Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Chris M. McGinley"'
Publikováno v:
Synlett. :211-214
The use of vitamin B 1 2 for synthetic organic transformations has been extensively studied. Herein, we report the intramolecular cyclization reaction of a series of arylalkene substrates catalyzed by vitamin B 1 2 . Thesereactions proceed in good yi
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 49:545-558
The synthesis of arachidonic acid derivatives containing site-specifically incorporated deuterium atoms and also a remote tritium label are described. Deuterium incorporation at the C11 and/or C15 position was achieved using Wittig chemistry, while t
Autor:
Wilfred A. van der Donk, Justin Shey, Kevin M. McCauley, Chris M. McGinley, Brian T. Young, Anthony S. Dearth
Publikováno v:
ChemInform. 33
In the presence of catalytic vitamin B(12) and a reducing agent such as Ti(III)citrate or Zn, arylalkenes are dimerized with unusual regioselectivity forming a carbon [bond] carbon bond between the benzylic carbons of each coupling partner. Dimerizat
Publikováno v:
Organicbiomolecular chemistry. 6(22)
Lipoxygenases catalyse the oxidation of polyunsaturated fatty acids and have been invoked in many diseases including cancer, atherosclerosis and Alzheimer's disease. Currently, no X-ray structures are available with substrate or substrate analogues b
Autor:
Theodore R. Holman, Wilfred A. van der Donk, Cyril Jacquot, Aaron T. Wecksler, Chris M. McGinley, Erika N. Segraves
Publikováno v:
Biochemistry. 47(27)
Lipoxygenases (LOs) catalyze lipid peroxidation and have been implicated in a number of human diseases connected to oxidative stress and inflammation. These enzymes have also attracted considerable attention due to large kinetic isotope effects (30
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(14)
The mechanism by which prostaglandin synthase converts arachidonic acid to prostaglandin G(2), creating five new chiral centers in the process, is still incompletely understood. The first radical intermediate has been characterized by EPR spectroscop
Publikováno v:
ChemInform. 37
The use of vitamin B 1 2 for synthetic organic transformations has been extensively studied. Herein, we report the intramolecular cyclization reaction of a series of arylalkene substrates catalyzed by vitamin B 1 2 . Thesereactions proceed in good yi
Autor:
W. A. van der Donk, Wen Liu, Richard J. Kulmacz, Lee-Ho Wang, Y. Hayashi, P. Fabian, Chris M. McGinley
Publikováno v:
Plant physiology and biochemistry : PPB. 44(5-6)
Plant alpha dioxygenases (PADOX) convert fatty acids to 2-hydroperoxy products that are important in plant signaling pathways. The PADOX amino-terminal domain is distinct from that in other myeloperoxidase-family hemoproteins, and the positional spec
Publikováno v:
Organic letters. 6(3)
[structure: see text] Prostaglandin H synthase catalyzes the first committed step in the biosynthesis of prostaglandins and thromboxane. Herein we report the synthesis of four site-specifically labeled arachidonic acids for investigation of the radic
Autor:
Brian T. Young, Anthony S. Dearth, Chris M. McGinley, Wilfred A. van der Donk, Kevin M. McCauley, Justin Shey
Publikováno v:
The Journal of organic chemistry. 67(3)
In the presence of catalytic vitamin B(12) and a reducing agent such as Ti(III)citrate or Zn, arylalkenes are dimerized with unusual regioselectivity forming a carbon [bond] carbon bond between the benzylic carbons of each coupling partner. Dimerizat