Zobrazeno 1 - 10
of 110
pro vyhledávání: '"Chris Kintner"'
Autor:
Ian K Quigley, Chris Kintner
Publikováno v:
PLoS Genetics, Vol 13, Iss 1, p e1006538 (2017)
Cooperative transcription factor binding at cis-regulatory sites in the genome drives robust eukaryotic gene expression, and many such sites must be coordinated to produce coherent transcriptional programs. The transcriptional program leading to moti
Externí odkaz:
https://doaj.org/article/d7861d977a5b495c9f9e1027b1a4a799
Autor:
Dragana Antic, Jennifer L Stubbs, Kaye Suyama, Chris Kintner, Matthew P Scott, Jeffrey D Axelrod
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e8999 (2010)
Left-right asymmetry in vertebrates is initiated in an early embryonic structure called the ventral node in human and mouse, and the gastrocoel roof plate (GRP) in the frog. Within these structures, each epithelial cell bears a single motile cilium,
Externí odkaz:
https://doaj.org/article/143b2750d89c4966930141a8cacb6178
Publikováno v:
Science Advances. 8
Massive centriole amplification during multiciliated cell (MCC) differentiation is a notable example of organelle biogenesis. This process is thought to be enabled by a derived cell cycle state, but the key cell cycle components required for centriol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a77e1412b53e186024118e74753d287
https://doi.org/10.1126/sciadv.abm7538
https://doi.org/10.1126/sciadv.abm7538
Publikováno v:
Cellsdevelopment. 170
Mechanical strain can act as a global cue to orient the core planar cell polarity pathway (Fz-PCP) in developing epithelia, but how strain directs a Fz-PCP vector is not known. Here we use live cell imaging of apical microtubules (MTs) and components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ade04ade9eb62355e31c1439053217
https://pubmed.ncbi.nlm.nih.gov/35561956
https://pubmed.ncbi.nlm.nih.gov/35561956
Autor:
Thomas M. Jessell, Lora B. Sweeney, Jerry H. Yang, Linjing Fang, Jay B. Bikoff, Alina Salamatina, Chris Kintner, Susan Brenner-Morton
Publikováno v:
Neuroscience. 450
Amyotrophic lateral sclerosis (ALS) leads to a loss of specific motor neuron populations in the spinal cord and cortex. Emerging evidence suggests that interneurons may also be affected, but a detailed characterization of interneuron loss and its pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79f8fc04f95a125f123dece9342fa648
https://pubmed.ncbi.nlm.nih.gov/32858144
https://pubmed.ncbi.nlm.nih.gov/32858144
Autor:
Israel, Amirav, Julia, Wallmeier, Niki T, Loges, Tabea, Menchen, Petra, Pennekamp, Huda, Mussaffi, Revital, Abitbul, Avraham, Avital, Lea, Bentur, Gerard W, Dougherty, Elias, Nael, Moran, Lavie, Heike, Olbrich, Claudius, Werner, Chris, Kintner, Heymut, Omran, Ruth, Soferman
Publikováno v:
Human Mutation. 37:396-405
Reduced generation of multiple motile cilia (RGMC) is a novel chronic destructive airway disease within the group of mucociliary clearance disorders with only few cases reported. Mutations in two genes, CCNO and MCIDAS, have been identified as a caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e0994557552a46328c8e1fc910f2a2
https://doi.org/10.1002/humu.22957
https://doi.org/10.1002/humu.22957
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
Multiciliated cells (MCCs) are specialized epithelial cells that project hundreds of motile cilia. To form these cilia, MCCs differentiate by dramatically expanding centriole number, using assembly factors required for centriole duplication during th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df0da85f20c8fcc0b1ec96c5122da47
https://doi.org/10.1038/s41598-018-30791-1
https://doi.org/10.1038/s41598-018-30791-1
Publikováno v:
Current Biology. 25:2774-2784
SummaryEpithelia containing multiciliated cells align beating cilia along a common planar axis specified by the conserved planar cell polarity (PCP) pathway. Specification of the planar axis is also thought to require a long-range cue to align the ax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6457fcd982674a92c6875e14aaa3356
https://doi.org/10.1016/j.cub.2015.09.015
https://doi.org/10.1016/j.cub.2015.09.015
Mechanical Strain Determines Cilia Length, Motility, and Planar Position in the Left-Right Organizer
Publikováno v:
Developmental cell. 45(3)
The Xenopus left-right organizer (LRO) breaks symmetry along the left-right axis of the early embryo by producing and sensing directed ciliary flow as a patterning cue. To carry out this process, the LRO contains different ciliated cell types that va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05a4db79f39a36d0a29912c673e2e74d
https://pubmed.ncbi.nlm.nih.gov/29738704
https://pubmed.ncbi.nlm.nih.gov/29738704
Publikováno v:
Development (Cambridge, England). 144(4)
Multiciliated cell (MCC) differentiation involves extensive organelle biogenesis required to extend hundreds of motile cilia. Key transcriptional regulators known to drive the gene expression required for this organelle biogenesis are activated by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cb18876492fda5e6c3a730612ee7199
https://pubmed.ncbi.nlm.nih.gov/27864379
https://pubmed.ncbi.nlm.nih.gov/27864379