Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Chris Krueger A"'
Autor:
Chris Krueger
Publikováno v:
Bolivian Studies Journal, Vol 23, Iss 0, Pp 151-187 (2018)
This piece works off the contents of Larry Heilman´s book also based largely on his personal experience of decades in USAID and subsequent research over at least ten years. The first part follows the chronology of his work, that covers some 70 years
Externí odkaz:
https://doaj.org/article/7445db77c3f1437da70531cbe1fa56c1
Autor:
Kathy Sarris, Philip J. Hajduk, Ihle David C, Diana L. Donnelly-Roberts, Arthur Gomtsyan, Christian Goess, David B. Duignan, Danying Song, Chaohong Sun, Andrea Mcclure, Adrian D. Hobson, Robert H. Stoffel, Anil Vasudevan, John A. Mankovich, Sanjay C. Panchal, A. Chris Krueger, Steven L. Swann, Kenneth M. Comess, Andrew M. Petros, Wilson Noel S, Jill M. Wetter, Paul G. Richardson, Kenton L. Longenecker, Paul M. Jung, Vincent S. Stoll, Amanda W. Dombrowski, Suzanne Mathieu, Justin D. Dietrich, Philip B. Cox
Publikováno v:
Journal of Medicinal Chemistry. 64:417-429
Tumor necrosis factor α (TNFα) is a soluble cytokine that is directly involved in systemic inflammation through the regulation of the intracellular NF-κB and MAPK signaling pathways. The development of biologic drugs that inhibit TNFα has led to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72dbe3ede703ddd1435f27709b6c8281
https://doi.org/10.1021/acs.jmedchem.0c01280
https://doi.org/10.1021/acs.jmedchem.0c01280
Autor:
Chris Krueger
Publikováno v:
Bolivian Studies Journal, Vol 18, Iss 0, Pp 229-241 (2012)
This work approaches the complex relation between North American institutions dedicated to the production of knowledge on Bolivia and its homologous Bolivians, emphasizing the fact that nowadays in Bolivia not only an immense intellectual wealth tota
Externí odkaz:
https://doaj.org/article/d6080d2ac75b470cbb4abb532acba51d
Autor:
Randolph, John T., Li, Tongmei, Chris Krueger, A., Heyman, Howard R., Chen, Hui-Ju, Bow, Daniel A.J., Van Handel, Cecilia, Peterkin, Vincent, Carr, Robert A., Stolarik, DeAnne, Dekhtyar, Tatyana, Irvin, Michelle, Krishnan, Preethi, Wagner, Rolf, DeGoey, David A.
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 April 2020 30(7)
Autor:
Emily O. Dumas, Kent D. Stewart, Michael D. Tufano, Jill Beyer, Neeta S. Panchal, Dachun Liu, Warren M. Kati, Lisa E. Hernandez, Todd W. Rockway, John K. Pratt, John T. Randolph, Clarence J. Maring, David W A Beno, G. Koev, Donner Pamela L, Yaya Liu, Motter Christopher E, Kenton L. Longenecker, Lynn Colletti, Rolf Wagner, Rubina Mondal, A. Chris Krueger, Hock B. Lim, Akhteruzzaman Molla
Publikováno v:
Journal of Medicinal Chemistry. 61:1153-1163
ABT-072 is a non-nucleoside HCV NS5B polymerase inhibitor that was discovered as part of a program to identify new direct-acting antivirals (DAAs) for the treatment of HCV infection. This compound was identified during a medicinal chemistry effort to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caf57ddf93589bc577ed9ee07cab1807
https://doi.org/10.1021/acs.jmedchem.7b01630
https://doi.org/10.1021/acs.jmedchem.7b01630
Autor:
Preethi Krishnan, Rodger F. Henry, Christopher C. Marvin, Tatyana Dekhtyar, Rolf Wagner, John T. Randolph, A. Chris Krueger, David A. Degoey, Vincent Peterkin, Michelle Irvin, Geoff T. Halvorsen, Jason P. Shanley, Heyman Howard R, Eric A. Voight, Robert A. Carr, Cecilia Van Handel, Tongmei Li, Brian S. Brown, Daniel A.J. Bow, Hui-Ju Chen, DeAnne Stolarik
