Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chris J. Malajczuk"'
Publikováno v:
Journal of Structural Biology: X, Vol 5, Iss , Pp 100042- (2021)
Human serum high-density lipoproteins (HDLs) are a population of small, dense protein-lipid aggregates that are crucial for intravascular lipid trafficking and are protective against cardiovascular disease. The spheroidal HDL subfraction can be separ
Externí odkaz:
https://doaj.org/article/21305d6292d645ada4ded013c7e8ce5c
Publikováno v:
The journal of physical chemistry. B. 126(13)
The potentially damaging action of dimethyl sulfoxide (DMSO) on phospholipid bilayers remains a matter of controversy. We have conducted a series of long-scale molecular dynamics simulations of 1,2-dioleoyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c72ffc05eed8b30db99bf29705bc761a
https://pubmed.ncbi.nlm.nih.gov/35344357
https://pubmed.ncbi.nlm.nih.gov/35344357
Publikováno v:
The journal of physical chemistry. B. 126(1)
The mechanism by which cryosolvents such as alcohols modify and penetrate cell membranes as a function of their concentration and hydration state remains poorly understood. We conducted molecular dynamics simulations of 1,2-dioleoyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::234679ae76d3f32b1a59e45cb0db4d94
https://pubmed.ncbi.nlm.nih.gov/34967634
https://pubmed.ncbi.nlm.nih.gov/34967634
Publikováno v:
Langmuir. 35:15389-15400
Sugar-membrane interactions are believed to be responsible for cell preservation during desiccation and freezing, but the molecular mechanism by which they achieve this is still not well understood. The associated decrease of the main phase transitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cd2973ed8b6f8ae128456415a1b95dc
https://doi.org/10.1021/acs.langmuir.9b03086
https://doi.org/10.1021/acs.langmuir.9b03086
Autor:
Ralph N. Martins, Mark J. Howard, Tanya Solomon, Chris J. Malajczuk, Phillip Newsholme, Damien W. M. Arrigan, Ricardo L. Mancera, Prashant Bharadwaj
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1860:1639-1651
The beta amyloid protein (Aβ) plays a central role in Alzheimer's disease (AD) pathogenesis and its interaction with cell membranes in known to promote mutually disruptive structural perturbations that contribute to amyloid deposition and neurodegen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e40f943d3cb96f4ecfb81c5b9f5805e
https://doi.org/10.1016/j.bbamem.2018.03.015
https://doi.org/10.1016/j.bbamem.2018.03.015
Publikováno v:
Langmuir : the ACS journal of surfaces and colloids. 35(6)
Biophysical studies of model cell membranes at full and low hydration are usually carried out using scattering measurements on multi-bilayer systems. Molecular simulations of lipid bilayers aimed at reproducing those experimental conditions are usual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caffef02ffedea0d1ba5f72969048f92
https://pubmed.ncbi.nlm.nih.gov/30632763
https://pubmed.ncbi.nlm.nih.gov/30632763
Publikováno v:
Journal of Molecular Modeling. 24
Due to its protective properties of biological samples at low temperatures and under desiccation, dimethyl sulfoxide (DMSO) in aqueous solutions has been studied widely by many experimental approaches and molecular dynamics (MD) simulations. In the c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0680ad6a4425b831a4287f6f6ac93152
https://doi.org/10.1007/s00894-018-3720-x
https://doi.org/10.1007/s00894-018-3720-x
Publikováno v:
Journal of Integrative Bioinformatics
Journal of Integrative Bioinformatics, Vol 15, Iss 2, Pp 1616-23 (2018)
Journal of Integrative Bioinformatics, Vol 15, Iss 2, Pp 1616-23 (2018)
Molecular graphics systems are visualization tools which, upon integration into a 3D immersive environment, provide a unique virtual reality experience for research and teaching of biomolecular structure, function and interactions. We have developed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67db5f4f9efcc2de6ad8907b6ad0cca7
http://europepmc.org/articles/PMC6167041
http://europepmc.org/articles/PMC6167041
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828(9):2041-2055
Molecular dynamics (MD) simulations have been used to investigate the interactions of a variety of hydroxylated cryosolvents (glycerol, propylene glycol and ethylene glycol), methanol and dimethyl sulfoxide (DMSO) in aqueous solution with a 1,2-dipal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35afa001c3529a74e375d36ef3f4df7e
Publikováno v:
The journal of physical chemistry. B. 117(12)
Polyhydroxylated alcohols and DMSO are common cryosolvents that can damage cell membranes at sufficiently high concentrations. The interaction of representative plant cell membranes composed of mixed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)-β
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1ecf5824298a8fbe549f744b62d3ab
https://pubmed.ncbi.nlm.nih.gov/23445456
https://pubmed.ncbi.nlm.nih.gov/23445456