Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Chris Luft"'
Autor:
Stefan W Metz, Ashlie Thomas, Alex Brackbill, Yi Xianwen, Michele Stone, Katie Horvath, Michael J Miley, Chris Luft, Joseph M DeSimone, Shaomin Tian, Aravinda M de Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 9, p e0006793 (2018)
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies in
Externí odkaz:
https://doaj.org/article/a436f753500142288d12edd9e04f8822
Autor:
Michelle Stone, Aravinda M. de Silva, Xianwen Yi, Michael J. Miley, Stefan W. Metz, Gabriel Hoekstra, Joseph M. DeSimone, Chris Luft, Katie Horvath, Shaomin Tian
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 10, p e0005071 (2016)
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
PLOS Neglected Tropical Diseases
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever. The virus is endemic in over 120 countries, causing over 350 million infections per year. Dengue vaccine development is challenging because of the need to induce
Autor:
J. Chris Luft, James E. Bear, Marc P. Kai, Kevin P. Herlihy, Kevin G. Reuter, Joseph M. DeSimone, Jillian L. Perry, Mary E. Napier, Stephen W. Jones
Publikováno v:
Nano Letters. 12:5304-5310
In this account, we varied PEGylation density on the surface of hydrogel PRINT nanoparticles and systematically observed the effects on protein adsorption, macrophage uptake, and circulation time. Interestingly, the density of PEGylation necessary to
Autor:
Michele Stone, Ashlie Thomas, Aravinda M. de Silva, Katie Horvath, Chris Luft, Stefan W. Metz, Alex Brackbill, Yi Xianwen, Shaomin Tian, Joseph M. DeSimone, Michael J. Miley
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 9, p e0006793 (2018)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need to induce protection against four antigenically distinct DENV serotypes. Recent studies in
Autor:
Mohammad N. R. Jajja, Colleen Stack, William C. Zamboni, Adrian T. O'Neill, Lissett R. Bickford, Nabeel Hyder, Christopher R. Brooks, Richard S. Stack, James D. Byrne, David B. Darr, Ryan E. Little, Kyle Wagner, William Lee, Andrew Z. Wang, J. Chris Luft, Richard A. Moffitt, Meredith Nelson, Amanda W. Keeler, Joel E. Tepper, Carey K. Anders, Allison M. Deal, Jen Jen Yeh, Joseph M. DeSimone, Mary E. Napier
Publikováno v:
Science translational medicine. 7(273)
Parenteral and oral routes have been the traditional methods of administering cytotoxic agents to cancer patients. Unfortunately, the maximum potential effect of these cytotoxic agents has been limited because of systemic toxicity and poor tumor perf
Autor:
Kevin G. Reuter, Charles J. Bowerman, Marc P. Kai, J. Chris Luft, Jillian L. Perry, Joseph M. DeSimone
Publikováno v:
Cancer Treatment and Research ISBN: 9783319165547
Nanoparticle properties such as size, shape, deformability, and surface chemistry all play a role in nanomedicine drug delivery in cancer. While many studies address the behavior of particle systems in a biological setting, revealing how these proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8b73e43ffabcc3ca463222e7a833eca
https://doi.org/10.1007/978-3-319-16555-4_12
https://doi.org/10.1007/978-3-319-16555-4_12
Autor:
J. Chris Luft, Mary E. Napier, Matthew C. Parrott, Joseph M. DeSimone, Mathew C. Finniss, Anuradha Gullapalli, Ashish A. Pandya
Publikováno v:
Journal of the American Chemical Society. 134(18)
Asymmetric bifunctional silyl ether (ABS) prodrugs of chemotherapeutics were synthesized and incorporated within 200 nm × 200 nm particles. ABS prodrugs of gemcitabine were selected as model compounds because of the difficulty to encapsulate a water
Autor:
Steven A. Lommel, Ray Antonelli, Chris Luft, Stefan Franzen, Dustin M. Lockney, Richard N. Guenther, Lina Loo, Mei Hu, Jennifer A. Clark, K. Wesley Overton
Publikováno v:
Bioconjugate chemistry. 22(1)
Multifunctional nanoparticles hold promise as the next generation of therapeutic delivery and imaging agents. Nanoparticles comprising many types of materials are being tested for this purpose, including plant viral capsids. It has been found that Re
Autor:
Mary E. Napier, John H. Fain, Joseph M. DeSimone, James D. Byrne, J. Chris Luft, Matthew C. Parrott
Responsive polymeric biomaterials can be triggered to degrade using localized environments found in vivo. A limited number of biomaterials provide precise control over the rate of degradation and the release rate of entrapped cargo and yield a materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e9dbec340f68d83764ef14a8de64d9
Autor:
Luke E. Roode, Jillian L. Perry, James E. Bear, J. Chris Luft, Joseph M. DeSimone, Ian J. Davis, Tao Bo
Publikováno v:
Cancer Research. 74:5401-5401
The assessment of nanoparticle accumulation in tumors and other organs uses a whole organ-based approach. These techniques, however, neglect the complex composition of tumors which multiple types of cells other than cancer cells(e.g. endothelial cell