Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Chris M. Farnet"'
Autor:
Ming Ma, Hui Jiang, Jeremy R. Lohman, Jeong-Woo Seo, Chris M. Farnet, Chunying Yang, Emmanuel Zazopoulos, John L. Cleveland, Jianhua Ju, Si-Kyu Lim, Thomas Kwong, Ben Shen
Publikováno v:
Biochemistry
Lactimidomycin (LTM, 1) and iso-migrastatin (iso-MGS, 2) belong to the glutarimide-containing polyketide family of natural products. We previously cloned and characterized the mgs biosynthetic gene cluster from Streptomyces platensis NRRL 18993. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8e910f034bbc4680c667a8baf6d770f
http://europepmc.org/articles/PMC4270375
http://europepmc.org/articles/PMC4270375
Autor:
Anne Marie Alarco, Dan Sørensen, Arjun H. Banskota, Emmanuel Zazopoulos, Mahmood Piraee, Christophe Mellon, Chris M. Farnet, Henriette Gourdeau, Ashraf S. Ibrahim, Mustapha Aouidate, James B. McAlpine, Pierre Falardeau
Publikováno v:
The Journal of Antibiotics. 62:565-570
The deposited strain of the hazimicin producer, Micromonospora echinospora ssp. challisensis NRRL 12255 has considerable biosynthetic capabilities as revealed by genome scanning. Among these is a locus containing both type I and type II PKS genes. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f79a0d9e16cc2bed0225f57ac9043aaf
https://doi.org/10.1038/ja.2009.77
https://doi.org/10.1038/ja.2009.77
Autor:
Mustapha Aouidate, Ashraf S. Ibrahim, Dan Sørensen, Chris M. Farnet, James B. McAlpine, Emmanuel Zazopoulos, Arjun H. Banskota, Anne Marie Alarco, Mahmood Piraee
Publikováno v:
The Journal of Antibiotics. 59:533-542
Genomic analyses of Amycolatopsis orientalis ATCC 43491 strain, deposited as a vancomycin producer, revealed the presence of genetic loci for the production of at least 10 secondary metabolites other than vancomycin. One of these gene clusters, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e185de53d27a0e5d02b17ba01dc81b4f
https://doi.org/10.1038/ja.2006.74
https://doi.org/10.1038/ja.2006.74
Autor:
Alfredo Staffa, Ben Shen, Koichi Nonaka, Wen Liu, Jon S. Thorson, Joachim Ahlert, Kexue Huang, Chris M. Farnet, Emmanuel Zazopoulos, Brian O. Bachmann
Publikováno v:
Nature Biotechnology. 21:187-190
Genome analysis of actinomycetes has revealed the presence of numerous cryptic gene clusters encoding putative natural products. These loci remain dormant until appropriate chemical or physical signals induce their expression. Here we demonstrate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbb4a91ea3d26e2c74f2584faa44ccd5
https://doi.org/10.1038/nbt784
https://doi.org/10.1038/nbt784
Autor:
Peter J. Felock, Russell B. Lingham, Carol Blau, Chris M. Farnet, Daria J. Hazuda, Abigail Wolfe, Frederic D. Bushman, M. D. Williams, Jeffrey Hastings, Bernali Pramanik, Keith C. Silverman, Sheo B. Singh, Michael A. Goetz
Publikováno v:
Scopus-Elsevier
We have identified a series of novel inhibitors of human immunodeficiency virus type 1 (HIV-1) integrase by randomly screening natural product extracts using an in vitro biochemical assay designed to identify inhibitors of integrase-catalysed strand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31c30864f90dabed4558c2608d54a051
https://doi.org/10.1177/095632029901000202
https://doi.org/10.1177/095632029901000202
Publikováno v:
Journal of Virology. 72:2125-2131
We have explored the requirements for host proteins in the integration of Moloney murine leukemia virus (MoMuLV) cDNA in vitro. Following infection, it is possible to lyse cells and obtain preintegration complexes (PICs) capable of integrating the Mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfb2edd3dd3085842894490697a2bc6a
https://doi.org/10.1128/jvi.72.3.2125-2131.1998
https://doi.org/10.1128/jvi.72.3.2125-2131.1998
Publikováno v:
Journal of Virology. 71:5382-5390
We have investigated the organization and function of human immunodeficiency virus type 1 (HIV-1) preintegration complexes (PICs), the large nucleoprotein particles that carry out cDNA integration in vivo. PICs can be isolated from HIV-1-infected cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cb6fe733d1ddcaaaf323e5ad6d775b1
https://doi.org/10.1128/jvi.71.7.5382-5390.1997
https://doi.org/10.1128/jvi.71.7.5382-5390.1997
Autor:
Chris M. Farnet, Frederic D. Bushman
Publikováno v:
AIDS. 10:S3-12
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::082de4b578b709b3e79a5918e187d536
https://doi.org/10.1097/00002030-199601001-00002
https://doi.org/10.1097/00002030-199601001-00002
Publikováno v:
Biochemical and Biophysical Research Communications. 215:987-993
DNA end-joining is a central feature of several DNA recombination processes. A DNA end-joining activity present in extracts prepared from cells of the human SupT1 lymphocyte cell line was characterised. Joining of blunt ends and ends having complemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6f10bd9ea6a40cbda6a46580059080
https://doi.org/10.1006/bbrc.1995.2561
https://doi.org/10.1006/bbrc.1995.2561
Publikováno v:
Journal of Virology. 68:8401-8405
A previous genetic analysis of the human immunodeficiency virus type 1 integrase protein failed to identify single amino acid substitutions that only block the integration of viral DNA (C.-G. Shin, B. Taddeo, W.A. Haseltine, and C.M. Farnet, J. Virol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0050e6bba7c2eede59327938b51d69c8
https://doi.org/10.1128/jvi.68.12.8401-8405.1994
https://doi.org/10.1128/jvi.68.12.8401-8405.1994