Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1

Autor: Zuzana Bencokova, Chris McGurk, Ester M. Hammond, Isabel M. Pires

Publikováno v: Pires, I M, Bencokova, Z, McGurk, C & Hammond, E M 2010, ' Exposure to acute hypoxia induces a transient DNA damage response which includes Chk1 and TLK1 ', Cell cycle (Georgetown, Tex.), vol. 9, no. 13, pp. 2502-2507 . https://doi.org/10.4161/cc.9.13.12059

Severe hypoxia has been demonstrated to induce a replication arrest which is associated with decreased levels of nucleotides. Chk1 is rapidly phosphorylated in response to severe hypoxia and in turn deactivates TLK1 through phosphorylation. Loss of C

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https://doi.org/10.4161/cc.9.13.12059