biogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7507050d577b19fc474daaa9d68bdaef
https://doi.org/10.1158/0008-5472.22378134
https://doi.org/10.1158/0008-5472.22378134
Autor:
William G. Rice, Kenna Anderes, David Ryckman, Ross D. Hannan, Megan J. Bywater, Elaine Sanij, Jaclyn E. Quin, Nicole Streiner, Adam Siddiqui-Jain, Michael K. Schwaebe, Mustapha Haddach, Mayuko Omori, Chris Proffitt, Sean E. O'Brien, Caroline B. Ho, Josh Bliesath, Amy Lin, Denis Drygin
Supplementary Materials from Targeting RNA Polymerase I with an Oral Small Molecule CX-5461 Inhibits Ribosomal RNA Synthesis and Solid Tumor Growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0b64b9899bae18205e730a978712b0
https://doi.org/10.1158/0008-5472.22387916.v1
https://doi.org/10.1158/0008-5472.22387916.v1
Autor:
Kenna Anderes, William G. Rice, David M. Ryckman, Michael K. Schwaebe, Chris Proffitt, Caroline Ho, Nanni Huser, Mayuko Omori, Josh Bliesath, Sean E. O'Brien, Fabrice Pierre, Peter Chua, Nicole Streiner, Denis Drygin, Adam Siddiqui-Jain
Supplementary Methods from CX-4945, an Orally Bioavailable Selective Inhibitor of Protein Kinase CK2, Inhibits Prosurvival and Angiogenic Signaling and Exhibits Antitumor Efficacy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c5cc2abcc1fc3202335d6528f4c2a9a
https://doi.org/10.1158/0008-5472.22386579
https://doi.org/10.1158/0008-5472.22386579
Autor:
Kenna Anderes, William G. Rice, David M. Ryckman, Michael K. Schwaebe, Chris Proffitt, Caroline Ho, Nanni Huser, Mayuko Omori, Josh Bliesath, Sean E. O'Brien, Fabrice Pierre, Peter Chua, Nicole Streiner, Denis Drygin, Adam Siddiqui-Jain
Malignant transformation and maintenance of the malignant phenotype depends on oncogenic and non-oncogenic proteins that are essential to mediate oncogene signaling and to support the altered physiologic demands induced by transformation. Protein kin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1119ad46a45018a2830b6d70f1b000dd
https://doi.org/10.1158/0008-5472.c.6501576
https://doi.org/10.1158/0008-5472.c.6501576
Autor:
Paul Tanis, Urmi Banerjee, Ron de Jong, Charles E. Grimshaw, Mark Sabat, Chris Proffitt, Walter Keung, Petro Halkowycz, Kim Peacock, Jacques Ermolieff
Publikováno v:
SLAS Discovery. 26:676-683
Two different signaling pathways lead to the activation of the transcription factor NF-κB, initiating distinct biological responses: The canonical NF-κB pathway activation has been implicated in host immunity and inflammatory responses, whereas the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b487527afd747e2f0032556040ba0
https://doi.org/10.1177/2472555220964450
https://doi.org/10.1177/2472555220964450
