Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Chris Limberakis"'
Autor:
Jordan M. Mattheisen, Chris Limberakis, Roger B. Ruggeri, Matthew S. Dowling, Christopher W. am Ende, Emilie Ceraudo, Thomas Huber, Christopher L. McClendon, Thomas P. Sakmar
Publikováno v:
Journal of the American Chemical Society. 145:11173-11184
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cc5b00c6a565fcfee5f02177fdc5ebb
https://doi.org/10.1021/jacs.3c00972
https://doi.org/10.1021/jacs.3c00972
Autor:
Aaron Baldwin, Shawn Cabral, Kris N. Jones, Jeffrey T. Kohrt, Chris Limberakis, Yiyang Liu, Javier Magano, Sebastien Monfette, Asaad Nematalla, Sami Ovaska, David W. Piotrowski, Jared L. Piper, Jeffrey W. Raggon, Benjamin A. Thuma, Liuqing Wei
Publikováno v:
Organic Process Research & Development. 27:854-865
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b446554282a8d998077c9e50879f0def
https://doi.org/10.1021/acs.oprd.2c00351
https://doi.org/10.1021/acs.oprd.2c00351
Searching for reaction in organic synthesis has been made much easier in the current age of computer databases. However, the dilemma now is which procedure one selects among the ocean of choices. Especially for novices in the laboratory, it becomes a
Autor:
Roberto R. Gil, Chris Limberakis, Kathleen A. Farley, Ricardo Lira, Justin Bellenger, Ye Che, Martin R. M. Koos, Leandro F. Gil‐Silva, Reto Horst
Publikováno v:
Angewandte Chemie International Edition. 60:26314-26319
Determination of the solution conformation of both small organic molecules and peptides in water remains a substantial hurdle in using NMR solution conformations to guide drug design due to the lack of easy to use alignment media. Herein we report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52cedf9cc2b534ba7eb6767034caf793
https://doi.org/10.1002/anie.202106794
https://doi.org/10.1002/anie.202106794
Autor:
David A. Griffith, David J. Edmonds, Jean-Philippe Fortin, Amit S. Kalgutkar, J. Brent Kuzmiski, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Clare Buckeridge, John M. Curto, David R. Derksen, João M. Dias, Matthew C. Griffor, Seungil Han, V. Margaret Jackson, Margaret S. Landis, Daniel Lettiere, Chris Limberakis, Yuhang Liu, Alan M. Mathiowetz, Jayesh C. Patel, David W. Piotrowski, David A. Price, Roger B. Ruggeri, David A. Tess
Publikováno v:
Journal of medicinal chemistry. 65(12)
Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited because they require injection. Herein, we describe the discovery of the orally bioavailable, small-molecule, GLP-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff991134db369ff3aa7ceaecc2f6263e
https://pubmed.ncbi.nlm.nih.gov/35647711
https://pubmed.ncbi.nlm.nih.gov/35647711
Autor:
Ariamala Gopalsamy, Ann E. Aulabaugh, Amey Barakat, Kevin C. Beaumont, Shawn Cabral, Daniel P. Canterbury, Agustin Casimiro-Garcia, Jeanne S. Chang, Ming Z. Chen, Chulho Choi, Robert L. Dow, Olugbeminiyi O. Fadeyi, Xidong Feng, Scott P. France, Roger M. Howard, Jay M. Janz, Jayasankar Jasti, Reema Jasuja, Lyn H. Jones, Amanda King-Ahmad, Kelly M. Knee, Jeffrey T. Kohrt, Chris Limberakis, Spiros Liras, Carlos A. Martinez, Kim F. McClure, Arjun Narayanan, Jatin Narula, Jonathan J. Novak, Thomas N. O’Connell, Mihir D. Parikh, David W. Piotrowski, Olga Plotnikova, Ralph P. Robinson, Parag V. Sahasrabudhe, Raman Sharma, Benjamin A. Thuma, Dipy Vasa, Liuqing Wei, A. Zane Wenzel, Jane M. Withka, Jun Xiao, Hatice G. Yayla
Publikováno v:
Journal of Medicinal Chemistry. 64:326-342
Sickle cell disease (SCD) is a genetic disorder caused by a single point mutation (β6 Glu → Val) on the β-chain of adult hemoglobin (HbA) that results in sickled hemoglobin (HbS). In the deoxygenated state, polymerization of HbS leads to sickling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30fb3aa72d831f7f375af97473787b3a
https://doi.org/10.1021/acs.jmedchem.0c01518
https://doi.org/10.1021/acs.jmedchem.0c01518
Autor:
Chris Limberakis, Allyn T. Londregan, Steven B. Coffey, Gary Erik Aspnes, Janice A. Brown, Kevin D. Hesp, Rhys M. Jones, Elnaz Menhaji-Klotz, Esther C.Y. Lee, Markus Boehm
Publikováno v:
Bioorganicmedicinal chemistry letters. 50
The atypical chemokine receptor C-X-C chemokine receptor type 7 (CXCR7) is an attractive therapeutic target for a variety of cardiac and immunological diseases. As a strategy to mitigate known risks associated with the development of higher molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::814f75791497d041702db0bd1f7ff5db
https://pubmed.ncbi.nlm.nih.gov/34400299
https://pubmed.ncbi.nlm.nih.gov/34400299
Autor:
Jiangli Yan, Armando Navarro-Vázquez, Ye Che, Veerabahu Shanmugasundaram, Dennis P. Anderson, Roberto R. Gil, Chris Limberakis, Michael J. Shapiro, Kathleen A. Farley
Publikováno v:
The Journal of Organic Chemistry. 84:4803-4813
Cyclic peptides have long tantalized drug designers with their potential ability to combine the best attributes of antibodies and small molecules. An ideal cyclic peptide drug candidate would be able to recognize a protein surface like an antibody wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e76e08fa6c98f7d64a61404810aa89be
https://doi.org/10.1021/acs.joc.8b02811
https://doi.org/10.1021/acs.joc.8b02811
Autor:
J. Brent Kuzmiski, João M. Dias, Seungil Han, Chris Limberakis, David Price, David J. Edmonds, John M. Curto, Amit S. Kalgutkar, Daniel J. Lettiere, David A. Tess, Clare Buckeridge, Matthew C. Griffor, David R. Derksen, Alan M. Mathiowetz, Roger B. Ruggeri, Paula M. Loria, Aditi R. Saxena, Scott W. Bagley, Yuhang Liu, Margaret S. Landis, David W. Piotrowski, V. Margaret Jackson, David A. Griffith, Jean-Phillipe Fortin
Peptide agonists of the glucagon-like peptide-1 receptor (GLP-1R) have revolutionized diabetes therapy, but their use has been limited by the requirement for injection. Here we describe the first effective, orally bioavailable small molecule GLP-1R a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::064b771366df377937229b83ffb7a9bf
https://doi.org/10.1101/2020.09.29.319483
https://doi.org/10.1101/2020.09.29.319483