Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Chris M Hempel"'
Autor:
Chris M Hempel, Michael Sivula, Jonathan M Levenson, David M Rose, Bing Li, Ana C Sirianni, Eva Xia, Timothy A Ryan, David J Gerber, Jeffrey R Cottrell
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e25999 (2011)
Unbiased, high-throughput screening has proven invaluable for dissecting complex biological processes. Application of this general approach to synaptic function would have a major impact on neuroscience research and drug discovery. However, existing
Externí odkaz:
https://doaj.org/article/fdf71dfa2015421391b3c8b8a3106f35
Autor:
Owen B. McManus, Vivian Hecht, Violeta Yu, Chris M Hempel, Graham T. Dempsey, Ryan J. Babcock, Michael Jarosh, Joseph G. McGivern, Hongkang Zhang, Kevin Dong, Bryan D. Moyer, Christopher A. Werley
Publikováno v:
SLAS Discovery. 25:434-446
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors requires a reliable, scalable,
Autor:
Hongkang, Zhang, Bryan D, Moyer, Violeta, Yu, Joseph G, McGivern, Michael, Jarosh, Christopher A, Werley, Vivian C, Hecht, Ryan J, Babcock, Kevin, Dong, Graham T, Dempsey, Owen B, McManus, Chris M, Hempel
Publikováno v:
SLAS discovery : advancing life sciences RD. 25(5)
The voltage-gated sodium channel Nav1.7 is a genetically validated target for pain; pharmacological blockers are promising as a new class of nonaddictive therapeutics. The search for Nav1.7 subtype selective inhibitors requires a reliable, scalable,
Publikováno v:
Drug Discovery Today: Technologies. 23:17-25
There is a pressing need for new and more effective treatments for central nervous system (CNS) disorders. A large body of evidence now suggests that alterations in synaptic transmission and neuronal excitability represent underlying factors for many
Autor:
Chris M. Hempel, Celine C. Steinmetz, Sacha B. Nelson, Mary E. Lambo, Heather Lin, Yasuyuki Shima, Benjamin W. Okaty, Ken Sugino, Gina G. Turrigiano, Anne Joseph, Michael Rutlin, Vedakumar Tatavarty, Suzanne Paradis
Publikováno v:
Cell Reports, Vol 16, Iss 10, Pp 2711-2722 (2016)
Elsevier
Elsevier
SummarySynaptic scaling is a form of homeostatic plasticity driven by transcription-dependent changes in AMPA-type glutamate receptor (AMPAR) trafficking. To uncover the pathways involved, we performed a cell-type-specific screen for transcripts pers
Autor:
Benjamin W. Okaty, Saori Kato, Hannah A. Arnson, Vardhan S. Dani, Sacha B. Nelson, Ken Sugino, Chris M. Hempel
Publikováno v:
Journal of Neuroscience. 34:12877-12883
Mutations in methyl-CpG-binding protein 2 (MeCP2) cause Rett syndrome and related autism spectrum disorders (Amir et al., 1999). MeCP2 is believed to be required for proper regulation of brain gene expression, but prior microarray studies in Mecp2 kn
Autor:
Sacha B. Nelson, Praveen Taneja, Chris M. Hempel, Yasuyuki Shima, Carlos Lois, Masami Shima, James B. Bullis, Sonam Mehta, Ken Sugino
Publikováno v:
eLife
eLife, Vol 5 (2016)
eLife, Vol 5 (2016)
There is a continuing need for driver strains to enable cell-type-specific manipulation in the nervous system. Each cell type expresses a unique set of genes, and recapitulating expression of marker genes by BAC transgenesis or knock-in has generated
Publikováno v:
The Journal of Neuroscience. 29:7040-7052
Fast-spiking (FS) interneurons are important elements of neocortical circuitry that constitute the primary source of synaptic inhibition in adult cortex and impart temporal organization on ongoing cortical activity. The highly specialized intrinsic m
Autor:
David M. Rose, Pascal Laeng, Ryan J. Babcock, Margaret Levin, Karen A. Heindl, Timothy A. Ryan, Helen E. Gibson, Bing Li, Kjesten A. Wiig, Jonathan M. Levenson, Sung Hyun Kim, David J. Gerber, Chris M. Hempel, Jeffrey R. Cottrell, Crystle J. Ashford, Kristen A. Richardson, Michael Sivula
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(27)
Working memory is an essential component of higher cognitive function, and its impairment is a core symptom of multiple CNS disorders, including schizophrenia. Neuronal mechanisms supporting working memory under normal conditions have been described