Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Chris Kimberley"'
Autor:
Melissa Barroux, Jacob Househam, Eszter Lakatos, Tahel Ronel, Ann-Marie Baker, Henrike Salié, Max Mossner, Kane Smith, Chris Kimberley, Salpie Nowinski, Alison Berner, Vinaya Gunasri, Marnix Jansen, Giulio Caravagna, Katja Steiger, Julia Slotta-Huspenina, Wilko Weichert, Markus Alberstmeier, Benny Chain, Helmut Friess, Bertram Bengsch, Roland Schmid, Jens Siveke, Michael Quante, Trevor Graham
Locally advanced oesophageal adenocarcinoma (EAC) remains difficult to treat because of common resistance to neoadjuvant therapy and high recurrence rates. The ecological and evolutionary dynamics responsible for treatment failure are incompletely un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23626ec121eaf552ab7c2479aaea43d5
https://doi.org/10.21203/rs.3.rs-2738048/v1
https://doi.org/10.21203/rs.3.rs-2738048/v1
Autor:
Melissa Barroux, Jacob Househam, Eszter Lakatos, Tahel Ronel, Ann-Marie Baker, Henrike Salié, Max Mossner, Kane Smith, Chris Kimberley, Salpie Nowinski, Alison Berner, Vinaya Gunasri, Marnix Jansen, Giulio Caravagna, Julia Slotta-Huspenina, Wilko Weichert, Markus Alberstmeier, Benny Chain, Helmut Friess, Bertram Bengsch, Roland M. Schmid, Jens T. Siveke, Michael Quante, Trevor A. Graham
Publikováno v:
Cancer Research. 83:4539-4539
Introduction: Locally advanced esophageal adenocarcinoma (EAC) remains difficult to treat, and resistance is common. The ecological and evolutionary dynamics responsible for treatment failure are incompletely understood. Aim & Methods: We performed a
Autor:
Timon Heide, Jacob Househam, George D. Cresswell, Inmaculada Spiteri, Claire Lynn, Maximilian Mossner, Chris Kimberley, Javier Fernandez-Mateos, Bingjie Chen, Luis Zapata, Chela James, Iros Barozzi, Ketevan Chkhaidze, Daniel Nichol, Vinaya Gunasri, Alison Berner, Melissa Schmidt, Eszter Lakatos, Ann-Marie Baker, Helena Costa, Miriam Mitchinson, Rocco Piazza, Marnix Jansen, Giulio Caravagna, Daniele Ramazzotti, Darryl Shibata, John Bridgewater, Manuel Rodriguez-Justo, Luca Magnani, Trevor A. Graham, Andrea Sottoriva
Colorectal malignancies are a leading cause of cancer-related death1 and have undergone extensive genomic study2,3. However, DNA mutations alone do not fully explain malignant transformation4–7. Here we investigate the co-evolution of the genome an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c5ce292f9f3a649633e0bd1f4fb0f20
https://hdl.handle.net/11368/3033100
https://hdl.handle.net/11368/3033100
Autor:
Jacob Househam, Timon Heide, George D. Cresswell, Inmaculada Spiteri, Chris Kimberley, Luis Zapata, Claire Lynn, Chela James, Maximilian Mossner, Javier Fernandez-Mateos, Alessandro Vinceti, Ann-Marie Baker, Calum Gabbutt, Alison Berner, Melissa Schmidt, Bingjie Chen, Eszter Lakatos, Vinaya Gunasri, Daniel Nichol, Helena Costa, Miriam Mitchinson, Daniele Ramazzotti, Benjamin Werner, Francesco Iorio, Marnix Jansen, Giulio Caravagna, Chris P. Barnes, Darryl Shibata, John Bridgewater, Manuel Rodriguez-Justo, Luca Magnani, Andrea Sottoriva, Trevor A. Graham
Genetic and epigenetic variation, together with transcriptional plasticity, contribute to intratumour heterogeneity1. The interplay of these biological processes and their respective contributions to tumour evolution remain unknown. Here we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9fb758339ef8ee25db6195aead51c0
https://hdl.handle.net/11368/3033099
https://hdl.handle.net/11368/3033099
Autor:
Salpie Nowinski, Kane Smith, Ailsa Hart, Morgan Moorghen, Ibrahim Al-Bakir, Ann-Marie Baker, Mehmet Yalchin, Kit Curtius, Trevor A. Graham, Chris Kimberley
Publikováno v:
Posters – highly commended.
