Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Chris J. Watson"'
Autor:
Claire Tonry, Katie Linden, Patrick Collier, Mark Ledwidge, Ken McDonald, Ben C. Collins, Chris J. Watson
Publikováno v:
Biomedicines, Vol 12, Iss 8, p 1712 (2024)
Hypertrophic cardiomyopathy (HCM) is a disease, which is difficult to diagnose at an early stage and for which there is a pressing need for more effective treatment options. The purpose of this study was to compare the molecular profile of HCM to tha
Externí odkaz:
https://doaj.org/article/d941efe8c8a94513aed6aa45230a16ab
Autor:
Adam Russell-Hallinan, Oisín Cappa, Lauren Kerrigan, Claire Tonry, Kevin Edgar, Nadezhda Glezeva, Mark Ledwidge, Kenneth McDonald, Patrick Collier, David A. Simpson, Chris J. Watson
Publikováno v:
Cells, Vol 13, Iss 9, p 752 (2024)
Dilated cardiomyopathy (DCM) is the most common cause of heart failure, with a complex aetiology involving multiple cell types. We aimed to detect cell-specific transcriptomic alterations in DCM through analysis that leveraged recent advancements in
Externí odkaz:
https://doaj.org/article/a7cf370415494e2eb326d5f7bf4fe291
Autor:
Shun Hay Pun, Karla M. O’Neill, Kevin S. Edgar, Eleanor K. Gill, Arya Moez, Hojjat Naderi-Meshkin, Sudhir B. Malla, Michelle B. Hookham, Mohammed Alsaggaf, Vinuthna Vani Madishetti, Bianca Botezatu, William King, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Derek P. Brazil, Reinhold J. Medina, Chris J. Watson, David J. Grieve
Publikováno v:
Cells, Vol 12, Iss 18, p 2220 (2023)
Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord blood-derived endothelial colony-forming cells (CB-ECFCs) hold clear therapeutic potential d
Externí odkaz:
https://doaj.org/article/c401b027209144cda01f2bdf818f87be
Autor:
Claire Sweeney, Rebabonye B. Pharithi, Brian Kerr, Cristin Ryan, Fiona Ryan, Líbhan Collins, Carmel Halley, Matt Barrett, Chris J. Watson, Kenneth McDonald, Mark Ledwidge
Publikováno v:
ESC Heart Failure, Vol 8, Iss 6, Pp 5081-5091 (2021)
Abstract Aims Guidelines support the role of B‐type natriuretic peptide (BNP) and amino‐terminal pro‐BNP (NT‐proBNP) for risk stratification of patients in programmes to prevent heart failure (HF). Although biologically formed in a 1:1 ratio,
Externí odkaz:
https://doaj.org/article/a9366d642f7e4ad6972574b41e9b72ed
Autor:
Aidonis Rammos, Aris Bechlioulis, Petros Kalogeras, Chris J. Watson, Pietro Salvo, Tommaso Lomonaco, Olga Kardakari, Evanthia E. Tripoliti, Yorgos Goletsis, Dimitris I. Fotiadis, Christos S. Katsouras, Lampros K. Michalis, Katerina K. Naka
Publikováno v:
Life, Vol 13, Iss 9, p 1818 (2023)
Background: Serum natriuretic peptides (NPs) have an established role in heart failure (HF) diagnosis. Saliva NT-proBNP that may be easily acquired has been studied little. Methods: Ninety-nine subjects were enrolled; thirty-six obese or hypertensive
Externí odkaz:
https://doaj.org/article/c28a4aae7c40425b99afaf3f4df84d12
Autor:
Claire Tonry, Ken McDonald, Mark Ledwidge, Belinda Hernandez, Nadezhda Glezeva, Cathy Rooney, Brian Morrissey, Stephen R. Pennington, John A. Baugh, Chris J. Watson
Publikováno v:
ESC Heart Failure, Vol 8, Iss 3, Pp 2248-2258 (2021)
Abstract Aims There is a critical need for better biomarkers so that heart failure can be diagnosed at an earlier stage and with greater accuracy. The purpose of this study was to design a robust mass spectrometry (MS)‐based assay for the simultane
Externí odkaz:
https://doaj.org/article/25f25217bca44988849d266b4594bfe3
Autor:
Chris J. Watson, Joe Gallagher, Mark Wilkinson, Adam Russell-Hallinan, Isaac Tea, Stephanie James, James O’Reilly, Eoin O’Connell, Shuaiwei Zhou, Mark Ledwidge, Ken McDonald
Publikováno v:
Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)
Abstract Background The purpose of this study was to investigate the utility of BNP, hsTroponin-I, interleukin-6, sST2, and galectin-3 in predicting the future development of new onset heart failure with preserved ejection fraction (HFpEF) in asympto
Externí odkaz:
https://doaj.org/article/f7c690cdc6cc491e88c2d8615ea1a7c3
Autor:
Andrzej S. Januszewski, Chris J. Watson, Vikki O’Neill, Kenneth McDonald, Mark Ledwidge, Tracy Robson, Alicia J. Jenkins, Anthony C. Keech, Lana McClements
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Abstract Type 2 diabetes (T2D) is associated with increased risk of cardiovascular disease (CVD). As disturbed angiogenesis and endothelial dysfunction are strongly implicated in T2D and CVD, we aimed to investigate the association between a novel an
Externí odkaz:
https://doaj.org/article/ec07d944ce5f4cbf96962708943b5d15
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Background: Pre-eclampsia is a serious consideration for women with type 1 diabetes mellitus (T1DM) planning pregnancy. Risk stratification strategies, such as biomarkers measured in the first trimester of pregnancy, could help identify high-risk wom
Externí odkaz:
https://doaj.org/article/7e6c53205a494ed4a60372727abf7019
Autor:
Michael Chhor, Hao Chen, Djurdja Jerotić, Milorad Tešić, Valentina N. Nikolić, Milan Pavlović, Rada M. Vučić, Benjamin Rayner, Chris J. Watson, Mark Ledwidge, Kenneth McDonald, Tracy Robson, Kristine C. McGrath, Lana McClements
Publikováno v:
Biomolecules, Vol 13, Iss 2, p 395 (2023)
Heart failure (HF) is the leading cause of hospitalisations worldwide, with only 35% of patients surviving the first 5 years after diagnosis. The pathogenesis of HF with preserved ejection fraction (HFpEF) is still unclear, impeding the implementatio
Externí odkaz:
https://doaj.org/article/bbab7a93b95e4f2399fd6db0dc49f34a