Publikováno v:
Bioorganicmedicinal chemistry. 28(1)
Download : Download high-res image (149KB) Download : Download full-size image Hepatitis C virus (HCV) nucleoside inhibitors have been a key focus of nearly 2 decades of HCV drug research due to a high barrier to drug resistance and pan-genotypic act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b00db3e130eced12af4080c2bb37216
https://pubmed.ncbi.nlm.nih.gov/31740203
https://pubmed.ncbi.nlm.nih.gov/31740203
Autor:
John T. Randolph, Vincent Peterkin, Robert A. Carr, David A. Degoey, Tongmei Li, Daniel A.J. Bow, Hui-Ju Chen, Preethi Krishnan, DeAnne Stolarik, Rolf Wagner, Cecilia Van Handel, Michelle Irvin, A. Chris Krueger, Heyman Howard R, Tatyana Dekhtyar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126986
Our HCV research program investigated novel 2′-dihalogenated nucleoside HCV polymerase inhibitors and identified compound 1, a 5′-phosphoramidate prodrug of 2′-deoxy-2′-α-bromo-β-chloro uridine. Although 1 had a favorable in vitro activity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca24f2cfcd4eecb33ca13fd5216c0e7
https://doi.org/10.1016/j.bmcl.2020.126986
https://doi.org/10.1016/j.bmcl.2020.126986
Autor:
Ryan G. Keddy, Warren M. Kati, Tami Pilot-Matias, Nelson Lissa T, DeAnne Stolarik, Tatyana Dekhtyar, Rubina Mondal, Thomas Reisch, A. Chris Krueger, Hutchinson Douglas K, Donner Pamela L, John T. Randolph, Wenqing Gao, David A. Betebenner, Clarence J. Maring, Preethi Krishnan, Neeta S. Panchal, Christine A. Collins, Todd W. Rockway, Yi Gao, Teresa I. Ng, David W A Beno, John K. Pratt, Dachun Liu, Sachin V. Patel, Charles A. Flentge, Mark A. Matulenko, Rolf Wagner
Publikováno v:
Journal of medicinal chemistry. 61(9)
Curative interferon and ribavirin sparing treatments for hepatitis C virus (HCV)-infected patients require a combination of mechanistically orthogonal direct acting antivirals. A shared component of these treatments is usually an HCV NS5A inhibitor.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0ea7f78cae0082405f10eb7a8974af
https://pubmed.ncbi.nlm.nih.gov/29653491
https://pubmed.ncbi.nlm.nih.gov/29653491
Autor:
Kenton L. Longenecker, G. Koev, A. Chris Krueger, Jill Beyer, Dachun Liu, John T. Randolph, Kent D. Stewart, Rolf Wagner, Warren M. Kati, Donner Pamela L, David W A Beno, Hutchinson Douglas K, Rubina Mondal, Yaya Liu, Todd W. Rockway, Hock B. Lim, Akhteruzzaman Molla, Clarence J. Maring, Charles A. Flentge, Christopher E. Motter, David A. Degoey
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:3487-3490
The synthesis and structure–activity relationships of a novel aryl uracil series which contains a fused 5,6-bicyclic ring unit for HCV NS5B inhibition is described. Several analogs display replicon cell culture potencies in the low nanomolar range
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f742a15f796c0f4b5fec021cc5a862f
https://doi.org/10.1016/j.bmcl.2013.04.057
https://doi.org/10.1016/j.bmcl.2013.04.057
Autor:
Chris Krueger
Publikováno v:
Bolivian Studies Journal, Vol 18, Iss 0, Pp 229-241 (2012)
This work approaches the complex relation between North American institutions dedicated to the production of knowledge on Bolivia and its homologous Bolivians, emphasizing the fact that nowadays in Bolivia not only an immense intellectual wealth tota
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc29aa8fd95b02abc18448964f06e95
https://doi.org/10.5195/bsj.2011.44
https://doi.org/10.5195/bsj.2011.44