Autor:
Luis Zapata, Melissa Schmidt, Maximilian Mossner, Marnix Jansen, Chris Kimberley, Miriam Mitchinson, Calum Gabbutt, Giulio Caravagna, Jacob Househam, Helena Costa, Alison May Berner, Inmaculada Spiteri, Bingjie Chen, Claire Lynn, George D. Cresswell, John Bridgewater, Manuel Rodriguez-Justo, Darryl Shibata, Timon Heide, Luca Magnani, Trevor A. Graham, Andrea Sottoriva, Daniel Nichol, Javier Fernández-Mateos, Ann-Marie Baker, Eszter Lakatos, Chela James
Cancer evolution is driven by natural selection acting upon phenotypic trait variation. However, the extent to which phenotypic variation within a tumour is a consequence of intra-tumour genetic heterogeneity remains undetermined. Here we show that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc61b0f47b8c0a0148b0e7543cf7a061
https://doi.org/10.1101/2021.07.18.451272
https://doi.org/10.1101/2021.07.18.451272
Autor:
Miriam Mitchinson, Giulio Caravagna, Luca Magnani, Chris Kimberley, Chris P. Barnes, John Bridgewater, Inmaculada Spiteri, Calum Gabbutt, Melissa Schmidt, Alison May Berner, Manuel Rodriguez-Justo, Marnix Jansen, Claire Lynn, Max Mossner, Chela James, Daniele Ramazzotti, Luis Zapata, Jacob Househam, Bingjie Chen, Alessandro Vinceti, Darryl Shibata, Helena Costa, George D. Cresswell, Ann-Marie Baker, Benjamin Werner, Timon Heide, Francesco Iorio, Eszter Lakatos, Javier Fernández-Mateos, Andrea Sottoriva, Trevor A. Graham, Daniel Nichol
Cancer genomic medicine relies on targeting driver genes. However, current catalogues of cancer drivers are mostly based on indirect measurements of mutation frequencies, positions or types, rather than their effect on clonal expansionsin vivo. Moreo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::086556328d77d35edfc59a809cb8cf92
https://doi.org/10.1101/2021.07.14.451265
https://doi.org/10.1101/2021.07.14.451265
Autor:
Timon Heide, Jacob Househam, George D Cresswell, Inmaculada Spiteri, Claire Lynn, Max Mossner, Chris Kimberley, Javier Fernandez-Mateos, Bingjie Chen, Luis Zapata, Chela James, Iros Barozzi, Ketevan Chkhaidze, Daniel Nichol, Alison Berner, Melissa Schmidt, Eszter Lakatos, Ann-Marie Baker, Helena Costa, Miriam Mitchinson, Marnix Jansen, Giulio Caravagna, Daniele Ramazzotti, Darryl Shibata, John Bridgewater, Manuel Rodriguez-Justo, Luca Magnani, Trevor A Graham, Andrea Sottoriva
Colorectal malignancies are a leading cause of cancer death. Despite large-scale genomic efforts, DNA mutations do not fully explain malignant evolution. Here we study the co-evolution of the genome and epigenome of colorectal tumours at single-clone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75ddc160c744d9e0dad51d06f2c2b475
https://doi.org/10.1101/2021.07.12.451121
https://doi.org/10.1101/2021.07.12.451121
Autor:
Chris P. Barnes, Riyaz S. Patel, Alexander R. A. Anderson, Martin I, Gabbutt C, Simon J. Leedham, Eszter Lakatos, Ryan O. Schenck, Susan K. Clark, Alison May Berner, Jacob Househam, A Latchford, Chris Kimberley, Trevor A. Graham, Mark Robertson-Tessi, Daniel J. Weisenberger, Darryl Shibata
Molecular clocks record cellular ancestry. However, currently used clocks ‘tick too slowly’ to measure the short-timescale dynamics of cellular renewal in adult tissues. Here we develop ‘rapidly oscillating DNA methylation clocks’ where ongoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bfe1b20f44b5bbc0900a1d9282a89b3
https://doi.org/10.1101/2021.03.15.435426
https://doi.org/10.1101/2021.03.15.435426