Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Chris J. Twelves"'
Autor:
Gerard M. Walls, Jamie B. Oughton, Anthony J. Chalmers, Sarah Brown, Fiona Collinson, Martin D. Forster, Kevin N. Franks, Alexandra Gilbert, Gerard G. Hanna, Nicola Hannaway, Stephen Harrow, Tom Haswell, Crispin T. Hiley, Samantha Hinsley, Matthew Krebs, Geraldine Murden, Rachel Phillip, Anderson J. Ryan, Ahmed Salem, David Sebag-Montefoire, Paul Shaw, Chris J. Twelves, Katrina Walker, Robin J. Young, Corinne Faivre-Finn, Alastair Greystoke
Publikováno v:
Clinical and Translational Radiation Oncology, Vol 25, Iss , Pp 61-66 (2020)
Lung cancer is the leading cause of cancer mortality worldwide and most patients are unsuitable for ‘gold standard’ treatment, which is concurrent chemoradiotherapy. CONCORDE is a platform study seeking to establish the toxicity profiles of multi
Externí odkaz:
https://doaj.org/article/18ea8996e30244118c8f0fb5dfce7ad3
Autor:
Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, Adel Samson
Supplementary Figure from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31a91d9095b10d23365f7a59df1819f1
https://doi.org/10.1158/2326-6066.22544210.v1
https://doi.org/10.1158/2326-6066.22544210.v1
Autor:
Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, Adel Samson
Supplementary Data from Neoadjuvant Intravenous Oncolytic Vaccinia Virus Therapy Promotes Anticancer Immunity in Patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7c77efbfb3b8e77a0ae08974c11a08
https://doi.org/10.1158/2326-6066.22544216.v1
https://doi.org/10.1158/2326-6066.22544216.v1
Autor:
Fiona Collinson, Alan A. Melcher, Alan Anthoney, Darren J. Newton, Christy Ralph, Fiona Errington-Mais, Hardev Pandha, Richard G. Vile, Kevin J. Harrington, Chris J. Twelves, John Bell, Rebecca Auer, Giles J. Toogood, K.R. Prasad, Monika Lusky, Nicolas Stojkowitz, Kaidre Bendjama, Victoria A. Jennings, Barbara da Silva, Michelle Johnpulle, Jennifer Kingston, Emma Tidswell, Adam Peckham-Cooper, Rajiv V. Dave, Bethany Kuszlewicz, Samantha Turnbull, Karen J. Scott, Jonathan Carmichael, Emma J. West, Adel Samson
Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally immunotherapeutic oncolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd6fa47fd5f357dfeeffbe9b9017d6b
https://doi.org/10.1158/2326-6066.c.6550577
https://doi.org/10.1158/2326-6066.c.6550577
Autor:
Chris J. Twelves, Alshad S. Lalani, Alvin Wong, Peter A. Harris, Chris R. Dunk, Egils Vjaters, Alan Anthoney, Chris Alcock, Neil Burnet, Roy Rampling, Roger M. Phillips, Philip H. Jones, Paul M. Loadman, Mark R. Albertella
Purpose: AQ4N is a novel bioreductive prodrug under clinical investigation. Preclinical evidence shows that AQ4N penetrates deeply within tumors and undergoes selective activation to form AQ4, a potent topoisomerase II inhibitor, in hypoxic regions o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::453fae2fae2fe778f3d3910b95e08d71
https://doi.org/10.1158/1078-0432.c.6516915.v1
https://doi.org/10.1158/1078-0432.c.6516915.v1
Autor:
Chris J. Twelves, Alshad S. Lalani, Alvin Wong, Peter A. Harris, Chris R. Dunk, Egils Vjaters, Alan Anthoney, Chris Alcock, Neil Burnet, Roy Rampling, Roger M. Phillips, Philip H. Jones, Paul M. Loadman, Mark R. Albertella
Supplementary Tables S1-S5 from Hypoxia-Selective Targeting by the Bioreductive Prodrug AQ4N in Patients with Solid Tumors: Results of a Phase I Study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3de084c3a0b5fd417852841501f36f6a
https://doi.org/10.1158/1078-0432.22439448
https://doi.org/10.1158/1078-0432.22439448
Autor:
Adel Samson, Emma J. West, Jonathan Carmichael, Karen J. Scott, Samantha Turnbull, Bethany Kuszlewicz, Rajiv V. Dave, Adam Peckham-Cooper, Emma Tidswell, Jennifer Kingston, Michelle Johnpulle, Barbara da Silva, Victoria A. Jennings, Kaidre Bendjama, Nicolas Stojkowitz, Monika Lusky, K.R. Prasad, Giles J. Toogood, Rebecca Auer, John Bell, Chris J. Twelves, Kevin J. Harrington, Richard G. Vile, Hardev Pandha, Fiona Errington-Mais, Christy Ralph, Darren J. Newton, Alan Anthoney, Alan A. Melcher, Fiona Collinson
Publikováno v:
Cancer Immunology Research. 10:745-756
Improving the chances of curing patients with cancer who have had surgery to remove metastatic sites of disease is a priority area for cancer research. Pexa-Vec (Pexastimogene Devacirepvec; JX-594, TG6006) is a principally immunotherapeutic oncolytic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::950f3f33403d7506d7775a2e7565c5f9
https://doi.org/10.1158/2326-6066.cir-21-0171
https://doi.org/10.1158/2326-6066.cir-21-0171
Autor:
Denis Larsimont, Daniel Rea, Alison F. Munro, Janet A. Dunn, Carlos Caldas, Frances P. O'Malley, Christopher C. McConkey, Angelo Di Leo, Christine Desmedt, David Cameron, Helena M. Earl, Lois E. Shepherd, Maj-Britt Jensen, Christopher J. Poole, Bent Ejlertsen, John M. S. Bartlett, Fatima Cardoso, Kathleen I. Pritchard, Chris J. Twelves
Publikováno v:
Journal of Clinical Oncology. 33:1680-1687
Purpose Evidence supporting the clinical utility of predictive biomarkers of anthracycline activity is weak, with a recent meta-analysis failing to provide strong evidence for either HER2 or TOP2A. Having previously shown that duplication of chromoso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9d62db83f632ff1535f2fb8057b6482
https://doi.org/10.1200/jco.2013.54.7869
https://doi.org/10.1200/jco.2013.54.7869
Autor:
Malcolm R. Clench, Cristina Russo, Paul M. Loadman, Patricia A. Cooper, Ramon Salazar, Maria Jove Casulleras, Steve D. Shnyder, Chris J Twelves, Amanda D. Race, Jade A. Spencer
Publikováno v:
Cancer Research. 78:4926-4926
Background: Eri & Cap are active as single agents in metastatic breast cancer, but the combination appears particularly active & well tolerated clinically. We explored the hypothesis that normalisation of tumor vasculature by Eri seen in preclinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48d4709045d23d4fd5e81be7ffe81d53
https://doi.org/10.1158/1538-7445.am2018-4926
https://doi.org/10.1158/1538-7445.am2018-4926
Autor:
Chris J Twelves, Michael Braun
Publikováno v:
Therapy. 6:239-248
Capecitabine is an oral pro-drug that is converted, via a three-step enzymatic pathway, into the cytotoxic drug 5-fluorouracil. 5-fluorouracil has an established role in the management of patients with colorectal cancer in the adjuvant and advanced d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31aa3237c2082864bc73e23ddce50097
https://doi.org/10.2217/14750708.6.2.239
https://doi.org/10.2217/14750708.6.2.239