Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Chris Papagiannis"'
Impurity Qualification Toxicology Study for a 2′-O-Methoxyethyl-Modified Antisense Inhibitor in Mice
Autor:
Andrew McPherson, Scott P. Henry, David Serota, Daniel C. Capaldi, Christine Hoffmaster, Nhuy Luu, Farah Mahdi, Tae-Won Kim, Andrew A. Rodriguez, Chris Papagiannis
Publikováno v:
Nucleic Acid Therapeutics. 30:14-21
Safety assessment of drug impurities is a routine part of the drug development process. For oligonucleotide-based drugs, impurities can arise from impurities in starting materials, as by-products of the manufacturing process or from degradation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f99d214878773961d132295dbdea87
https://doi.org/10.1089/nat.2019.0780
https://doi.org/10.1089/nat.2019.0780
Autor:
Laura S. Zwick, Jill Hsiao, Chris Papagiannis, Jeffery A. Engelhardt, Noah Post, Scott P. Henry, Tae-Won Kim, John Matson, Sebastien A. Burel, Christine Hoffmaster
Publikováno v:
Toxicologic Pathology. 47:82-92
The 6-month Tg.rasH2 mouse carcinogenicity model provides an acceptable alternative to the 2-year carcinogenicity study in CD-1 mice. However, key questions related to the use of this model for testing antisense oligonucleotides (ASOs) include the si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed325a89e476f09f74e7b9d13217d065
https://doi.org/10.1177/0192623318813143
https://doi.org/10.1177/0192623318813143
Autor:
Lijiang Shen, David Serota, Shin-Young Park, Yunlip Kim, Tae-Won Kim, Scott P. Henry, Thomas A. Zanardi, Chris Papagiannis
Publikováno v:
Nucleic Acid Therapeutics. 28:233-241
Advances in antisense oligonucleotide (ASO) chemistry and screening have enabled the design and selection of molecules that are optimized for a particular therapeutic application in terms of both potency and tolerability. The most-well studied of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e80347a09bd5880bea4914003221101
https://doi.org/10.1089/nat.2017.0706
https://doi.org/10.1089/nat.2017.0706