Zobrazeno 1 - 10
of 193
pro vyhledávání: '"Chris J. Packard"'
Autor:
Marja-Riitta Taskinen, Elias Björnson, Niina Matikainen, Sanni Söderlund, Joel Rämö, Mari-Mia Ainola, Antti Hakkarainen, Carina Sihlbom, Annika Thorsell, Linda Andersson, Per-Olof Bergh, Marcus Henricsson, Stefano Romeo, Martin Adiels, Samuli Ripatti, Markku Laakso, Chris J. Packard, Jan Borén
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Background Apolipoprotein C-III (apoC-III) is a regulator of triglyceride (TG) metabolism, and due to its association with risk of cardiovascular disease, is an emergent target for pharmacological intervention. The impact of substantially lowering ap
Externí odkaz:
https://doaj.org/article/04b0164112e64cf5949fe5d13f341920
Autor:
Jean-Charles Fruchart, Raul D. Santos, Carlos Aguilar-Salinas, Masanori Aikawa, Khalid Al Rasadi, Pierre Amarenco, Philip J. Barter, Richard Ceska, Alberto Corsini, Jean-Pierre Després, Patrick Duriez, Robert H. Eckel, Marat V. Ezhov, Michel Farnier, Henry N. Ginsberg, Michel P. Hermans, Shun Ishibashi, Fredrik Karpe, Tatsuhiko Kodama, Wolfgang Koenig, Michel Krempf, Soo Lim, Alberto J. Lorenzatti, Ruth McPherson, Jesus Millan Nuñez-Cortes, Børge G. Nordestgaard, Hisao Ogawa, Chris J. Packard, Jorge Plutzky, Carlos I. Ponte-Negretti, Aruna Pradhan, Kausik K. Ray, Željko Reiner, Paul M. Ridker, Massimiliano Ruscica, Shaukat Sadikot, Hitoshi Shimano, Piyamitr Sritara, Jane K. Stock, Ta-Chen Su, Andrey V. Susekov, André Tartar, Marja-Riitta Taskinen, Alexander Tenenbaum, Lale S. Tokgözoğlu, Brian Tomlinson, Anne Tybjærg-Hansen, Paul Valensi, Michal Vrablík, Walter Wahli, Gerald F. Watts, Shizuya Yamashita, Koutaro Yokote, Alberto Zambon, Peter Libby
Publikováno v:
Cardiovascular Diabetology, Vol 18, Iss 1, Pp 1-20 (2019)
Abstract In the era of precision medicine, treatments that target specific modifiable characteristics of high-risk patients have the potential to lower further the residual risk of atherosclerotic cardiovascular events. Correction of atherogenic dysl
Externí odkaz:
https://doaj.org/article/6f4201f8fd5540cfabc2d78a10d3be4d
Autor:
Jan Borén, Martin Adiels, Elias Björnson, Niina Matikainen, Sanni Söderlund, Joel Rämö, Marcus Ståhlman, Pietari Ripatti, Samuli Ripatti, Aarno Palotie, Rosellina M. Mancina, Antti Hakkarainen, Stefano Romeo, Chris J. Packard, Marja-Riitta Taskinen
Publikováno v:
JCI Insight, Vol 5, Iss 24 (2020)
Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation. The transmembrane 6 superfamily member 2 (TM6SF2) E167K genetic variant associates with NAFLD and with reduced plasma triglyceride levels in humans. However, the
Externí odkaz:
https://doaj.org/article/0c247ff8398d40deb9bf1ec369f50d80
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Cardiovascular disease (CVD) is the leading cause of death globally. It is well-established based on evidence accrued during the last three decades that high plasma concentrations of cholesterol-rich atherogenic lipoproteins are causatively linked to
Externí odkaz:
https://doaj.org/article/668108ae01c949a7a374f4d9eb1580f9
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Elevations in plasma triglyceride are the result of overproduction and impaired clearance of triglyceride-rich lipoproteins—very low-density lipoproteins (VLDL) and chylomicrons. Hypertriglyceridemia is characterized by an accumulation in the circu
Externí odkaz:
https://doaj.org/article/4dd6d61a289d4b4a965634c23c05678e
Autor:
Rajeev Krishnadas, John McLean, G. David Batty, Harry Burns, Kevin A. Deans, Ian Ford, Alex McConnachie, Agnes McGinty, Jennifer S. McLean, Keith Millar, Naveed Sattar, Paul G. Shiels, Yoga N. Velupillai, Chris J. Packard, Jonathan Cavanagh
Publikováno v:
NeuroImage: Clinical, Vol 9, Iss C, p e1 (2015)
Externí odkaz:
https://doaj.org/article/3a2a26001c2f490a99381122f062d25c
Autor:
Hazel A. Ardern, G. Martin Benson, Keith E. Suckling, Muriel J. Caslake, James Shepherd, Chris J. Packard
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 12, Pp 2234-2243 (1999)
The St. Thomas' mixed hyperlipidemic (SMHL) rabbit (previously St. Thomas' Hospital rabbit) is a putative model of familial combined hyperlipidemia (FCH). When fed a low (0.08%) cholesterol diet, it exhibits elevations in both plasma cholesterol and
Externí odkaz:
https://doaj.org/article/82067a83eb6d4cc9adc6d138fc5a9a2d
Autor:
Clive R. Pullinger, Dairena Gaffney, Monica M. Gutierrez, Mary J. Malloy, Verne N. Schumaker, Chris J. Packard, John P. Kane
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 2, Pp 318-327 (1999)
Familial ligand-defective apolipoprotein B (apoB) is a group of disorders caused by mutations in the apoB gene. In this report the R3531C mutation is characterized further using a monoclonal antibody MB19/dynamic laser light scattering technique to m
Externí odkaz:
https://doaj.org/article/0c33587e40b84a90b52f268224d592a2
Autor:
M. John Chapman, Chris J. Packard
Publikováno v:
Journal of the American College of Cardiology. 81:1565-1568
Publikováno v:
Nature Reviews Cardiology. 19:577-592
Accumulating evidence points to the causal role of triglyceride-rich lipoproteins and their cholesterol-enriched remnants in atherogenesis. Genetic studies in particular have not only revealed a relationship between plasma triglyceride levels and the