Výsledky vyhledávání - "Chris P. M. Broeren"

Cartilage proteoglycan-specific T cells as vectors of immunomodulatory biologicals in chronic proteoglycan-induced arthritis

Autor: Floris P J G Lafeber, Willem van Eden, Femke Broere, Teun Guichelaar, Corlinda ten Brink, Suzanne E. Berlo, Peter J.S. van Kooten, Chris P. M. Broeren

Publikováno v: Molecular Immunology. 45:3526-3535

Systemic administration of agents that neutralize or antagonize Th1-mediated pro-inflammatory responses has been demonstrated to ameliorate inflammation in chronic autoimmune disease. However, systemic administration of such immunosuppressive biologi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89887e9d048ca40396d9873375707bd6
https://doi.org/10.1016/j.molimm.2008.05.008

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Naive transgenic T cells expressing cartilage proteoglycan-specific TCR induce arthritis upon in vivo activation

Autor: W. van Eden, Suzanne E. Berlo, F Hauet-Broere, Mariëtte A. Oosterwegel, Peter J.S. van Kooten, Chris P. M. Broeren, Corlinda ten Brink, Tibor T. Glant

Publikováno v: Journal of Autoimmunity. 25:172-180

Proteoglycan (PG)-induced arthritis (PGIA), a murine model for rheumatoid arthritis (RA), is driven by antigen (PG)-specific T and B cell activation. In order to analyze the pathogenic role of antigen-specific T cells in the development of autoimmune

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87c9a3bdfca885c5f4e7b633fb0a75b
https://doi.org/10.1016/j.jaut.2005.09.017

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ICOS Contributes to T Cell Expansion in CTLA-4 Deficient Mice

Autor: Chris P. M. Broeren, Mariëtte A. Oosterwegel, Frans M. A. Hofhuis, Anthony J. Coyle, Kiki Tesselaar, Elise H. R. Schrijver, Arlene H. Sharpe, Miranda E.A.T. van Berkel

Publikováno v: The Journal of Immunology. 175:182-188

Both CD28 and ICOS are important costimulatory molecules that promote Ag-specific cellular and humoral immune reactions. Whereas CD28 is generally thought to be the most important molecule in the initiation of a T cell response, ICOS is considered to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c59b73990052b4086535045f0d9a47e
https://doi.org/10.4049/jimmunol.175.1.182

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Effector and regulatory T?cells derived from the same T?cell clone differ in MHC class II-peptide multimer binding

Autor: Jetty G. Veenstra, Mayken C. Grosfeld-Stulemeyer, Willem van Eden, Chris P. M. Broeren, Marca H. M. Wauben, Maria Grazia Amoroso, Esther N. M. Nolte-‘t Hoen

Publikováno v: European Journal of Immunology. 34:3359-3369

MHC class II-peptide multimers are a valuable tool for antigen-specific detection of CD4(+) T cells. However, it has been proposed that T cells in a hypo-responsive state can have diminished binding of such multimers. In the present study, we investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a9a7b9376e319fe50a7cfec946597f
https://doi.org/10.1002/eji.200425563

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Achievement of a synergistic adjuvant effect on arthritis induction by activation of innate immunity and forcing the immune response toward the Th1 phenotype

Autor: Suzanne E. Berlo, Katalin Mikecz, Chris P. M. Broeren, Sándor Szántó, Anita Hanyecz, Tibor T. Glant

Publikováno v: Arthritis & Rheumatism. 50:1665-1676

Objective To apply and analyze the mechanisms of action of dimethyldioctadecylammonium bromide (DDA), a powerful adjuvant that does not have the side effects of the conventionally used Freund's adjuvants, in proteoglycan-induced arthritis (PGIA) and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7784d64b579c74a1dc4a84d7856e709
https://doi.org/10.1002/art.20180

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Lack of Coreceptor Allows Survival of Chronically Stimulated Double-Negative α/β T Cells

Autor: Jonathan P. Schneck, Chris P. M. Broeren, Drew M. Pardoll, Carl H. June, Paria Mirmonsef, Abdel Rahim A. Hamad, Ananth Srikrishnan

Publikováno v: The Journal of Experimental Medicine

Lymphoproliferative diseases are characterized by massive accumulation of CD4(-)CD8(-)B220(+) (double-negative [DN]) T cells in peripheral organs. Although evidence indicates these cells are derived from mature autoreactive alpha/beta T cells, the si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1157937fb6f8ed03f9c7f344eef68c24
https://doi.org/10.1084/jem.193.10.1113

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Nasal application of a naturally processed and presented T cell epitope derived from TCR AV11 protects against adjuvant arthritis

Autor: Chris P. M. Broeren, Esther A. E. van Tienhoven, Willem van Eden, Marca H. M. Wauben, J. P. A. Wagenaar, Alida Noordzij

Publikováno v: International Immunology. 12:1715-1721

Reactivity towards TCR peptides plays an important role in the regulation of several experimental autoimmune diseases. In a previous paper, we showed the TCRAV11 usage by an arthritogenic T cell clone isolated from a rat with adjuvant arthritis (AA).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f65074a126b6f391e35a4e68902ae4f
https://doi.org/10.1093/intimm/12.12.1715

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Generation and Characterization of a Clonotypic Antibody Specific for the T Cell Receptor of an Arthritogenic T Cell Clone—Studies in Adjuvant Arthritis

Autor: Maarten J. F. van der Cammen, Esther A. E. van Tienhoven, Willem van Eden, Chris P. M. Broeren, Peter G. A. Steenbakkers, Jetty G. Veenstra, Peter J.S. van Kooten

Publikováno v: Journal of Autoimmunity. 15:1-8

Adjuvant Arthritis (AA) can be induced by passive transfer of a T cell clone (A2b) derived from arthritic rats, specific for Heat Shock Protein 60, HSP60 176-190. Furthermore, a crucial role for T cells with HSP60 176-190 specificity in AA was shown

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::154d18f4249c65dd4347c452ae0ed292
https://doi.org/10.1006/jaut.2000.0384

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Induction of experimental autoimmune arthritis by a public epitope of the T cell receptor variable α domain of an arthritogenic T cell clone

Autor: Jetty G. Veenstra, Esther A. E. van Tienhoven, Willem van Eden, Chris P. M. Broeren, Marein H. van der Hage, Peter J.S. van Kooten

Publikováno v: European Journal of Immunology. 30:2164-2171

T cell receptor (TCR) peptide immunizations have been demonstrated to protect against experimental autoimmune diseases. These findings have led to clinical trials employing TCR peptides in multiple sclerosis and rheumatoid arthritis patients. Previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::055bcf966990fbd73b51ab21b67f6613
https://doi.org/10.1002/1521-4141(2000)30:8<2164::aid-immu2164>3.0.co

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