Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Chris Pickford"'
Autor:
Stephen M. Shaw, Jenny Middleton, Kim Wigglesworth, Amber Charlemagne, Oliver Schulz, Melanie S. Glossop, Giles F. Whalen, Robert Old, Mike Westby, Chris Pickford, Rinat Tabakman, Irit Carmi-Levy, Abi Vainstein, Ella Sorani, Arik A. Zur, Sascha A. Kristian
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-19 (2019)
Abstract Background Treatments that generate T cell-mediated immunity to a patient’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualized ex vivo processi
Externí odkaz:
https://doaj.org/article/440a5a0ba0874d0aa71454cddd24f71c
Autor:
Wade S Blair, Chris Pickford, Stephen L Irving, David G Brown, Marie Anderson, Richard Bazin, Joan Cao, Giuseppe Ciaramella, Jason Isaacson, Lynn Jackson, Rachael Hunt, Anne Kjerrstrom, James A Nieman, Amy K Patick, Manos Perros, Andrew D Scott, Kevin Whitby, Hua Wu, Scott L Butler
Publikováno v:
PLoS Pathogens, Vol 6, Iss 12, p e1001220 (2010)
Despite a high current standard of care in antiretroviral therapy for HIV, multidrug-resistant strains continue to emerge, underscoring the need for additional novel mechanism inhibitors that will offer expanded therapeutic options in the clinic. We
Externí odkaz:
https://doaj.org/article/8648c9ca262f41ee91d7fa89fbbd3323
Autor:
Abi Vainstein, Arik A. Zur, Ella Sorani, Giles F. Whalen, Jenny Middleton, Chris Pickford, Melanie S. Glossop, Robert Old, Oliver Schulz, Sascha A. Kristian, Irit Carmi-Levy, Amber Charlemagne, Mike Westby, Rinat Tabakman, Kim Wigglesworth, Stephen M. Shaw
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-19 (2019)
Cancer Cell International
Cancer Cell International
BackgroundTreatments that generate T cell-mediated immunity to a patient’s unique neoantigens are the current holy grail of cancer immunotherapy. In particular, treatments that do not require cumbersome and individualized ex vivo processing or manu
Autor:
Kathy F. K. Cheung, Jean-Yves Chiva, Satish Dayal, Darren Stead, Carly L. Nichols, Rob Webster, Lee R. Roberts, David Stonehouse, Felice Daverio, Iain Gardner, Andrew Pike, Michael Paradowski, David C. Blakemore, Gilles H. Goetz, Lesa Watson, Chris Pickford, Jared B.J. Milbank, Ye Che, Robert Wybrow, Florian Wakenhut, Keith Statham, Caroline Smith-Burchnell, Samuel Crook, Fiona M. Adam, David C. Pryde, David Leese, Mike Westby, Duncan Hay, Stephen M. Shaw, Tram T. Tran
Publikováno v:
ChemMedChem. 9:1378-1386
Nonstructural protein 5A (NS5A) represents a novel target for the treatment of hepatitis C virus (HCV). Daclatasvir, recently reported by Bristol-Myers-Squibb, is a potent NS5A inhibitor currently under investigation in phase 3 clinical trials. While
Autor:
Stephen M. Shaw, David C. Pryde, Thien Duc Tran, Chris Pickford, Caroline Smith-Burchnell, M. J. Gardner, Rob Webster, Satish Dayal, Mike Westby, Tanya Parkinson
Publikováno v:
Open Journal of Medicinal Chemistry. :16-25
A high throughput screen of the Pfizer compound collection was carried out using a hepatitis C virus (HCV) genotype 1b subgenomic replicon cell line. Those confirmed hits that demonstrated broad spectrum activity without overt cytotoxicity were furth
Autor:
David C. Pryde, Edward J. Murray, Kevin Brady, Chris Pickford, Jaiessh Rawal, Carl Laxton, Sterghios Moschos, Ben Sidders, Romuald Corbau, Paul Turnpenny
Publikováno v:
Antimicrobial Agents and Chemotherapy. 55:3105-3114
We have screened 47 locked nucleic acid (LNA) antisense oligonucleotides (ASOs) targeting conserved (>95% homology) sequences in the hepatitis C virus (HCV) genome using the subgenomic HCV replicon assay and generated both antiviral (50% effective co
Autor:
Joan Cao, Hua Wu, Paul Griffin, Qinghai Peng, R. Lynn Jackson, Scott L. Butler, Wade S. Blair, Edward J. Murray, Chris Pickford, Amy K. Patick, Juin Fok-Seang, Manos Perros, Jason Isaacson
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:5080-5087
A new small-molecule inhibitor class that targets virion maturation was identified from a human immunodeficiency virus type 1 (HIV-1) antiviral screen. PF-46396, a representative molecule, exhibits antiviral activity against HIV-1 laboratory strains
Autor:
Chris Pickford
Publikováno v:
Cultural Trends. 12:1-36
This chapter of Cultural Trends examines the increasing use of statistical data to support evidence‐based management in the archival domain. After explaining how archives are managed and used, it reviews the available sources of data and evidence a
Autor:
Florian Wakenhut, Thien Duc Tran, Chris Pickford, Stephen Shaw, Mike Westby, Caroline Smith-Burchnell, Lesa Watson, Michael Paradowski, Jared Milbank, David Stonehouse, Kathy Cheung, Robert Wybrow, Felice Daverio, Samuel Crook, Keith Statham, David Leese, Darren Stead, Fiona Adam, Duncan Hay, Lee R. Roberts, Jean-Yves Chiva, Carly Nichols, David C. Blakemore, Gilles H. Goetz, Ye Che, Iain Gardner, Satish Dayal, Andrew Pike, Rob Webster, David C. Pryde
Publikováno v:
ChemMedChem. 9(7)
In ongoing studies towards novel hepatitis C virus (HCV) therapeutics, inhibitors of nonstructural protein 5A (NS5A) were evaluated. Specifically, starting from previously reported lead compounds, peripheral substitution patterns of a series of biary
Autor:
Chris Pickford
Publikováno v:
Journal of the Society of Archivists. 20:169-176
Catalogage d'archives: dans le contexte de la reduction des credits alloues aux archivistes, l'auteur examine les avantages et inconvenients du catalogage sous contrat, qui regroupe l'emploi de personne a contrat a duree determinee et le recours a la