Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Chris P. Barnes"'
Autor:
Jack W. Rutter, Linda Dekker, Chania Clare, Zoe F. Slendebroek, Kimberley A. Owen, Julie A. K. McDonald, Sean P. Nair, Alex J. H. Fedorec, Chris P. Barnes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Bacteriocins are antimicrobial peptides that are naturally produced by many bacteria. They hold great potential in the fight against antibiotic resistant bacteria, including ESKAPE pathogens. Engineered live biotherapeutic products (eLBPs) t
Externí odkaz:
https://doaj.org/article/8ca6366764d747bfa545638bbe0e2cfe
Autor:
Alex J. H. Fedorec, Neythen J. Treloar, Ke Yan Wen, Linda Dekker, Qing Hsuan Ong, Gabija Jurkeviciute, Enbo Lyu, Jack W. Rutter, Kathleen J. Y. Zhang, Luca Rosa, Alexey Zaikin, Chris P. Barnes
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Biological computing is a promising field with potential applications in biosafety, environmental monitoring, and personalized medicine. Here we present work on the design of bacterial computers using spatial patterning to process informatio
Externí odkaz:
https://doaj.org/article/73b0d8d21e8b4dfba9f90eadbd2fb609
Autor:
Lisa Lancaster, Vincent Cottin, Murali Ramaswamy, Wim A. Wuyts, R. Gisli Jenkins, Mary Beth Scholand, Michael Kreuter, Claudia Valenzuela, Christopher J. Ryerson, Jonathan Goldin, Grace Hyun J. Kim, Marzena Jurek, Martin Decaris, Annie Clark, Scott M. Turner, Chris N. Barnes, Hardean E. Achneck, Gregory P. Cosgrove, Éric A. Lefebvre, Kevin R. Flaherty
Publikováno v:
Therapeutic Advances in Respiratory Disease, Vol 18 (2024)
What is this summary about? This plain language summary shares results from a clinical study called INTEGRIS-IPF that was published in the American Journal of Respiratory and Critical Care Medicine in 2024. This study looked at a medicine called bexo
Externí odkaz:
https://doaj.org/article/d74c3c5acaf94d3797a66223b9ad603c
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-28 (2023)
Abstract Phylogenetic trees based on copy number profiles from multiple samples of a patient are helpful to understand cancer evolution. Here, we develop a new maximum likelihood method, CNETML, to infer phylogenies from such data. CNETML is the firs
Externí odkaz:
https://doaj.org/article/5e78e58832ea49fca3b1f1cb351c076f
Autor:
Mario Sznol, Adil Daud, Scott M Turner, Chris N Barnes, Susan Owen, Eric A Lefebvre, Hardean E Achneck
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/b58dd5cb21174445b278c917f39dc879
Publikováno v:
iScience, Vol 26, Iss 6, Pp 106836- (2023)
Summary: Recent advances in synthetic biology are enabling exciting technologies, including the next generation of biosensors, the rational design of cell memory, modulated synthetic cell differentiation, and generic multifunctional biocircuits. Thes
Externí odkaz:
https://doaj.org/article/150a52e5bf0a4e9aa0c4676dbb134acc
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 11, p e1010695 (2022)
The field of optimal experimental design uses mathematical techniques to determine experiments that are maximally informative from a given experimental setup. Here we apply a technique from artificial intelligence-reinforcement learning-to the optima
Externí odkaz:
https://doaj.org/article/368750c01d7144d797d7622f55dae466
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 10, p e1010548 (2022)
Predictability is a fundamental requirement in biological engineering. As we move to building coordinated multicellular systems, the potential for such systems to display chaotic behaviour becomes a concern. Therefore understanding which systems show
Externí odkaz:
https://doaj.org/article/72ee517f9eb94601a1fe8115e86d6f6d
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
The human microbiota is implicated in many disease states, including neurological disorders, cancer, and inflammatory diseases. This potentially huge impact on human health has prompted the development of microbiome engineering methods, which attempt
Externí odkaz:
https://doaj.org/article/0be154c1cd0e41f0aafb1e48828fa5db
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Engineered microbial communities can divide labour between their members and interface with natural microbiomes. Here the authors demonstrate how a single toxin producing engineered strain can tune the composition of a two-strain community.
Externí odkaz:
https://doaj.org/article/887faf91789241d4a37f46217077dc57