Spatial differences in the presence of FOXP3+ and GranzymeB+ T cells between the intra- and extravascular compartments in renal allograft vasculopathy.

Autor: Onno J de Boer, Peter Teeling, Marcel Jansen, Hanneke Ploegmakers, Chris M van der Loos, J Alain Kummer, Sandrine Florquin, Allard C van der Wal

Publikováno v: PLoS ONE, Vol 6, Iss 4, p e18656 (2011)

BACKGROUND: Allograft vasculopathy (AV) and native atherosclerosis (NA) share the presence of a T-cell mediated inflammatory response, but differ in overall plaque morphology and growth rate. We studied the distribution and frequency of regulatory- a

Externí odkaz: https://doaj.org/article/e69c4998a01e44a8b00f4248f468947e

Allele-specific regulation of matrix metalloproteinase-3 gene by transcription factor NFkappaB.

Autor: Veronika Souslova, Paul A Townsend, Jelena Mann, Chris M van der Loos, Anna Motterle, Fulvio D'Acquisto, Derek A Mann, Shu Ye

Publikováno v: PLoS ONE, Vol 5, Iss 3, p e9902 (2010)

Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the M

Externí odkaz: https://doaj.org/article/f2b8d3a6e3994059a806ef88ada8a1f6

Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis.

Autor: Pieter C M Res, Gamze Piskin, Onno J de Boer, Chris M van der Loos, Peter Teeling, Jan D Bos, Marcel B M Teunissen

Publikováno v: PLoS ONE, Vol 5, Iss 11, p e14108 (2010)

BACKGROUND: Although recent studies indicate a crucial role for IL-17A and IL-22 producing T cells in the pathogenesis of psoriasis, limited information is available on their frequency and heterogeneity and their distribution in skin in situ. METHODO

Externí odkaz: https://doaj.org/article/a4d5d004d3c24f98915139efa9c423ed

A rare variant in MCF2L identified using exclusion linkage in a pedigree with premature atherosclerosis

Autor: Stephanie Maiwald, Suthesh Sivapalaratnam, G. Kees Hovingh, Geesje M. Dallinga-Thie, M. Mahdi Motazacker, John J.P. Kastelein, Jaap D. van Buul, Allard C. van der Wal, Julian C. van Capelleveen, Chris M. van der Loos, Mieke D. Trip, Willem H. Ouwehand

Publikováno v: European journal of human genetics, 24(1), 86-91. Nature Publishing Group

Cardiovascular disease (CVD) is a major cause of death in Western societies. CVD risk is largely genetically determined. The molecular pathology is, however, not elucidated in a large number of families suffering from CVD. We applied exclusion linkag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::031a34b79bc27f22e0ba8796ec5c57b1
https://doi.org/10.1038/ejhg.2015.70

Imbalance between pulmonary angiotensin-converting enzyme and angiotensin-converting enzyme 2 activity in acute respiratory distress syndrome

Autor: Chris M. van der Loos, Albert P. Bos, René Lutter, Barbara Dierdorp, Harry van Goor, Tamara Dekker, Reinout A. Bem, Elske van den Berg, Job B. M. van Woensel, Roelie M. Wösten-van Asperen, Jelena Kamilic, Martijn Bruijn

Publikováno v: Pediatric critical care medicine, 14(9), e438-e441. Lippincott Williams and Wilkins
Pediatric critical care medicine, 14(9), E438-E441. LIPPINCOTT WILLIAMS & WILKINS

Objective: Angiotensin-converting enzyme and its effector peptide angiotensin II have been implicated in the pathogenesis of acute respiratory distress syndrome. Recently, angiotensin-converting enzyme 2 was identified as the counter-regulatory enzym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546a9f8042cd726b07ce0f26bd8ca315
https://doi.org/10.1097/pcc.0b013e3182a55735