Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Chris P. Barnes"'
Autor:
Jack W. Rutter, Linda Dekker, Chania Clare, Zoe F. Slendebroek, Kimberley A. Owen, Julie A. K. McDonald, Sean P. Nair, Alex J. H. Fedorec, Chris P. Barnes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Bacteriocins are antimicrobial peptides that are naturally produced by many bacteria. They hold great potential in the fight against antibiotic resistant bacteria, including ESKAPE pathogens. Engineered live biotherapeutic products (eLBPs) t
Externí odkaz:
https://doaj.org/article/8ca6366764d747bfa545638bbe0e2cfe
Autor:
Alex J. H. Fedorec, Neythen J. Treloar, Ke Yan Wen, Linda Dekker, Qing Hsuan Ong, Gabija Jurkeviciute, Enbo Lyu, Jack W. Rutter, Kathleen J. Y. Zhang, Luca Rosa, Alexey Zaikin, Chris P. Barnes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Biological computing is a promising field with potential applications in biosafety, environmental monitoring, and personalized medicine. Here we present work on the design of bacterial computers using spatial patterning to process informatio
Externí odkaz:
https://doaj.org/article/73b0d8d21e8b4dfba9f90eadbd2fb609
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Phylogenetic trees based on copy number profiles from multiple samples of a patient are helpful to understand cancer evolution. Here, we develop a new maximum likelihood method, CNETML, to infer phylogenies from such data. CNETML is the firs
Externí odkaz:
https://doaj.org/article/5e78e58832ea49fca3b1f1cb351c076f
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106836- (2023)
Summary: Recent advances in synthetic biology are enabling exciting technologies, including the next generation of biosensors, the rational design of cell memory, modulated synthetic cell differentiation, and generic multifunctional biocircuits. Thes
Externí odkaz:
https://doaj.org/article/150a52e5bf0a4e9aa0c4676dbb134acc
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The human microbiota is implicated in many disease states, including neurological disorders, cancer, and inflammatory diseases. This potentially huge impact on human health has prompted the development of microbiome engineering methods, which attempt
Externí odkaz:
https://doaj.org/article/0be154c1cd0e41f0aafb1e48828fa5db
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Engineered microbial communities can divide labour between their members and interface with natural microbiomes. Here the authors demonstrate how a single toxin producing engineered strain can tune the composition of a two-strain community.
Externí odkaz:
https://doaj.org/article/887faf91789241d4a37f46217077dc57
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
In naturally occurring microbial systems, there is a positive relationship between species diversity and productivity of the community. Here the authors perform model selection to find potential amensal interactions that yield robust stable synthetic
Externí odkaz:
https://doaj.org/article/0ac42a39021a487e8630d12c4ab457fb
Autor:
Benjamin Werner, Jack Case, Marc J. Williams, Ketevan Chkhaidze, Daniel Temko, Javier Fernández-Mateos, George D. Cresswell, Daniel Nichol, William Cross, Inmaculada Spiteri, Weini Huang, Ian P. M. Tomlinson, Chris P. Barnes, Trevor A. Graham, Andrea Sottoriva
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Quantifying somatic evolutionary processes in cancer and healthy tissue is a challenge. Here, the authors use single time point multi-region sampling of cancer and normal tissue, combined with evolutionary theory, to quantify in vivo mutation and cel
Externí odkaz:
https://doaj.org/article/1cc8e57a38b3428da9bd484790ebf103
Autor:
Alex J.H. Fedorec, Tanel Ozdemir, Anjali Doshi, Yan-Kay Ho, Luca Rosa, Jack Rutter, Oscar Velazquez, Vitor B. Pinheiro, Tal Danino, Chris P. Barnes
Publikováno v:
iScience, Vol 14, Iss , Pp 323-334 (2019)
Summary: Plasmids are the workhorse of both industrial biotechnology and synthetic biology, but ensuring they remain in bacterial cells is a challenge. Antibiotic selection cannot be used to stabilize plasmids in most real-world applications, and ins
Externí odkaz:
https://doaj.org/article/7fc97d305d384cc1b919e95418a68bcc
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
A distributed biological system can be defined as a system whose components are located in different subpopulations, which communicate and coordinate their actions through interpopulation messages and interactions. We see that distributed systems are
Externí odkaz:
https://doaj.org/article/7e8d178974a740f4af8cada43d41a525