Extracellular histone release by renal cells after warm and cold ischemic kidney injury: Studies in an ex-vivo porcine kidney perfusion model.

Autor: Tim C van Smaalen, Danielle M H Beurskens, Jasper J H F M Kox, Rasheendra Polonia, Rein Vos, Hans Duimel, Willine J van de Wetering, Carmen López-Iglesias, Chris P Reutelingsperger, L W Ernest van Heurn, Carine J Peutz-Kootstra, Gerry A F Nicolaes

Publikováno v: PLoS ONE, Vol 18, Iss 1, p e0279944 (2023)

Extracellular histones are cytotoxic molecules involved in experimental acute kidney injury. In patients receiving a renal transplant from donors after circulatory death, who suffer from additional warm ischemia, worse graft outcome is associated wit

Externí odkaz: https://doaj.org/article/7fcf7b59f41e4937a8360811da496825

Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake.

Autor: Lisette Ungethüm, Martijn Chatrou, Dennis Kusters, Leon Schurgers, Chris P Reutelingsperger

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e96749 (2014)

OBJECTIVE: Annexin A5 is a phosphatidylserine binding protein that binds dying cells in vivo. Annexin A5 is a potential molecular imaging agent to determine efficacy of anti-cancer therapy in patients. Its rapid clearance from circulation limits tumo

Externí odkaz: https://doaj.org/article/4d40efdb47d64d87920a53357e92b364

Thrombin formation via the intrinsic coagulation pathway and von Willebrand factor reflect disease severity in COVID-19

Autor: Matthias H. Busch, Sjoerd A.M.E.G. Timmermans, Sander M.J. van Kuijk, Joop P. Aendekerk, Renée Ysermans, Daan P.C. van Doorn, Judith Potjewijd, Marcel C.G. van de Poll, Iwan C.C. van der Horst, Jan G.M.C. Damoiseaux, Henri M.H. Spronk, Hugo ten Cate, Chris P. Reutelingsperger, Magdolna Nagy, Pieter van Paassen

Publikováno v: Haematologica, Vol 108, Iss 5 (2022)

Externí odkaz: https://doaj.org/article/55284b83a415478094a0ea8b35520580

Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification

Autor: Angelina Pavlic, Hessel Poelman, Grzegorz Wasilewski, Kanin Wichapong, Petra Lux, Cecile Maassen, Esther Lutgens, Leon J. Schurgers, Chris P. Reutelingsperger, Gerry A. F. Nicolaes

Publikováno v: International Journal of Molecular Sciences, 24(3):2027. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences
Volume 24
Issue 3
Pages: 2027

Vascular calcification (VC) is an important contributor and prognostic factor in the pathogenesis of cardiovascular diseases. VC is an active process mediated by the release of extracellular vesicles by vascular smooth muscle cells (VSMCs), and the e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af842856a00eb07bba40376f3534ff1
https://cris.maastrichtuniversity.nl/en/publications/a0fa20a7-7d28-4977-a1c7-9c1f65721721

Annexin A1 Is Associated with Adverse Clinical Outcomes in Patients with COVID-19

Autor: Matthias H. Busch, Sjoerd A. M. E. G. Timmermans, Joop P. Aendekerk, Renée Ysermans, Jean Amiral, Jan G. M. C. Damoiseaux, Chris P. Reutelingsperger, Pieter van Paassen

Publikováno v: Journal of Clinical Medicine; Volume 11; Issue 24; Pages: 7486
Journal of Clinical Medicine, 11(24):7486. Multidisciplinary Digital Publishing Institute (MDPI)

Severe coronavirus disease 2019 (COVID-19) is characterized by hyperinflammation, vascular damage, and hypercoagulability. Insufficient responses of Annexin A1 (AnxA1), a pro-resolving inhibitor of neutrophil infiltration and activation, might contri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed2c79ee0fae2d15ee868b6f9f19c03
https://doi.org/10.3390/jcm11247486