Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Chris Neale"'
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-16 (2024)
Abstract The oncogene RAS, extensively studied for decades, presents persistent gaps in understanding, hindering the development of effective therapeutic strategies due to a lack of precise details on how RAS initiates MAPK signaling with RAF effecto
Externí odkaz:
https://doaj.org/article/c9c372b885d34294a1a4b151fe83ce95
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract Bacterial microcompartments (BMCs) are protein organelles consisting of an inner enzymatic core encased within a selectively permeable shell. BMC shells are modular, tractable architectures that can be repurposed with new interior enzymes fo
Externí odkaz:
https://doaj.org/article/c6863fa8c3a44ced87209fc49deae4b8
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Understanding of GPCR activation is limited as the structural information fails to present the full spectrum of energy landscape. Here, authors establish a series of conformation-biased mutants that represent five conformational states lying along ad
Externí odkaz:
https://doaj.org/article/b7129c92bb9d4c9089901c9b8c559634
Autor:
Rebika Shrestha, Timothy S. Carpenter, Que N. Van, Constance Agamasu, Marco Tonelli, Fikret Aydin, De Chen, Gulcin Gulten, James N. Glosli, Cesar A. López, Tomas Oppelstrup, Chris Neale, Sandrasegaram Gnanakaran, William K. Gillette, Helgi I. Ingólfsson, Felice C. Lightstone, Andrew G. Stephen, Frederick H. Streitz, Dwight V. Nissley, Thomas J. Turbyville
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/ebd31f95883b42a68c6081c546cb6fe3
Autor:
Dennis D. Fernandes, Chris Neale, Gregory-Neal W. Gomes, Yuchong Li, Aimen Malik, Aditya Pandey, Alexander P. Orazietti, Xudong Wang, Libin Ye, R. Scott Prosser, Claudiu C. Gradinaru
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract G protein-coupled receptors (GPCRs) are the largest class of transmembrane proteins, making them an important target for therapeutics. Activation of these receptors is modulated by orthosteric ligands, which stabilize one or several states w
Externí odkaz:
https://doaj.org/article/1d5a6aaa4ef3450b9bd0c50f9ac512ec
Autor:
Timothy H. Tran, Albert H. Chan, Lucy C. Young, Lakshman Bindu, Chris Neale, Simon Messing, Srisathiyanarayanan Dharmaiah, Troy Taylor, John-Paul Denson, Dominic Esposito, Dwight V. Nissley, Andrew G. Stephen, Frank McCormick, Dhirendra K. Simanshu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The molecular details of the RAS-RAF interaction are still not fully understood. Here, the authors present crystal structures of wild-type and mutant KRAS in complex with the RAS-binding and membrane-interacting cysteine-rich domains of RAF1, and pro
Externí odkaz:
https://doaj.org/article/8075c5993bfb4f61bc8bb5d453321337
Autor:
Steve Cinderby, Diane Archer, Vishal K. Mehta, Chris Neale, Romanus Opiyo, Rachel M. Pateman, Cassilde Muhoza, Charrlotte Adelina, Heidi Tuhkanen
Publikováno v:
Frontiers in Sociology, Vol 7 (2022)
Externí odkaz:
https://doaj.org/article/24721453fbe5475f9cc951b9f812c00f
Autor:
Steve Cinderby, Diane Archer, Vishal K. Mehta, Chris Neale, Romanus Opiyo, Rachel M. Pateman, Cassilde Muhoza, Charrlotte Adelina, Heidi Tuhkanen
Publikováno v:
Frontiers in Sociology, Vol 6 (2021)
To ensure future sustainability, cities need to consider concepts of livability and resident wellbeing alongside environmental, economic and infrastructure development equity. The current rapid urbanization experienced in many regions is leading to s
Externí odkaz:
https://doaj.org/article/b6b70619f17d493e8ae3393fe7f48fe2
Autor:
Chris Neale, Alistair Griffiths, Lauriane Suyin Chalmin-Pui, Sanjana Mendu, Mehdi Boukhechba, Jenny Roe
Publikováno v:
Wellbeing, Space and Society, Vol 2, Iss , Pp 100038- (2021)
Evidence shows green space exposure has beneficial impacts on psychological and physiological wellbeing. However, aesthetic differences in color use in cultivated garden landscapes on wellbeing remains unexplored. This study investigates how warm and
Externí odkaz:
https://doaj.org/article/1f847eb33ee1460ea647eb0b3d12ce71
Publikováno v:
Frontiers in Public Health, Vol 8 (2020)
The benefits of walking in older age include improved cognitive health (e.g., mental alertness, improved memory functioning) and a reduced risk of stress, depression and dementia. However, research capturing the benefits of walking among older people
Externí odkaz:
https://doaj.org/article/c183b7ef41af4aafa13c7ac3fbd14d74