Výsledky vyhledávání - "Chris P. Carron"

Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)

Publikováno v: ACS Medicinal Chemistry Letters. 1:59-63

Hematopoietic prostaglandin D synthase (HPGDS) is primarly expressed in mast cells, antigen-presenting cells, and Th-2 cells. HPGDS converts PGH2 into PGD2, a mediator thought to play a pivotal role in airway allergy and inflammatory processes. In th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e6559b7ee90a239bc2255e65f4dd700
https://doi.org/10.1021/ml900025z

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Multifunctional Role of Matrix Metalloproteinases in Multiple Myeloma

Autor: Ben Van Camp, Agnès Noël, S. Blacher, Hendrik De Raeve, Peter I. Croucher, Evy De Leenheer, Elke De Bruyne, Kewal Asosingh, Chris P. Carron, Laetitia Devy, Karin Vanderkerken, Ivan Van Riet, Els Van Valckenborgh

Publikováno v: The American Journal of Pathology. 165:869-878

Matrix metalloproteinases (MMPs) are known to play a role in cell growth, invasion, angiogenesis, metastasis, and bone degradation, all important events in the pathogenesis of cancer. Multiple myeloma is a B-cell cancer characterized by the prolifera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d3f57a08740df5dd35a931b37a43847
https://doi.org/10.1016/s0002-9440(10)63349-4

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Orally active MMP-1 sparing α-tetrahydropyranyl and α-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease

Publikováno v: Journal of medicinal chemistry. 53(18)

α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP's-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9685357a0ce79c92aebc66064d268699
https://pubmed.ncbi.nlm.nih.gov/20726512

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Synthesis and structure-activity relationships of beta- and alpha-piperidine sulfone hydroxamic acid matrix metalloproteinase inhibitors with oral antitumor efficacy

Autor: Chris P. Carron, Craig Swearingen, Louis J. Bedell, John N. Freskos, Getman Daniel P, Clara I. Villamil, Grace E. Munie, Pramod P. Mehta, Boehm Terri L, Barta Thomas E, Madeleine H. Li, Daniel P. Becker, Susan L. Hockerman, Susan C. Howard, Heintz Robert M, Joseph J. McDonald, Chris L. Funckes-Shippy, Decrescenzo Gary A

Publikováno v: Journal of medicinal chemistry. 48(21)

alpha-Piperidine-beta-sulfone hydroxamate derivatives were explored that are potent for matrix metalloproteinases (MMP)-2, -9, and -13 and are sparing of MMP-1. The investigation of the beta-sulfones subsequently led to the discovery of hitherto unkn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0539500154a05a00e3a097afebbcc7a1
https://pubmed.ncbi.nlm.nih.gov/16220987

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Akademický článek

Orally Active MMP-1 Sparing Î±-Tetrahydropyranyl and Î±-Piperidinyl Sulfone Matrix Metalloproteinase (MMP) Inhibitors with Efficacy in Cancer, Arthritis, and Cardiovascular Disease.

Publikováno v: Journal of Medicinal Chemistry; Sep2010, Vol. 53 Issue 18, p6653-6680, 28p

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