Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Chris N. Goulbourne"'
Autor:
Pasquale D’Acunzo, Elentina K. Argyrousi, Jonathan M. Ungania, Yohan Kim, Steven DeRosa, Monika Pawlik, Chris N. Goulbourne, Ottavio Arancio, Efrat Levy
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-14 (2024)
Abstract Background Hypometabolism tied to mitochondrial dysfunction occurs in the aging brain and in neurodegenerative disorders, including in Alzheimer’s disease, in Down syndrome, and in mouse models of these conditions. We have previously shown
Externí odkaz:
https://doaj.org/article/152d303abcc5498582c312cac72d05ac
Autor:
Bryan J. González, Haoquan Zhao, Jacqueline Niu, Damian J. Williams, Jaeyop Lee, Chris N. Goulbourne, Yuan Xing, Yong Wang, Jose Oberholzer, Maria H. Blumenkrantz, Xiaojuan Chen, Charles A. LeDuc, Wendy K. Chung, Henry M. Colecraft, Jesper Gromada, Yufeng Shen, Robin S. Goland, Rudolph L. Leibel, Dieter Egli
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
hPSCs model of Maturity Onset Diabetes of the Young caused by mutations in the transcription factor HNF1A (HNF1A-MODY), regulates the expression of genes required for the formation of dense-core insulin granules and calcium-dependent insulin secretio
Externí odkaz:
https://doaj.org/article/aaec8b98bed94ed097cfc4ed5a54e814
Autor:
Rita De Gasperi, Chenglin Mo, Daniella Azulai, Zhiying Wang, Lauren M. Harlow, Yating Du, Zachary Graham, Jiangping Pan, Xin‐hua Liu, Lei Guo, Bin Zhang, Fred Ko, Ashleigh M. Raczkowski, William A. Bauman, Chris N. Goulbourne, Wei Zhao, Marco Brotto, Christopher P. Cardozo
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 13, Iss 1, Pp 454-466 (2022)
Abstract Background The role of Numb, a protein that is important for cell fate and development and that, in human muscle, is expressed at reduced levels with advanced age, was investigated; adult mice skeletal muscle and its localization and functio
Externí odkaz:
https://doaj.org/article/e3de719d0af0427d8b54e419b4474d11
Autor:
Pasquale D'Acunzo, Jonathan M. Ungania, Yohan Kim, Bryana R. Barreto, Steven DeRosa, Monika Pawlik, Stefanie Canals‐Baker, Hediye Erdjument‐Bromage, Audrey Hashim, Chris N. Goulbourne, Thomas A. Neubert, Mariko Saito, Henry Sershen, Efrat Levy
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 1, Pp n/a-n/a (2023)
Abstract Cocaine, an addictive psychostimulant, has a broad mechanism of action, including the induction of a wide range of alterations in brain metabolism and mitochondrial homeostasis. Our group recently identified a subpopulation of non‐microves
Externí odkaz:
https://doaj.org/article/ef1beae90ae14629ba8533a2a1dcee1e
Autor:
François-Xavier Blaudin de Thé, Benjamin Lassus, Ari W. Schaler, Stephanie L. Fowler, Chris N. Goulbourne, Ross Jeggo, Clotilde Mannoury la Cour, Mark J. Millan, Karen E. Duff
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract In Alzheimer’s disease and related tauopathies, trans-synaptic transfer and accumulation of pathological tau from donor to recipient neurons is thought to contribute to disease progression, but the underlying mechanisms are poorly understo
Externí odkaz:
https://doaj.org/article/6ec10d2a588a40fb82206e796520623e
Autor:
Leroy C. Joseph, Michael V. Reyes, Edwin A. Homan, Blake Gowen, Uma Mahesh R. Avula, Chris N. Goulbourne, Elaine Y. Wan, John W. Elrod, John P. Morrow
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Obesity and diabetes increase the risk of arrhythmia and sudden cardiac death. However, the molecular mechanisms of arrhythmia caused by metabolic abnormalities are not well understood. We hypothesized that mitochondrial dysfunction caused b
Externí odkaz:
https://doaj.org/article/3583dde928184485acfbb8b933a21ddc
Autor:
Haibo Jiang, Chris N. Goulbourne, Angelica Tatar, Kirsten Turlo, Daniel Wu, Anne P. Beigneux, Chris R.M. Grovenor, Loren G. Fong, Stephen G. Young
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 2156-2166 (2014)
Nanoscale secondary ion MS (NanoSIMS) imaging makes it possible to visualize stable isotope-labeled lipids in cells and tissues at 50 nm lateral resolution. Here we report the use of NanoSIMS imaging to visualize lipids in mouse cells and tissues. Af
Externí odkaz:
https://doaj.org/article/ac8bd3ed0c654492872e584920e42d24
Autor:
Brandon S.J. Davies, Chris N. Goulbourne, Richard H. Barnes, II, Kirsten A. Turlo, Peter Gin, Sue Vaughan, David J. Vaux, André Bensadoun, Anne P. Beigneux, Loren G. Fong, Stephen G. Young
Publikováno v:
Journal of Lipid Research, Vol 53, Iss 12, Pp 2690-2697 (2012)
Lipoprotein lipase (LPL) is secreted into the interstitial spaces by adipocytes and myocytes but then must be transported to the capillary lumen by GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells. The mechanism
Externí odkaz:
https://doaj.org/article/39ccf5f8d4b84b0184c04c6d5c9a6831
Autor:
Ju-Hyun Lee, Dun-Sheng Yang, Chris N. Goulbourne, Eunju Im, Philip Stavrides, Anna Pensalfini, Han Chan, Cedric Bouchet-Marquis, Cynthia Bleiwas, Martin J. Berg, Chunfeng Huo, James Peddy, Monika Pawlik, Efrat Levy, Mala Rao, Mathias Staufenbiel, Ralph A. Nixon
Publikováno v:
Nature Neuroscience. 25:688-701
Autophagy is markedly impaired in Alzheimer’s disease (AD). Here we reveal unique autophagy dysregulation within neurons in five AD mouse models in vivo and identify its basis using a neuron-specific transgenic mRFP-eGFP-LC3 probe of autophagy and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5bc48852728fc53fbe780572287d2d
https://doi.org/10.1038/s41593-022-01084-8
https://doi.org/10.1038/s41593-022-01084-8
Cocaine Modulates the Neuronal Endosomal System and Extracellular Vesicles in a Sex-Dependent Manner
Autor:
Bryana R. Barreto, Pasquale D’Acunzo, Jonathan M. Ungania, Sasmita Das, Audrey Hashim, Chris N. Goulbourne, Stefanie Canals-Baker, Mitsuo Saito, Mariko Saito, Henry Sershen, Efrat Levy
Publikováno v:
Neurochemical Research. 47:2263-2277
In multiple neurodevelopmental and neurodegenerative disorders, endosomal changes correlate with changes in exosomes. We examined this linkage in the brain of mice that received cocaine injections for two weeks starting at 2.5 months of age. Cocaine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47a04f8187f1b211df0d22945426f2b
https://doi.org/10.1007/s11064-022-03612-1
https://doi.org/10.1007/s11064-022-03612-1